Lupin gamma conglutin protein: effect on Slc2a2, Gck and Pdx-1 gene expression and GLUT2 levels in diabetic rats

Effect of Lupinus rotundiflorus gamma conglutin treatment on JNK1 gene expression and protein activation in a rat model of type 2 diabetes

“…Differences in Cc lupine species have emphasized the importance of verifying the biological effects of Cc among species (Foley et al 2015;Mane et al 2018). In previous studies, Cc extracted from L. albus (domesticated species) was evaluated using the same treatment period (one week) and dose (120 mg/ kg/day) employed in the present study, and a reduction of 17-27% in serum glucose levels was reported (Vargas-Guerrero et al 2014;Gonz alez-Santiago et al 2017;Sandoval-Muñ ız et al 2018). In another study using male Sprague-Dawley rats, the administration of 28 mg/kg of Cc from L. albus for three weeks reduced glucose levels by 22% compared with those without treatment (Lovati et al 2012).…”

“… 2017 ; Sandoval-Muñíz et al. 2018 ). In another study using male Sprague-Dawley rats, the administration of 28 mg/kg of Cγ from L. albus for three weeks reduced glucose levels by 22% compared with those without treatment (Lovati et al.…”

“…The Cc protein has obtained special interest due its hypoglycaemic activity, which has been already demonstrated in vitro, in vivo, and in human participants in clinical trials (Magni et al 2004;Bertoglio et al 2011;Lovati et al 2012;Vargas-Guerrero et al 2014;Mane et al 2018). Although, the effects of lupine Cc on several molecules involved in the glucose metabolism have been evaluated (Vargas-Guerrero et al 2014;Gonz alez-Santiago et al 2017;Muñoz et al 2018;Sandoval-Muñ ız et al 2018), its full mechanism of action remains unknown. Besides, most studies have focussed on domesticated lupine species, the knowledge available on Cc from wild lupines is still limited.…”

“… 2018 ; Sandoval-Muñíz et al. 2018 ), its full mechanism of action remains unknown. Besides, most studies have focussed on domesticated lupine species, the knowledge available on Cγ from wild lupines is still limited.…”

Grain Proteins: Challenges and Solutions in Developing Consumer-Relevant Foods

“…Other grain proteins are also gaining traction, including sweet lupin and fava proteins. Sweet lupin is a low-cost source of proteins with a protein content similar to that of soy, and its derived bioactive peptides are associated with several health-related benefits (e.g., hyperglycemia, hypertension, and cholesterol lowering) (7,8,27,33,39,48). Studies have been carried out to enhance lupin protein functionality (e.g., solubility, emulsification, and foaming activity) through the application of proteolytic enzymes in order to match that of soy (50).…”