Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants

Chinsembu, Kazhila C.

doi:10.1016/j.bjp.2018.10.006

Cited by 43 publications

(32 citation statements)

References 236 publications

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“…Antiviral effects have been reported. A weak inhibition of HIV reverse transcriptase activity has been described with HNK [ 32 , 33 ], as well as an activity against influenza virus sialidase, but also very limited [ 34 ]. The activity of HNK against different Herpes viruses is modest, with a minimal margin between the active dose and the cytotoxic dose [ 35 ].…”

Section: Pharmacological Profile Of Hnkmentioning

confidence: 99%

Hinokiflavone and Related C–O–C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action

Goossens

Bailly

2021

Nat. Prod. Bioprospect.

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Biflavonoids are divided in two classes: C–C type compounds represented by the dimeric compound amentoflavone and C–O–C-type compounds typified by hinokiflavone (HNK) with an ether linkage between the two connected apigenin units. This later sub-group of bisflavonyl ethers includes HNK, ochnaflavone, delicaflavone and a few other dimeric compounds, found in a variety of plants, notably Selaginella species. A comprehensive review of the anticancer properties and mechanism of action of HNK is provided, to highlight the anti-proliferative and anti-metastatic activities of HNK and derivatives, and HNK-containing plant extracts. The anticancer effects rely on the capacity of HNK to interfere with the ERK1-2/p38/NFκB signaling pathway and the regulation of the expression of the matrix metalloproteinases MMP-2 and MMP-9 (with a potential direct binding to MMP-9). In addition, HNK was found to function as a potent modulator of pre-mRNA splicing, inhibiting the SUMO-specific protease SENP1. As such, HNK represents a rare SENP1 inhibitor of natural origin and a scaffold to design synthetic compounds. Oral formulations of HNK have been elaborated to enhance its solubility, to facilitate the compound delivery and to enhance its anticancer efficacy. The review shed light on the anticancer potential of C–O–C-type biflavonoids and specifically on the pharmacological profile of HNK. This compound deserves further attention as a regulator of pre-mRNA splicing, useful to treat cancers (in particular hepatocellular carcinoma) and other human pathologies.

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Section: Pharmacological Profile Of Hnkmentioning

confidence: 99%

Hinokiflavone and Related C–O–C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action

Goossens

Bailly

2021

Nat. Prod. Bioprospect.

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“…The need for medicinal plants and other natural products to treat COVID-19 patients is urgent especially in Africa where health systems grapple with high caseloads of HIV/AIDS and malaria in addition to being heavily under-resourced in terms of funding and staff. Overall, plants with antiplasmodial (Chinsembu 2015 ), anti-tuberculosis (Chinsembu 2016b ), and anti-HIV replication (Chinsembu 2019 ) activities may present good prospects for the discovery of new active compounds with anti-SARS-CoV-2 action. Pechuel-loeschea leubnitziae O. Hoffm.…”

Section: Perspective On Future Directionsmentioning

confidence: 99%

“…To prevent author bias, this review was carried out using a comprehensive and systematic data mining approach similar to that used by Chinsembu ( 2019 ). To obtain pertinent literature, the key words “SARS” and “medicinal plants” were concomitantly searched in Google Scholar, Elsevier’s pay-to-view service Science Direct, Scopus, Scielo, and PubMed Central, the US National Library of Medicine’s digital archive of biomedical and life sciences journal literature.…”

Section: Introductionmentioning

confidence: 99%

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Chinsembu

2020

Rev. Bras. Farmacogn.

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Current challenges to the treatment of coronavirus disease 2019 should open new prospects in the search for novel drugs from medicinal plants and other natural products. This paper provides details of natural agents that inhibit human coronavirus entry into cells, general replication, and specific chymotrypsin-like protease (3CL pro)-mediated replication. Medicinal plants, fungi, and marine organisms as remedies for human coronaviruses in China, Lebanon, Malaysia, Singapore, and South Africa are described. Common species include Alnus japonica (Thunb.

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“…(1), ASP623 29 . Our study demonstrated that this molecule shows a promising anti-SARS-CoV-2 polymerase activity, forming nine-strong H bonding, picationic, and pi-anionic interaction with four amino acids, and pi-alkyl bond (Table 3 and Figure 4).…”

Section: Docking and Interaction Analysismentioning

confidence: 99%

Potential activity of a selected natural compounds on SARS-CoV-2 RNA-dependent-RNA polymerase, and binding affinity of the receptor-binding domain (RBD)

Altayeb

Bouslama

Abdulhakimc

et al. 2020

Preprint

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Coronavirus disease (COVID-19) is caused by SARS-CoV-2 and represents the causative agent of a potentially lethal disease. COVID-19 has been described as a significant global public health pandemic by the World Health Organization due to its high mortality rate, rapid spread, and the lack of drugs and vaccines for it. Active antiviral drugs are desperately needed to combat the potential return of severe acute respiratory syndrome (SARS).In this study, we selected 39 natural compounds present in plants, algae, and sponges with antiviral activity. Molecular docking was used to screen the compounds’ activity on SARS- CoV-2 RNA-dependent-RNA polymerase, receptor-binding domain (RBD), and the human ACE2 receptor. Compounds with binding energy ≤ -6.5 kcal/mol enter pre-clinical testing using in silco ADME/Tox (absorption, distribution, metabolism, excretion, and toxicity).We found eight potential SARS-CoV-2 inhibitors: (glycyrrhizin, rutin, baicalin, 1, 6-di-O- galloyl-beta-D-glucose, pyropheophorbide A, pheophorbide A, beta-Sitosterol, and vitexin). These outcomes indicate that these compounds could be potential candidates to be utilized in lead optimization for the design and production of the anti-SARS-CoV-2 drug.

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Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants

Cited by 43 publications

References 236 publications

Hinokiflavone and Related C–O–C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action

Hinokiflavone and Related C–O–C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Potential activity of a selected natural compounds on SARS-CoV-2 RNA-dependent-RNA polymerase, and binding affinity of the receptor-binding domain (RBD)

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