Evaluation of hepatoprotective activity of Syringa oblata leaves ethanol extract with the indicator of glutathione S -transferase A1

Li, Ying; Li, Zhi; Li, Changwen; Ma, Xin; Chang, Yicong; Shi, Chenxi; He, Jingshan; Li, Rui; Ishfaq, Muhammad; Liu, Fangping

doi:10.1016/j.bjp.2018.05.011

Cited by 7 publications

(1 citation statement)

References 31 publications

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“…has long been used to treat diseases such as vomiting, nausea, diarrhea, rheumatic pain, and kidney deficiency [ 23 ]. Modern pharmacological studies confirmed that the leaves of S. oblata , extensively applied to treat various inflammatory illnesses and the activities mentioned above, might attribute to iridoid glycosides, which, as physiologically active substances, showed remarkable activities [ 24 ]. Yan Li Xiao (YLX) capsule is one of the commercial medicines and mainly consists of water extract and powder of S. oblata leaves.…”

Section: Introductionmentioning

confidence: 99%

Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells

Zhu

Sun

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Acute pharyngitis is an inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues. Unsatisfactory treatment and repeated occurrences might cause chronic pharyngitis and other complications. Syringa oblata L. (S. oblata) is a traditional Chinese medicine that exhibited a significant therapeutic effect on various inflammatory diseases. Its commercial drug Yan Li Xiao (YLX) capsule is used as a cure for the treatment of inflammatory diseases, such as bacillary dysentery, tonsillitis, bronchitis, and acute gastroenteritis. However, studies about S. oblata relieving acute pharyngitis are rare. In this study, high-performance liquid chromatography (HPLC) was used to analyze the chemical profile of S. oblata, and the bioactive phytoconstituents were isolated and identified by nuclear magnetic resonance (NMR) and mass spectrometry. An ammonia-induced acute pharyngitis rat model was established to estimate the protective effect of S. oblata in vivo for the first time. The severity of pharyngitis was observed by appearance index and HE staining. The cytokines expression was performed by ELISA. Crucial proteins expression associated with TLR4/NF-κB/MAPK and NLRP3 inflammasome signaling pathways were analyzed by western blotting and immunohistochemistry. Furthermore, the anti-inflammatory effect of isolated compounds was evaluated by suppressing lipopolysaccharide- (LPS-) induced NO generation and regulating the cytokines levels in RAW 264.7 cells. The results showed that S. oblata exhibited a protective effect in the ammonia-induced acute pharyngitis rat model, and the compounds exert potential anti-inflammatory properties against LPS-activated RAW 254.7 cells.

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Section: Introductionmentioning

confidence: 99%

Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells

Zhu

Sun

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Acetaminophen‐induced hepatocyte injury: C2‐ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S‐transferase A1 changes

Chang

Wang

Yang

et al. 2019

J of Applied Toxicology

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Acetaminophen (APAP) is an antipyretic and analgesic, which is commonly associated with drug‐induced hepatic injury. C2‐ceramide plays a key role in mediating cell life activities, and oltipraz was extensively studied as a cancer chemopreventive agent. Glutathione S‐transferase A1 (GSTA1) acts as a vital liver detoxification enzyme. Hepatocyte nuclear factor 1 (HNF‐1) regulates various cellular signaling pathways. In this study, we investigated the effects of C2‐ceramide and oltipraz on APAP‐induced hepatocyte injury and the changes of HNF‐1 and GSTA1. Results showed that C2‐ceramide (6 μmol/L) exacerbated APAP‐induced hepatocyte injury and caused a significant decrease (P < .01) in HNF‐1 and GSTA1 expressions. Meanwhile, GSTA1 content in supernatant was significantly increased (P < .01). In contrast, oltipraz (8 μmol/L) reduced the injury and significantly elevated (P < .01) HNF‐1 and GSTA1 expressions while GSTA1 content in supernatant was significantly decreased (P < .01). In conclusion, these findings revealed that C2‐ceramide inhibited HNF‐1 and GSTA1 expression and exacerbated hepatocyte injury, while oltipraz treatment results in the reduction of hepatocyte injury, and promoted HNF‐1 and GSTA1 expression. Additionally, the changes in HNF‐1 and GSTA1 were related to APAP‐induced hepatocyte injury. These results were useful to investigate the mechanism of an antipyretic and analgesic drug combination.

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The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review

Parthasarathy

Sabina

2021

Mol Biol Rep

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Evaluation of hepatoprotective activity of Syringa oblata leaves ethanol extract with the indicator of glutathione S -transferase A1

Cited by 7 publications

References 31 publications

Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells

Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells

Acetaminophen‐induced hepatocyte injury: C2‐ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S‐transferase A1 changes

The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review

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