Volatile oil of Croton zehntneri per oral sub-acute treatment offers small toxicity: perspective of therapeutic use

Coelho‐de‐Souza, Andrelina Noronha; Rocha, Maria V.A.P.; Oliveira, Keciany Alves de; Vasconcelos, Yuri A.G.; Santos, Edgleyson C.; Silva‐Alves, Kerly Shamyra da; Diniz, LÃ°cio Ricardo L.; Ferreira-da-Silva, Francisco Walber; Oliveira, A.C.; Ponte, Edson Lopes da; Evangelista, JanaÃ-na Serra-Azul M.; Assreuy, Ana Maria Sampaio; Leal‐Cardoso, J. H.

doi:10.1016/j.bjp.2018.11.005

Cited by 8 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data is also important because EOCz-induced prevention of increase in respiratory Newtonian resistance in anaphylaxis [24] does not necessarily lead to conclusion of antispasmodic effect, since the increase in Newtonian resistance could largely result from increase in airway secretions. It is noteworthy that EOCz and anethole are documented to have very low toxicity [13,16,46] which makes these agents potential candidates for therapeutic use.…”

Section: Discussionmentioning

confidence: 99%

“…Essential oil of Croton zehntneri (EOCz) has well-described pharmacological and biological activities, such as antielmintic [9], bactericidal [10], antifungal [11] and larvicide [12]. It has a low acute and subacute toxicity [13]. Among the main terpenoid compounds present in EOCz are trans-anethole (trans-1-methoxy-4-(1-propenyl)benzene, a colorless anise-flavored liquid 10 times sweeter than sugar and estragol (1-allyl-4-methoxybenzene), an isomer of anethole [14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle

Lima

Holanda-Angelin-Alves

Pereira-Gonçalves

et al. 2020

Heliyon

Self Cite

View full text Add to dashboard Cite

Croton zehntneri is a plant well adapted to the semi-arid climate of northeastern region of Brazil. The essential oil of C. zehntneri (EOCz) has been described to have several pharmacologic properties, including effect on airflow resistance of in vivo respiratory system. For this reason, we investigated the hypothesis that EOCz and its major constituents, anethole and estragole, have antispasmodic activity on tracheal muscle. In tracheal rings of Wistar rats, maintained in Krebs-Henseleit's solution, EOCz, anethole and estragole inhibited contractions induced by 60mM [K þ ], ACh (10μM), Ba 2þ and Phorbol dibutirate (1 μM). For EOCz, anethole and estragole, the IC 50 for inhibition of KCl-induced contractions were 145.8 AE 14.8, 89.9 AE 7.4 and 181.0 AE 23.3 μg/mL, respectively, and for ACh-induced contraction, they were 606.1 AE 122.0, 160.5 AE 33.0 and 358.6 AE 49.2 μg/mL. Pharmacodynamic efficacy was maximal in all cases. These data in Ba 2þ -induced contraction and the differential IC 50 suggested that blockade of Voltage Dependent Calcium Channels (VDCC) is a component of the mechanism of action of the three agents. Evaluation of the direct effect of anethole, on VDCC, showed inhibition of the Ca 2þ current through this type of channel. These results show that EOCz and the constituents have antispasmodic activity and the mechanism includes blockade of VDCC channels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle

Lima

Holanda-Angelin-Alves

Pereira-Gonçalves

et al. 2020

Heliyon

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, EOCz has low toxicity documented in sub-chronic administration (dosed 1–300 mg/kg, p.o.) and in acute studies (its LD50 was 3.5 g/kg, oral route), a property which increases the potentiality of this essential oil for use in DN therapy [ 22 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil of Croton zehntneri Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve

Silva‐Alves

Ferreira-da-Silva

Coelho‐de‐Souza

et al. 2021

Plants

Self Cite

View full text Add to dashboard Cite

Autonomic diabetic neuropathy (ADN) is a complication of diabetes mellitus (DM), to which there is no specific treatment. In this study, the efficacy of the essential oil of Croton zehntneri (EOCz) in preventing ADN was evaluated in the rat vagus nerve. For the two fastest conducting myelinated types of axons of the vagus nerve, the conduction velocities and rheobase decreased, whilst the duration of the components of the compound action potential of these fibers increased. EOCz completely prevented these DM-induced alterations of the vagus nerve. Unmyelinated fibers were not affected. In conclusion, this investigation demonstrated that EOCz is a potential therapeutic agent for the treatment of ADN.

show abstract

“…The chemical composition of the essential oil of C. zehntneri, evaluated by gas chromatography coupled with mass spectrometry, obtained as results the presence of trans-anethole (85.7%), estragole (4.8%), 1,8-cineole (2.95%), β-myrcene (2.2%), anisaldehyde (1.22%), trans-caryophyllene (0.9%), and some unidentified compounds (2.23%) (Coelho-de Souza et al, 2019). Diaz et al (2019) performed a characterization of the ethyl acetate fraction of Croton linear by high performance liquid chromatography, and identified seven new compounds for the specie, the alkaloids laudanidin, laudanosine, reticulin, coridin, glaucine and cularin, and glycosylated flavonoids.…”

Section: Chemical Compositionmentioning

confidence: 99%

Croton sp.: a review about Popular Uses, Biological Activities and Chemical Composition

Guerra

Ferreira

Oliveira

et al. 2022

RSD

View full text Add to dashboard Cite

The genus Croton, belonging to the Euphorbiaceae family, is a plant with shrubby characteristics, with the ability to regrow in times of rain, develops wildly, especially in deforestation areas, being reported mainly in the Caatinga and Forest region. One of the main characteristics of this genus is that several species are rich in chemical constituents of importance for medicine. In this way, this review of the literature, has an objective that findings regarding the biological activities and chemical composition of Croton species. This study is a literature review, carried out in the following databases: SciELO, BVS, MEDLINE, LILACS, PubMed and ScienceDirect, with a time frame between 1997 and 2020. The articles studied have shown different activities for Croton species, such as anti-inflammatory, antihypertensive, antifungal, antimicrobial, antidiabetic, antioxidant, antinociceptive and anti-tumor. Regarding toxicological aspects, the findings suggest caution in the use of Croton species, as some are toxic. While, regarding the chemical composition, in most species the presence of several secondary metabolites is observed, such as alkaloids, terpenoids, flavonoids and other phenolic compounds. Therefore, the results described in this article suggest that the therapeutic application of Croton species is supported by the literature, however we point out that caution is required in the use of Croton species, some present due to toxicity.

show abstract

Volatile oil of Croton zehntneri per oral sub-acute treatment offers small toxicity: perspective of therapeutic use

Cited by 8 publications

References 33 publications

Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle

Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle

Essential Oil of Croton zehntneri Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve

Croton sp.: a review about Popular Uses, Biological Activities and Chemical Composition

Contact Info

Product

Resources

About