The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review

Parthasarathy, Manisha; Sabina, Evan Prince

doi:10.1007/s11033-021-06444-4

Cited by 16 publications

(9 citation statements)

References 117 publications

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“…Plants contain secondary metabolites that are widely used in treating disease conditions [47]. These compounds are known to stimulate biochemical reactions in cells [48].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity and Mechanism of Cryptochlorogenic Acid from Ageratina adenophora

Okyere

et al. 2022

Nutrients

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Ageratina adenophora is an invasive plant known for its toxicity to livestock. Current research on this plant has shifted from toxicity prevention to the beneficial utilization of plant resources. This study was performed to investigate the effects and mechanisms of cryptochlorogenic acid (CCGA) isolated from Ageratina adenophora on the inflammatory responses induced by lipopolysaccharide (LPS) in RAW264.7 cells. RAW264.7 cells were pretreated with CCGA (200, 100, and 50 μg/mL) and subsequently stimulated with LPS (1 μg/mL) for 16 h. The cytotoxicity of CCGA was tested using the Cell Counting Kit (CCK8). The mechanism of action of CCGA in attenuating inflammation was also identified using enzyme-linked immunosorbent assay (ELISA), quantitative reverse transcription-polymerase chain reaction, and Western blot. The results showed that CCGA had a maximal safe concentration of 200 mg/mL. Moreover, CCGA reduced the level of nitric oxide (NO) and iNOS in LPS-induced RAW264.7 cells (p < 0.01). In addition, CCGA reduced the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) and cyclooxygenase-2 (COX-2) in LPS-induced RAW264.7 cells at both the mRNA and protein levels (p < 0.01). CCGA prevented the activation of nuclear factor-kappa B (NF-kB) in LPS-induced RAW264.7 cells via the inhibition of IKK and IκB phosphorylation and the degradation of IκB proteins (p < 0.01). This finding indicated that CCGA isolated from A. adenophora may be a potential candidate for the treatment of inflammation-related diseases.

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“…Plants contain secondary metabolites that are widely used in treating disease conditions [47]. These compounds are known to stimulate biochemical reactions in cells [48].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity and Mechanism of Cryptochlorogenic Acid from Ageratina adenophora

Okyere

et al. 2022

Nutrients

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“…The hepatoprotective effects against CCl 4 -induced liver damage by natural products are supported by numerous published studies (Pan et al, 2020;Parthasarathy & Evan Prince, 2021;Ugwu & Suru, 2021). Different classes of dietary natural products may modulate the endogenous antioxidant system to ameliorate toxins-induced liver damage.…”

Section: Introductionmentioning

confidence: 93%

Hepatoprotective effects of Niudali (Callerya speciosa) root aqueous extracts against tetrachloromethane‐induced acute liver injury and inflammation

Zhang,

Huang,

Gan

et al. 2023

Food Science & Nutrition

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Niudali (Callerya speciosa) is commonly grown in southeastern regions of China and consumed as a food ingredient. Although Niudali root extracts showed various biological activities, the hepatoprotective effects of Niudali root phytochemicals are not fully studied. Herein, we prepared two Niudali root aqueous extracts, namely, c and Niudali polysaccharides‐enriched extract (NPE), and identified an alkaloid, (hypaphorine) in NEW. The hepatoprotective effects of NWE, NPE, and hypaphorine were evaluated in an acute liver injury model induced by carbon tetrachloride (CCl4) in mice. Pathohistological examination and blood chemistry assays showed that treatment of NWE, NPE, and hypaphorine alleviated CCl4‐induced liver damage by lowering the liver injury score (by 75.51%, 80.01%, and 41.22%) and serum aspartate and alanine transaminases level (by 63.24%, 85.22%, and 49.74% and by 78.73%, 80.08%, and 81.70%), respectively. NWE, NPE, and hypaphorine also reduced CCl4‐induced hepatic oxidative stresses in the liver tissue by decreasing the levels of malondialdehyde (by 40.00%, 51.25%, and 28.75%) and reactive oxygen species (by 30.22%, 36.14%, and 33.54%) while increasing the levels of antioxidant enzymes including superoxide dismutase (by 21.36%, 21.64%, and 8.90%), catalase (by 22.13%, 33.33%, and 5.39%), and glutathione (by 84.87%, 90.65%, and 80.53%), respectively. Mechanistic assays showed that NWE, NPE, and hypaphorine alleviated liver damage by mediating inflammatory biomarkers (e.g., pro‐inflammatory cytokines) via the signaling pathways of mitogen‐activated protein kinases and nuclear factor‐κB. Findings from our study extend the understanding of Niudali's hepatoprotective effects, which is useful for its development as a dietary intervention for liver inflammation.

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“…The benefits of employing phytochemicals in cancer treatment may include exerting pharmacological effect at low dosages 118 and fewer side effects. 119 Although these phytochemicals may not be as efficacious as current drugs, their development as therapeutic adjuvants could be an alternative that may enhance treatment efficiency and reduce drug use.…”

Section: Phytochemicals Impair Mitochondria To Achieve Cancer Preventionmentioning

confidence: 99%

The Role of Mitochondria in Phytochemically Mediated Disease Amelioration

Koh

Pan

2023

J. Agric. Food Chem.

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Mitochondrial dysfunction may cause cell death, which has recently emerged as a cancer prevention and treatment strategy mediated by chemotherapy drugs or phytochemicals. However, most existing drugs cannot target cancerous cells and may adversely affect normal cells via side effects. Mounting studies have revealed that phytochemicals such as resveratrol could ameliorate various diseases with dysfunctional or damaged mitochondria. For instance, resveratrol can regulate mitophagy, inhibit oxidative stress and preserve membrane potential, induce mitochondrial biogenesis, balance mitochondrial fusion and fission, and enhance the functionality of the electron transport chain. However, there are only a few studies suggesting that phytochemicals could potentially protect against the cytotoxicity of some current cancer drugs, especially those that damage mitochondria. Besides, COVID-19 and long COVID have also been reported to be correlated to mitochondrial dysfunction. Curcumin has been reported bringing a positive impact on COVID-19 and long COVID. Therefore, in this study, the benefits of resveratrol and curcumin to be applied for cancer treatment/prevention and disease amelioration were reviewed. Besides, this review also provides some perspectives on phytochemicals to be considered as a treatment adjuvant for COVID-19 and long COVID by targeting mitochondrial rescue. Hopefully, this review can provide new insight into disease treatment with phytochemicals targeting mitochondria.

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The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review

Cited by 16 publications

References 117 publications

Anti-Inflammatory Activity and Mechanism of Cryptochlorogenic Acid from Ageratina adenophora

Anti-Inflammatory Activity and Mechanism of Cryptochlorogenic Acid from Ageratina adenophora

Hepatoprotective effects of Niudali (Callerya speciosa) root aqueous extracts against tetrachloromethane‐induced acute liver injury and inflammation

The Role of Mitochondria in Phytochemically Mediated Disease Amelioration

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