Cytotoxic effects of Euterpe oleraceae fruit oil (açaí) in rat liver and thyroid tissues

Marques, Eduardo de Souza; Froder, Juliano Gabriel; Oliveira, Patrícia Rosa de; Perazzo, Fábio Ferreira; Rosa, Paulo; Gaivão, Isabel; Mathias, Maria Izabel Camargo; Maistro, Edson Luis

doi:10.1016/j.bjp.2018.12.001

Cited by 15 publications

(6 citation statements)

References 21 publications

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“…As depicted in Figure 2 A, our results showed that AHE did not exert cytotoxic effects at lower doses, but reduced almost 50% of mitochondrial activity at the highest concentration tested (75 mg/L), affecting cellular viability, in comparison to control group ( p = 0.0026). In accordance, it has been recently demonstrated that açaí oil induces hepatic and thyroid tissue toxicity in male Wistar rats, after the intake of oil doses higher than 100 mg/kg for 14 days [ 32 ]. In comparison, no genotoxic effects were reported for the same doses in leukocytes, liver, bone marrow and testicular rat cells [ 33 ].…”

Section: Resultsmentioning

confidence: 77%

“…In comparison, no genotoxic effects were reported for the same doses in leukocytes, liver, bone marrow and testicular rat cells [ 33 ]. The toxic effects registered by histological and histochemical analysis were attributed to palmitic and oleic acids, major constituents of açaí oil, together with vanillic, g-linolenic, linoleic, cinnamic, caffeic, protocatechuic, ferulic, syringic acids, and flavonoids quercetin and kaempferol rutinoside [ 32 , 33 ]. For this reason, the further evaluation of the bioactive properties of AHE was assessed using non-toxic concentrations, in order to consider its pharmacological potential, since some of the compounds reported in fruit oil were also identified in AHE (e.g., protocatechuic acid and quercetin).…”

Section: Resultsmentioning

confidence: 99%

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Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement

et al. 2021

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The Euterpe oleracea fruit (açaí) is a promising source of polyphenols with health-promoting properties. To our knowledge, few studies have focused on the influence of açaí phytochemicals on angiogenesis, with a significant impact on cancer. This study aimed at investigating the phytochemical profile of a purple açaí hydroethanolic extract (AHE) obtained from a commercial dietary powder supplement by high-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry, and evaluate its in vitro effects on distinct angiogenic steps during vessel growth and on oxidative markers in human microvascular endothelial cells (HMEC-1). The phenolic profile of AHE revealed the presence of significant levels of anthocyanins, mainly cyanidin-3-O-rutinoside, and other flavonoids with promising health effects. The in vitro studies demonstrated that AHE exerts antiangiogenic activity with no cytotoxic effect. The AHE was able to decrease HMEC-1 migration and invasion potential, as well as to inhibit the formation of capillary-like structures. Additionally, AHE increased antioxidant defenses by upregulating superoxide dismutase and catalase enzymatic activities, accompanied by a reduction in the production of reactive oxygen species. These data bring new insights into the potential application of angiogenic inhibitors present in AHE on the development of novel therapeutic approaches for angiogenesis-dependent diseases.

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Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement

et al. 2021

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“…The ACP oil showed higher activity (2.1-fold) as an inhibitor against the proliferation of HT-29 human colon adenocarcinoma cells compared to the pulp extract obtained with ethyl acetate [182]. The cytotoxicity of ACP oil in rat liver and thyroid tissues [183] and its genotoxicity in mammalian cells in vivo were evaluated [184]. The results indicated that ACP oil did not present genotoxic effects in the animals' leukocytes, liver, bone marrow, and testicular cells.…”

Section: Bioactive Compoundsmentioning

confidence: 96%

Emerging Lipids from Arecaceae Palm Fruits in Brazil

2022

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Arecaceae palm tree fruits (APTFs) with pulp or kernel rich in oil are widely distributed in six Brazilian biomes. APTFs represent a great potential for the sustainable exploitation of products with high added value, but few literature studies have reported their properties and industrial applications. The lack of information leads to underutilization, low consumption, commercialization, and processing of these fruit species. This review presents and discusses the occurrence of 13 APTFs and the composition, physicochemical properties, bioactive compounds, and potential applications of their 25 oils and fats. The reported studies showed that the species present different lipid profiles. Multivariate analysis based on principal component analysis (PCA) and hierarchical cluster analysis (HCA) indicated a correlation between the composition of pulp and kernel oils. Myristic, caprylic, capric, and lauric acids are the main saturated fatty acids, while oleic acid is the main unsaturated. Carotenoids and phenolic compounds are the main bioactive compounds in APTFs, contributing to their high oxidative stability. The APTFs oils have a potential for use as foods and ingredients in the cosmetic, pharmaceutical, and biofuel industries. However, more studies are still necessary to better understand and exploit these species.

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“…However, Marques et al [ 186 ] used rat models to demonstrate that the oral administration of açaí oil at doses of 30, 100, and 300 mg/kg over a time period of 14 days resulted in altered thyroid cell follicular morphology and reduced size of follicular cells due to hypertrophy and unorganized growth. Interestingly, these doses of açaí oil also caused hepatocyte vacuolization, as well as a shift from eosinophilic to basophilic characteristics in the cells.…”

Section: Toxicity and Safety Studiesmentioning

confidence: 99%

Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

et al. 2023

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The açaí palm (Euterpe oleracea Mart.), a species belonging to the Arecaceae family, has been cultivated for thousands of years in tropical Central and South America as a multipurpose dietary plant. The recent introduction of açaí fruit and its nutritional and healing qualities to regions outside its origin has rapidly expanded global demand for açaí berry. The health-promoting and disease-preventing properties of this plant are attributed to numerous bioactive phenolic compounds present in the leaf, pulp, fruit, skin, and seeds. The purpose of this review is to present an up-to-date, comprehensive, and critical evaluation of the health benefits of açaí and its phytochemicals with a special focus on cellular and molecular mechanisms of action. In vitro and in vivo studies showed that açaí possesses antioxidant and anti-inflammatory properties and exerts cardioprotective, gastroprotective, hepatoprotective, neuroprotective, renoprotective, antilipidemic, antidiabetic, and antineoplastic activities. Moreover, clinical trials have suggested that açaí can protect against metabolic stress induced by oxidation, inflammation, vascular abnormalities, and physical exertion. Due to its medicinal properties and the absence of undesirable effects, açaí shows a promising future in health promotion and disease prevention, in addition to a vast economic potential in the food and cosmetic industries.

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Cytotoxic effects of Euterpe oleraceae fruit oil (açaí) in rat liver and thyroid tissues

Cited by 15 publications

References 21 publications

Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement

Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement

Emerging Lipids from Arecaceae Palm Fruits in Brazil

Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

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