Cytomegalovirus disease in patients with hematopoietic stem cell transplantation, experience over 8 years

Díaz, Laura; Rosales, Joaquín; Rosso, Fernando; Rosales, María; Estacio, Mayra; Manzi, Eliana; Jaramillo, Francisco

doi:10.1016/j.htct.2018.10.004

Cited by 10 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the time between the transplantation and first detection of HCMV DNA was about 1 month in allogeneic transplant cases and about 10 days in autologous transplant cases. This indicates that due to immunosuppression, HCMV infection is more common in the first 3 months after transplantation, which is in accordance with previous reports [46].…”

Section: Discussionsupporting

confidence: 93%

Survey of HCMV in allogenic and autologous stem cell transplantation by real-time PCR in Kermanshah, west of Iran

Payandeh

Zamanian

Nomanpour

et al. 2021

Infect Agents Cancer

View full text Add to dashboard Cite

Introduction Human Cytomegalovirus (HCMV) is the most important viral pathogen in people undergoing bone marrow transplantation (BMT). HCMV detection in the early stages makes is possible to save the patients’ lives through immediate and timely treatment. The aim of this study was to investigate the status of HCMV using the real-time PCR method in BMT patients in Kermanshah, west of Iran. Methods HCMV monitoring was done in 120 patients who underwent BMT, 38 allogeneic cases and 82 autologous cases, using the ELISA serology test before transplantation. The participants were followed up 100 days after transplantation for HCMV detection in blood samples using real-time PCR. Preemptive therapy started with Ganciclovir and Foscarnet when the viral load was > 200 HCMV DNA copies/ml. Results Despite preemptive therapy, infection recurred in less than 1 month. HCMV recurred more frequently in patients undergoing allogenic transplation versus those receiving autologous transplantation. Recurrence was seen in 5 patients receiving allogenic transplantation. HCMV recurrence occurred in five patients with allogeneic transplantation. Twelve patients undergoing allogeneic or autologous transplantation (83%) and a virus load of > 1000 copies/ml showed HCMV-related symptoms. Three patients died, two due to HCMV-related pneumonia and the other one due to a fungal infection. Conclusion Real-time PCR may be a useful method for quantification and monitoring of HCMV recurrence and may be helpful in choosing more efficient HCMV preemptive treatment in BMT recipients.

show abstract

Section: Discussionsupporting

confidence: 93%

Survey of HCMV in allogenic and autologous stem cell transplantation by real-time PCR in Kermanshah, west of Iran

Payandeh

Zamanian

Nomanpour

et al. 2021

Infect Agents Cancer

View full text Add to dashboard Cite

show abstract

“…The seropositivity prevalence for CMV before transplantation in our study was 91% in donors and 92% in recipients, which agrees with that reported in adult patients undergoing HSCT in our institution 44 and other population contexts in our country. [45][46][47] This high prevalence could be related to the sociodemographic characteristics, high rates of poverty and overcrowding within the population.…”

Section: Discussionsupporting

confidence: 91%

Risk factors and incidence of cytomegalovirus viremia and disease in pediatric patients with allogeneic hematopoietic stem cell transplantation: An 8‐year single‐center experience in Latin America

Aristizábal

Pérez

Niño

et al. 2022

Pediatric Transplantation

View full text Add to dashboard Cite

Background: Cytomegalovirus infection represents a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. This study aimed to evaluate the incidence of viremia and disease due to cytomegalovirus and the risk factors in pediatric patients with hematopoietic stem cell transplantation in our institution. Methods: This was a retrospective cohort of patients under 19 years of age who underwent allogeneic hematopoietic stem cell transplantation due to any indication between 2012 and 2019. The analysis included the diagnosis of cytomegalovirus viremia or disease during post-transplant follow-up, evaluation of risk factors, and outcomes.The statistical analysis included univariate and multivariate analyses, and the cumulative incidence of cytomegalovirus viremia was determined by the Kaplan-Meier method using STATA 14 statistical software.Results: A total of 182 transplants were included. At 100 days, the cumulative incidence of cytomegalovirus viremia was 70.5%, and that of cytomegalovirus disease was 4.7%. Overall survival at 2 years was 74%, and event-free survival was 64%. The remaining demographic characteristics were not predictors of infection. There was no association between viremia and relapse or survival of the patients. Higher mortality was noted in cytomegalovirus disease.Conclusions: During the study period, the incidence of cytomegalovirus disease was similar to that of other pediatric reports, but the incidence of viremia was higher. Preemptive therapy has diminished disease rates and death due to infection. Viral load cutoff points should be standardized to guide treatment and avoid myelotoxicity.

show abstract

“…In the HAART era, CMV retinitis was significantly reduced [ 15 ], but it is still the most common form of CMV disease in AIDS patients [ 6 ]. However, it is not the most common form of CMV disease in HSCT patients [ 16 ], and the incidence is reported as 0.17–2.3% [ 3 , 17 – 20 ]. Second, the greatest risk factor for CMV infection after solid organ transplantation is a CMV-seropositive donor to a CMV-seronegative recipient.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors of cytomegalovirus retinitis after hematopoietic stem cell transplantation

et al. 2020

View full text Add to dashboard Cite

To identify the visual prognostic factors in patients with cytomegalovirus (CMV) retinitis after hematopoietic stem cell transplantation (HSCT). Methods This retrospective cohort study included 4241 patients who underwent HSCT from April 1, 2010 to March 31, 2019 at Seoul St. Mary's Hospital. Of them, 1063 patients presented CMV viremia, and 67 patients (93 eyes) were diagnosed with CMV retinitis. We enrolled 66 patients (91 eyes). The main outcomes included the initial best-corrected visual acuity (BCVA), BCVA at the diagnosis of retinitis and last visit, involved retinal zone, peak CMV DNA levels in the peripheral blood and aqueous humor, time between HSCT and the diagnosis of retinitis, time between the diagnosis of viremia and retinitis, complications, recurrence, survival, and so on. Results The mean BCVA (logarithm of the minimum angle of resolution) values before HSCT, at the time of retinitis diagnosis, and at the last visit were 0.041 ± 0.076, 0.262 ± 0.529, and 0.309 ± 0.547, respectively. Multiple regression analysis revealed that the involved zone (P = 0.001), time between HSCT and retinitis diagnosis (P = 0.019), and survival status (P = 0.001) were associated with the final visual acuity. Conclusions The final visual prognosis was worse in patients with greater invasion of the central retinal zone, those with a longer interval between HSCT and the diagnosis of retinitis, and those who died. Prompt diagnosis of CMV retinitis through periodic fundus examinations of

show abstract

Cytomegalovirus disease in patients with hematopoietic stem cell transplantation, experience over 8 years

Cited by 10 publications

References 14 publications

Survey of HCMV in allogenic and autologous stem cell transplantation by real-time PCR in Kermanshah, west of Iran

Survey of HCMV in allogenic and autologous stem cell transplantation by real-time PCR in Kermanshah, west of Iran

Risk factors and incidence of cytomegalovirus viremia and disease in pediatric patients with allogeneic hematopoietic stem cell transplantation: An 8‐year single‐center experience in Latin America

Prognostic factors of cytomegalovirus retinitis after hematopoietic stem cell transplantation

Contact Info

Product

Resources

About