Background: Plant extracts or compounds derived from plants are a valuable source for finding new anti-leishmaniasis drugs. Objective: In this study, Capparis spinosa L., Ricinus communis, and Solanum luteum were used as lethal agents for the promastigotes of Leishmania major parasites in the culture medium. Methods: Diluted extracts of 12.5, 100, and 500 mg/mL were prepared from medicinal plant dried extracts. Glucantime at a concentration of 500 mg/mL was used as a positive control. Results: For all three extracts, concentrations of 100 and 500 mg/mL could kill promastigotes at higher rates and speeds compared to other concentrations. The high concentrations of extracts (500 mg/mL) presented similar effects. According to the findings, hydroalcoholic extract of C. Spinosa L. presented considerably lower antiparasitic effects, and S. luteum and R. communis extracts were could kill most of the parasitic promastigotes at higher doses. The ANOVA test did not show any significant viability percentage difference of Leishmania extracts between different extract types. Conclusions: In this study, the lethal effects of R. communis and S. luteum hydroalcoholic extracts on L. major promastigotes were found to be stronger than the C. Spinosa L. extract.
Turmeric extract and aroma oil of Curcuma longa exhibit inhibition properties against various bacteria, parasites, and pathogenic fungi. We investigated the effects of Ginger (Zingiber officinale) and Turmeric extract on Leishmania promastigotes and used gas chromatography-mass spectrometry (GC-MS) for analyzing plant extracts. The hydroalcoholic extractions obtained from the two plants were diluted in 70% ethanol to three different concentrations; 12.5, 100, and 500 mg mL-1. The Leishmania significant strains were propagated in an artificial medium to reach sufficient parasites. The survival percentage of Leishmania promastigotes was affected significantly by the time and concentration of the extracts (P < 0.05). The repeated measures pattern showed an interaction effect between various time points and treatment with the extracts. Statistics analysis showed a significant difference between different concentrations and extract samples (P < 0.05). GC-MS showed that the survival rate of Leishmania promastigotes treated with hydroalcoholic extract of Ginger at 3-time points (24, 48, and 72 hours) was lower than Glucantime and Turmeric extract. The survival rate of promastigotes treated with Turmeric extract was similar to those treated with Glucantime but lower than those treated with a combined extract of Ginger and Turmeric at a concentration of 500 mg mL-1.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.