In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum

In Vitro Evaluation of Hydroalcoholic Extracts of Capparis spinosa, Ricinus communis, and Solanum luteum on Leishmania major (MRHO/IR/75/ER) Promastigotes

“…Azaizeh et al showed that S. nigrum L. extract, when used as a foliage originating decoction, can be used as a Wound and sunburn treatment (21). Clementino et al studied Solanum lycocarpum glycoalkaloids activity against promastigotes of L. infantum (anti-Leishmania activity) in in vitro conditions (22). They isolated alkaloids solasodine, solamargine, and solasonine against promastigotes and intracellular amastigotes of L. infantum (22).…”

“…Clementino et al studied Solanum lycocarpum glycoalkaloids activity against promastigotes of L. infantum (anti-Leishmania activity) in in vitro conditions (22). They isolated alkaloids solasodine, solamargine, and solasonine against promastigotes and intracellular amastigotes of L. infantum (22). Previous Researchers reported the antileishmanial activity of extracts obtained from other Solanum species (23)(24)(25)(26)(27).…”

Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S.Geep) indicates 13E-Docosenamide as potential antileishmanial agent

“…Additionally, the ratio of antiamastigote activity to host cell toxicity, the selective index (SI = CC 50macrophages /IC 50 amastigote ) was determined. The infection index was determined according to Clementino et al (2018) study. Statistical significant differences between treatments using 13E-docosenamide and control (untreated cells) were determined using "a one-way analysis" of variance, by Tukey's multiple comparison test (GraphPad Prism software).…”

Análisis estructural de interacciones in silico de fitoconstituyentes de Solanum americanum, Solanum guaraniticum y Solanum lycopersicum con la proteína tripanotiona reductasa de Leishmania infantum

“…Las actividades leishmanicidas de la solasodina fueron atribuidas a las propiedades fisicoquímicas de la molécula, ya que por su carácter principalmente hidrofóbico permitiría a estas moléculas atravesar la membrana plasmática de la L. infantum rica en glicoproteínas ancladas con glicosilfosfatidilinositol, y una vez dentro del citoplasma del parásito interactuar con posibles blancos proteicos (Cham y Daunter, 1990;Clementino et al, 2018;Ndjakou Lenta et al, 2007).…”

“…Recientemente, Alvarenga et al (2020) han demostrado que el extracto metanólico de S. americanum Mill., y sus fraccionamientos en cloroformo y en acetato de etilo presentan actividades antiprotozoarias contra L. infantum, demostrando reducciones en la cantidad de protozoarios en un 74-98% a concentraciones de 50-100 μg.mL -1 . De igual manera, Clementino et al (2018) han reportado que los glicoalcaloides esteroidales (solasonina, solasodina y solamargina) que se encuentran en la especie S. lycocarpum A. St.-Hil. presentan actividades leishmanicidas in vitro contra promastigotes y amastigotes de L. infantum.…”