Peroxiredoxins, a novel target in cancer radiotherapy

Zhang, Bo; Wang, Yan; Su, Yongping

doi:10.1016/j.canlet.2009.04.043

Cited by 108 publications

(73 citation statements)

References 70 publications

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“…In addition, PRDX1 crystallized as toroid‐shaped complexes consisting of a pentameric arrangement of dimers [an (a 2 ) 5 decamer], consistent with observations that PRDX1 dimers can form discrete higher‐order oligomers 8. Compared with other antioxidant enzymes, PRDX1 employs a particular mechanism to detoxify peroxide with reducing equivalents provided through the thioredoxin (Trx) system but not from glutaredoxin 19.…”

Section: Structure Functions Of Prdx1 and Its Role In Ros‐dependent supporting

confidence: 72%

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Ding

Fan

2016

J Cellular Molecular Medi

151

116

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Peroxiredoxins (PRDXs), a ubiquitous family of redox‐regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over‐oxidized on its catalytically active cysteine induced by a variety of stimuli in vitro and in vivo. In nucleus, oligomeric PRDX1 directly associates with p53 or transcription factors such as c‐Myc, NF‐κB and AR, and thus affects their bioactivities upon gene regulation, which in turn induces or suppresses cell death. Additionally, PRDX1 in cytoplasm has anti‐apoptotic potential through direct or indirect interactions with several ROS‐dependent (redox regulation) effectors, including ASK1, p66Shc, GSTpi/JNK and c‐Abl kinase. PRDX1 is proven to be a versatile molecule regulating cell growth, differentiation and apoptosis. Recent studies have found that PRDX1 and/or PRDX1‐regulated ROS‐dependent signalling pathways play an important role in the progression and metastasis of human tumours, particularly in breast, oesophageal and lung cancers. In this paper, we review the structure, effector functions of PRDX1, its role in cancer and the pivotal role of ROS in anticancer treatment.

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Section: Structure Functions Of Prdx1 and Its Role In Ros‐dependent supporting

confidence: 72%

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Ding

Fan

2016

J Cellular Molecular Medi

151

116

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“…Literature data report an over-expression of PRDXs in several human cancers (mesothelioma, bladder, breast, and brain cancers) during tumorigenesis [Kinnula et al, 2002;Chang et al, 2007;Zhang et al, 2009], tumor recurrence or progression [Quan et al, 2006], and cancer therapies [An and Seong, 2006;Pak et al, 2011].…”

Section: Discussionmentioning

confidence: 99%

Molecular basis underlying the biological effects elicited by extremely low-frequency magnetic field (ELF-MF) on neuroblastoma cells

et al. 2011

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Extremely low-frequency magnetic fields (ELF-MFs) may affect human health because of the possible associations with leukemia but also with cancer, cardiovascular, and neurological disorders. In the present work, human SH-SY5Y neuroblastoma cells were exposed to a 50 Hz, 1 mT sinusoidal ELF-MF at three different times, that is, 5 days (T5), 10 days (T10), and 15 days (T15) and then the effects of ELF-MF on proteome expression and biological behavior were investigated. Through comparative analysis between treated and control samples, we analyzed the proteome changes induced by ELF-MF exposure. Nine new proteins resolved in sample after a 15-day treatment were involved in a cellular defense mechanism and/or in cellular organization and proliferation such as peroxiredoxin isoenzymes (2, 3, and 6), 3-mercaptopyruvate sulfurtransferase, actin cytoplasmatic 2, t-complex protein subunit beta, ropporin-1A, and profilin-2 and spindlin-1. Our results indicated that ELF-MFs exposure altered the proliferative status and other important cell biology-related parameters, such as cell growth pattern, and cytoskeletal organization. These findings support our hypothesis that ELF radiation could trigger a shift toward a more invasive phenotype.

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“…It is a member of the Prdxs family of antioxidant proteins which is known to be overexpressed in several different carcinomas [18,19]. Many studies indicated that aberrant expression of Prdxs was found in various kinds of cancers.…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Tumor Markers in Sudanese Breast Cancer Patients Using a Proteomic Approach

Elamin¹,

Franz²,

Ibrahim³

2017

J Cancer Sci Ther

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Breast cancer (BC) is considered as a major health problem in Sudan, being the most frequent hospital treated malignancy and the commonest cancer affecting Sudanese females (34%). Proteomics provides tools that investigate the precise molecular defect(s) in breast cancer tissue. Moreover, it plays a growingly important role in tumor markers discovery. In this study, a proteomic assay (2D-PAGE) was used to investigate the protein profiles of a panel of 12 Sudanese breast malignant tissues and 12 matched controls. Protein spots of interest were excised manually, and in-gel digested using trypsin. Proteins were identified using mass spectrometry (MALDI-TOF). Mascot program was used to search protein databases for matching peptides from known proteins. The overall profile was relatively similar, the preliminary results identified three proteins to be differentially expressed, suggesting that they may perform a role in breast neoplasia. Although the number of samples investigated in this study is comparatively small, to allow authoritative conclusions, the study provided three proteins that might be potential tumor markers in Sudanese breast cancer patients requiring further investigations and validation.

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Peroxiredoxins, a novel target in cancer radiotherapy

Cited by 108 publications

References 70 publications

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Molecular basis underlying the biological effects elicited by extremely low-frequency magnetic field (ELF-MF) on neuroblastoma cells

Identification of Potential Tumor Markers in Sudanese Breast Cancer Patients Using a Proteomic Approach

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