Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis

Pylväs, Marjo; Puistola, Ulla; Kauppila, Saila; Soini, Ylermi; Karihtala, Peeter

doi:10.1016/j.ejca.2010.02.006

Cited by 47 publications

(30 citation statements)

References 16 publications

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“…It is known that severe oxidative stress does not only cause damage and mutation in tumour suppressor genes, but also plays a significant role in carcinogenesis [7,8]. In addition, there are studies suggesting that antioxidant levels such as vitamin E, vitamin C, superoxide dismutase and catalase are decreased in the plasma of patients with ovarian cancer, whereas these patients also display increased lipid peroxidation and oxidative stress levels [7,21,22]. In our study, in which we investigated whether there was a difference in oxidative stress among the EOC, the BOT and the control group, we found that the oxidative stress markers TOS and OSI were significantly higher, whereas TAS levels were significantly lower in patients with EOC.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Apoptotic Activity Dysregulation and Oxidative Stress in the Development of Epithelial Ovarian Cancer: A Case-Controlled Descriptive Analysis

Incebiyik

Camuzcuoğlu²,

Vural³

et al. 2015

Gynecol Obstet Invest

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Aim: In the present study, we aimed to assess whether oxidative stress and apoptotic activity play a role in the development of epithelial ovarian cancer (EOC). Methods: The study group included patients with EOC (n = 26) and benign ovarian tumour (BOT) (n = 25), while 30 healthy women were employed as a control group. Venous blood samples were drawn to evaluate oxidative stress parameters and serum M30/M65 antigen levels before surgery. In addition, blood samples were taken for the second time on postoperative day 8 to analyse whether the postoperative tumour load was decreased. Results: When the groups were assessed regarding oxidative stress, the highest values were detected in patients with EOC. Serum M30/M65 levels were found to be higher in patients with EOC when compared to the other groups (p < 0.001). A significant decrease was determined in the M30/M65 levels of serum samples taken on postoperative day 8 from the patients in the EOC and BOT groups (p < 0.001). Conclusion: Our results suggest that dysregulation of apoptotic activity could be effective in the development of ovarian tumoural tissue, whereas oxidative stress could be effective in malignant transformation.

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Section: Discussionmentioning

confidence: 99%

“…There is strong evidence suggesting that ROS are an important factor in carcinogenesis [21,22]. It is known that severe oxidative stress does not only cause damage and mutation in tumour suppressor genes, but also plays a significant role in carcinogenesis [7,8].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Apoptotic Activity Dysregulation and Oxidative Stress in the Development of Epithelial Ovarian Cancer: A Case-Controlled Descriptive Analysis

Incebiyik

Camuzcuoğlu²,

Vural³

et al. 2015

Gynecol Obstet Invest

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“…Patients with cancer are exposed to considerable oxidative stress induced by both disease and the cancer treatment protocol [73,74,[98][99][100]. Monitoring of the changes in levels of oxidative stress using easier and fully automated methodical approach could bring the immediate modification of treatment protocol to these patients (personalized medicine).…”

Section: Detection Of 8-ohdg In Patient With Prostate Cancermentioning

confidence: 99%

“…However, there were observed some significant differences in the determined concentrations of 8-OHdG depending on a type of a sample type and used antibody [69]. Immunohistochemistry using antibodies to localize the antigen of interest in a tissue has been successfully utilized also for 8-OHdG determination in numerous types of tissues as gallbladder [70], liver [71], renal [61], hippocampus [72], breast [73], ovarian [74] and/or melanoma tissues [75]. In addition, immunoaffinity chromatography has been also tested for isolation of 8-OHdG with various types of subsequent detection [62,76].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic tool based on the antibody‐modified paramagnetic particles for detection of 8‐hydroxy‐2′‐deoxyguanosine in urine of prostate cancer patients

et al. 2011

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Guanosine derivatives are important for diagnosis of oxidative DNA damage including 8-hydroxy-2'-deoxyguanosine (8-OHdG) as one of the most abundant products of DNA oxidation. This compound is commonly determined in urine, which makes 8-OHdG a good non-invasive marker of oxidation stress. In this study, we optimized and tested the isolation of 8-OHdG from biological matrix by using paramagnetic particles with an antibody-modified surface. 8-OHdG was determined using 1-naphthol generated by alkaline phosphatase conjugated with the secondary antibody. 1-Naphthol was determined by stopped flow injection analysis (SFIA) with electrochemical detector using a glassy carbon working electrode and by stationary electrochemical detection using linear sweep voltammetry. A special modular electrochemical SFIA system which needs only 10 μL of sample including working buffer for one analysis was completely designed and successfully verified. The recoveries in different matrices and analyte concentration were estimated. Detection limit (3 S/N) was estimated as 5 pg/mL of 8-OHdG. This method promises to be very easily modified to microfluidic systems as "lab on valve". The optimized method had sufficient selectivity and thus could be used for determination of 8-OHDG in human urine and therefore for estimation of oxidative DNA damage as a result of oxidation stress in prostate cancer patients.

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“…Oxidative stress is suggested to occur already in both benign and borderline ovarian tumors. Antioxidant enzymes were profoundly induced in the latter, indicating a possible cancer preventive role [6]. Furthermore, OC reportedly has increased levels of oxidative stress, and inhibition of ROS might induce apoptosis, indicating a potential target for cancer therapy [7].…”

Section: Introductionmentioning

confidence: 99%

MGST1 expression in serous ovarian carcinoma differs at various anatomic sites, but is unrelated to chemoresistance or survival

Hetland¹,

Nymoen²,

Emilsen³

et al. 2012

Gynecologic Oncology

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Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis

Cited by 47 publications

References 16 publications

Assessment of Apoptotic Activity Dysregulation and Oxidative Stress in the Development of Epithelial Ovarian Cancer: A Case-Controlled Descriptive Analysis

Assessment of Apoptotic Activity Dysregulation and Oxidative Stress in the Development of Epithelial Ovarian Cancer: A Case-Controlled Descriptive Analysis

Microfluidic tool based on the antibody‐modified paramagnetic particles for detection of 8‐hydroxy‐2′‐deoxyguanosine in urine of prostate cancer patients

MGST1 expression in serous ovarian carcinoma differs at various anatomic sites, but is unrelated to chemoresistance or survival

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