Higher visceral adiposity index is associated with increased likelihood of abdominal aortic calcification

Zheng, Qin; Jiang, Luojia; Sun, Jiantong; Geng, Jiwen; Chen, Shanshan; Yang, Qinbo; Su, Baihai; Liao, Ri-Qiang

doi:10.1016/j.clinsp.2022.100114

Cited by 13 publications

(4 citation statements)

References 38 publications

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“…Over the observation period, both groups demonstrated a similar progression without significant differences, however, with considerable inter individual differences. It is also interesting that in contrast to earlier studies 4 , 34 in the FrOST cohort AAC volume was not correlated with MetSyn or with obesity and there was no correlation between AAC and VAT volume although AAC volume was similar to volumes of 1950 ± 2300 mm³ reported in by Fuji et al 35 in subjects with comparable age (but a different gender distribution).…”

Section: Discussioncontrasting

confidence: 63%

Effects of High-Intensity Resistance Training on Visceral Adipose Tissue and Abdominal Aortic Calcifications in Older Men with Osteosarcopenia – Results from the FrOST Study

Knauer¹,

Chaudry²,

Uder³

et al. 2023

CIA

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Purpose To evaluate the effect of a high-intensity resistance training (HIT-RT) on visceral adipose tissue (VAT) and abdominal aortic calcifications (AAC). Patients and Methods We conducted a post hoc analysis of the Franconian Osteopenia and Sarcopenia Trial (FrOST). 43 community-dwelling men with osteosarcopenia aged 72 years and older were randomly allocated to a supervised high-intensity resistance training (HIT-RT) twice weekly for 18 months (EG; n=21) and a non-training control group (CG; n=22). Non-contrast enhanced 2-point Dixon MRI scans covering mid L2 to mid L3 were acquired to measure VAT volume inside the abdominal cavity. Volume of AAC and hard plaques in renal arteries, truncus celiacus and superior mesenteric artery was measured by computed tomography (CT) scans covering mid T12 to mid L3. Intention-to-treat analysis with imputation for missing data was used to determine longitudinal changes in VAT and AAC volume. Correlations were used to determine associations between VAT and AAC. Results Significant reduction of VAT volume in the EG (−7.7%; p<0.001) combined with no change in the CG (−1.3%; p=0.46) resulted in a significant 6.4% between group effect (p=0.022). We observed a significant increase of AAC volume in EG (+10.3%; p<0.001) and CG (12.0%; p<0.001). AAC differences between groups were not significant (p=0.57). In vascular outlets increases in volume of the hard plaques were observed in both groups, however, not all of them were significant. There was no significant correlation between changes in VAT and AAC volumes. Conclusion The study confirmed a positive impact of HIT-RT on the metabolic and cardiovascular risk profile with respect to reduction of VAT volume. No positive exercise effect on AAC was observed. However, there was a further progression of AAC volume independent of group affiliation. Whether different exercise regimen may show a positive effect on AAC remains subject to further studies.

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Section: Discussioncontrasting

confidence: 63%

Effects of High-Intensity Resistance Training on Visceral Adipose Tissue and Abdominal Aortic Calcifications in Older Men with Osteosarcopenia – Results from the FrOST Study

Knauer¹,

Chaudry²,

Uder³

et al. 2023

CIA

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“…An affirmative answer was identified as a current fracture or fracture history at the specific site [ 34 , 35 ]. Covariates included demographic variables [age, sex, education levels, income-to-poverty ratio (PIR), and race]; examination variables [bone mineral density (BMD), waist circumference, and BMI]; laboratory variables [LDL-C (low-density lipoprotein cholesterol), total 25 (OH) D (25-hydroxy vitamin D), total calcium, and triglycerides]; dietary variables [dietary inflammatory index (calculated from 45 nutrient intakes)]; questionnaire variables [smoking status (Never/Ever/Current) [ 36 ], diabetes (Yes/No), use of hormone therapy (Yes/No)]. Comprehensive guidance regarding the collection methods of variables can be accessed from the NHANES Survey Methods ( https://wwwn.cdc.gov/nchs/nhanes ).…”

Section: Methodsmentioning

confidence: 99%

Associations between weight-adjusted waist index and fractures: a population-based study

et al. 2023

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Introduction The weight-adjusted waist circumference index (WWI) is a novel obesity evaluation indicator that appears to be superior to body mass index (BMI) and waist circumference (WC) in evaluating muscle and fat mass. The purpose of this study was to investigate the association between WWI and fractures among adults. Methods In this cross-sectional study, multivariate logistic regression and smoothed curve fitting were used to investigate linear and nonlinear associations between WWI and fractures, based on data from 28,679 adult participants in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Results After adjusting for all covariates, the prevalence of hip/wrist/spine fractures among all participants was 1.09%, 8.87%, and 1.97%, respectively. A 1-unit increase in WWI was associated with a 5% increase in the odds of hip fractures [1.05 (1.01, 1.10)], and a 9% increase in the odds of spine fractures [1.09 (1.06, 1.13)], but not with the prevalence of wrist fractures [0.97 (0.94, 1.06)]. Conclusions Higher WWI was associated with an increased prevalence of hip fracture and spine fracture, but not wrist fracture.

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“…Based on reviews of the literatures, potential covariates that may confound the association between WWI and AAC were summarized in our multivariable-adjusted models 30 , 33 , 37 , 38 . The covariates in present study included demographic covariates and health condition covariates.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, they also observed a correlation between visceral compartment size and serum osteoprotegerin levels, indicating a potential mechanism of visceral adiposity and AAC 29 . Additionally, visceral adiposity accumulation evaluated by the visceral adiposity index (VAI) was reported to be associated with an increased likelihood of AAC as well 30 . Fox et al 31 investigated the relation of subcutaneous and visceral adipose tissue to coronary and abdominal aortic calcium based on the Framingham Heart Study, they found BMI, WC and visceral adipose tissue were associated with AAC in the age and gender-adjusted models, but it could be attenuated by cardiovascular disease risk factors.…”

Section: Introductionmentioning

confidence: 99%

The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged ≥ 40 years: results from NHANES 2013–2014

Zheng

et al. 2022

Sci Rep

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The negative effects of obesity on the cardiovascular health have drawn much attention. Weight-adjusted-waist index (WWI) has been proved to reflect weight-independent centripetal obesity. However, the association between WWI and abdominal aortic calcification (AAC) has not been reported before. Using data from National Health and Nutrition Examination Survey 2013–2014, we aimed to determine the relationship of WWI and AAC in adults aged ≥ 40 years. WWI was determined by dividing waist circumference by the square root of weight. AAC was measured by dual-energy X-ray absorptiometry and quantified by Kauppila scores. Severe AAC (SAAC) was defined as an AAC score > 6. We utilized weighed multivariable logistic regression and generalized additive model to explore the independent association between WWI and AAC. Threshold effects were further calculated by two-piecewise linear regression model. 3082 participants were enrolled in our analysis, of which 48.2% were male. WWI was positively associated with AAC scores (β = 0.34, 95% CI 0.05–0.63) and exhibited a nonlinear relationship with SAAC. On the left of the breakpoint (WWI = 11.11), WWI and SAAC were positively associated (OR = 2.86, 95% CI 1.40–5.84), while no such relationship was found on the right (OR = 1.07, 95% CI 0.77–1.48). Our findings indicated that WWI may serve as a simple biomarker of AAC in US adults aged ≥ 40 years.

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Higher visceral adiposity index is associated with increased likelihood of abdominal aortic calcification

Cited by 13 publications

References 38 publications

Effects of High-Intensity Resistance Training on Visceral Adipose Tissue and Abdominal Aortic Calcifications in Older Men with Osteosarcopenia – Results from the FrOST Study

Effects of High-Intensity Resistance Training on Visceral Adipose Tissue and Abdominal Aortic Calcifications in Older Men with Osteosarcopenia – Results from the FrOST Study

Associations between weight-adjusted waist index and fractures: a population-based study

The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged ≥ 40 years: results from NHANES 2013–2014

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