Applications of carbon nanotubes in drug delivery

Bianco, Alberto; Kostarelos, Kostas; Prato, Maurizio

doi:10.1016/j.cbpa.2005.10.005

Cited by 1,710 publications

(982 citation statements)

References 44 publications

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“…Carbon nanotubes are carbon cylinders composed of benzene rings. They have been used to mediate drug delivery into cells [15] [16]. These recent reports are consistent with our own results.…”

Section: Discussionsupporting

confidence: 92%

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells

Tsukahara

Haniu

2011

Mol Cell Biochem

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Carbon nanotubes, a promising nanomaterial with unique characteristics, have applications in a variety of fields. The cytotoxic effects of carbon nanotubes are partially due to the induction of oxidative stress; however, the detailed mechanisms of nanotube cytotoxicity and their interaction with cells remain unclear. In the present study, we focus on the acute toxicity of vapor-grown carbon fiber, HTT2800, which is one of the most highly purified multi-wall carbon nanotube (MWCNT) by high-temperature thermal treatment. We exposed human bronchial epithelial cells (BEAS-2B) to HTT2800 and measured the cellular uptake, mitochondrial function, cellular LDH release, apoptotic signaling, reactive oxygen species (ROS) generation and pro-inflammatory cytokine release. The HTT2800-exposed cells showed cellular uptake of the carbon nanotube, increased cell death, enhanced DNA damage and induced cytokine release. However, the exposed cells showed no obvious intracellular ROS generation. These cellular and molecular findings suggest that HTT2800 could cause a potentially adverse inflammatory response in BEAS-2B cells.

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Section: Discussionsupporting

confidence: 92%

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells

Tsukahara

Haniu

2011

Mol Cell Biochem

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“…This is further amplified by an assortment of covalent and noncovalent functionalization strategies to link a variety of biological entities onto CNTs. [23,[37][38][39][40] The properties described above, along with excellent potential for device miniaturization, can allow CNTs to be key components of universal sensor platforms, where their unique optical and electronic properties are coupled with biorecognition and enzyme catalysis to enhance functionality.…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanotubes for Electronic and Electrochemical Detection of Biomolecules

2007

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The unique electronic and optical properties of carbon nanotubes, in conjunction with their size and mechanically robust nature, make these nanomaterials crucial to the development of next-generation biosensing platforms. In this Review, we present recent innovations in carbon nanotube-assisted biosensing technologies, such as DNA-hybridization, protein-binding, antibody-antigen and aptamers. Following a brief introduction on the diameter-and chirality-derived electronic characteristics of single-walled carbon nanotubes, the discussion is focused on the two major schemes for electronic biodetection, namely biotransistor-and electrochemistry-based sensors. Key fabrication methodologies are contrasted in light of device operation and performance, along with strategies for amplifying the signal while minimizing nonspecific binding. This Review is concluded with a perspective on future optimization based on array integration as well as exercising a better control in nanotube structure and biomolecular integration.

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“…Carbon nanotubes (CNTs), single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), have continued to attract intense research interests as ideal nanomaterials for the development of nanoelectronic devices [1], [2] and [3], drug delivery [4], [5] and openUP (July 2007) [6], and high-performance electrochemical sensors [7], [8], [9], [10] and [11]. These interests are based on the unique properties of CNTs such as high electrical conductivity, high surface area, significant mechanical strength and good chemical stability.…”

Section: Introductionmentioning

confidence: 99%