Phytochemical analysis of Juglans regia oil and kernel exploring their antinociceptive and anti-inflammatory potentials utilizing combined bio-guided GC–FID, GC–MS and HPLC analyses

Raafat, Karim

doi:10.1016/j.bjp.2018.03.007

Cited by 18 publications

(11 citation statements)

References 21 publications

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“…These results are in compliance with the obtained MICs. Literature has suggested that active ingredients present in Juglans regia may include juglone, regiolone, glansreginin A, glansreginin B and proceroside [ 57 , 58 , 59 ] ( Table 5 ), that may be contributing to inhibition.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Plant Origin Antibiotics against Oral Bacterial Infections Using In Vitro and In Silico Techniques and Characterization of Active Constituents

et al. 2021

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The pervasiveness of oral bacterial infections in diabetic patients is a serious health concern that may produce severe complications. We investigated 26 Ayurvedic medicinal plants traditionally used for treatment of the oral bacterial infections with the aim to look for new promising drug leads that can be further employed for herbal formulation design. The plants were grouped into three categories based on traditional usage. All plant extracts were examined for antibacterial, antibiofilm and antiquorum-sensing properties. The plants with significant activities including Juglans regia, Syzygium aromaticum, Eruca sativa, Myristica fragrans, Punica granatum and Azadirachta indica were further analyzed using HPLC-DAD-QToF and GC-MS. In silico and in vitro activity was evaluated for selected constituents. Finally, it could be concluded that eugenol and 2-phenylethylisothiocyanate are major contributors towards inhibition of bacterial biofilms and quorum sensing.

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Section: Resultsmentioning

confidence: 99%

Analysis of Plant Origin Antibiotics against Oral Bacterial Infections Using In Vitro and In Silico Techniques and Characterization of Active Constituents

et al. 2021

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“…It was not possible to establish the lethal dose. [8][9][10][11] was determined toxic doses (mice manifested in a number of diarrhea TD 50 = 2,5). Experimental animals received the drug inside the maximum possible dose based on the capacity of the stomach experimental animal.…”

Section: Resultsmentioning

confidence: 99%

Study of Quality Medicinal Plants Bark Walnuts and Extract from it

Av¹,

Di²,

Луферов³

et al. 2020

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Objective: The bark of walnut is currently poorly understood and is not represented in the Russian State Pharmacopeia. The purpose was to study the quality indicators medicinal plants walnut crust and extracts therefrom were studied: moisture content, total ash, ash insoluble in 10% hydrochloric acid feedstock walnut crust; content of tannins and juglone in walnut crust; GC-mass spectrometric study of the composition petroleum extract from the bark of a walnut. Materials and Methods: Microscopy was prepared by the pharmacopoeial method. The chemical composition of the petroleum extract was investigated by chromatomass spectrometry. Results: The content of glycosides amount in terms of gidroyuglone glucoside and absolutely dry RL was 5.30 ± 0.15. Humidity was 9,41% ± 0,21. total ash content was 10,18% ± 0,1. The ash content insoluble in 10% hydrochloric acid was 4.8 ± 0.16. Gas chromatography-mass spectrometry method in petroleum extraction from the bark of walnut were identified following compounds: oktadetsilgeksanoat (28%) of 4-isopropenyl-1-methyl-2-cyclohexenol-1 (38%), cineole (1,6%), thujone (0.7%), camphor (16.6%), 2benzamidoantrahinone (0.45%), 4,5-dihydroxy-3,4-dihydro-1 (2H)-naftalenon (6.4%) ethyl ester of palmitic acid (8.25%) Toxic effects petroleum extract was TD 50 = 2,5. Chronic absent. All mice in the experimental group had diarrhea. It was established that the extraction has petroleum anthelmintic properties at askaridioze. Conclusions: The analysis of petroleum extraction from walnut partitions was carried out, the content of basic biologically active substances was revealed. The main anatomical and diagnostic signs of walnut bark walls were studied.

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“…Glansreginin A has been also found in the kernels of three other nuts including English walnut [23,49,54,55], pecans ( Carya illinoinensis ) [71], and hazelnut ( Corylus avellana ) [50]. Due to the presence of this compound in the kernels of these nuts, glansreginin A has been linked to multiple biological activities in vitro and in vivo such as antioxidant [49,50,72], anti-inflammatory [51], antiatherogenic effect [52], and antinociceptive effect [53], reduction of cholesterol absorption [54]. This is the first time, glansreginin A is reported to be associated with the antibacterial properties.…”

Section: Discussionmentioning

confidence: 99%

Identifying Antibacterial Compounds in Black Walnuts (Juglans nigra) Using a Metabolomics Approach

Lei

Sumner

et al. 2018

Metabolites

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Black walnut (Juglans nigra L.) is one of the most economically valuable hardwood species and a high value tree for edible nut production in the United States. Although consumption of black walnut has been linked to multiple health-promoting effects (e.g., antioxidant, antimicrobial, anti-inflammatory), the bioactive compounds have not been systematically characterized. In addition, the associations between different black walnut cultivars and their health-promoting compounds have not been well established. In this study, the kernels of twenty-two black walnut cultivars selected for nut production by the University of Missouri Center for Agroforestry (Columbia, MO, USA) were evaluated for their antibacterial activities using agar-well diffusion assay. Among the selected cultivars, four black walnut cultivars (i.e., Mystry, Surprise, D.34, and A.36) exhibited antibacterial activity against a Gram-positive bacterium (Staphylococcus aureus), whereas other cultivars showed no effect on the inhibition of this bacterium. The antibacterial compounds showing the strongest activity were isolated with bioassay-guided purification and identified using a metabolomics approach. Six antibacterial bioactive compounds responsible for antimicrobial activity were successfully identified. Glansreginin A, azelaic acid, quercetin, and eriodictyol-7-O-glucoside are novel antibacterial compounds identified in the kernels of black walnuts. The metabolomics approach provides a simple and cost-effective tool for bioactive compound identification.

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Phytochemical analysis of Juglans regia oil and kernel exploring their antinociceptive and anti-inflammatory potentials utilizing combined bio-guided GC–FID, GC–MS and HPLC analyses

Cited by 18 publications

References 21 publications

Analysis of Plant Origin Antibiotics against Oral Bacterial Infections Using In Vitro and In Silico Techniques and Characterization of Active Constituents

Analysis of Plant Origin Antibiotics against Oral Bacterial Infections Using In Vitro and In Silico Techniques and Characterization of Active Constituents

Study of Quality Medicinal Plants Bark Walnuts and Extract from it

Identifying Antibacterial Compounds in Black Walnuts (Juglans nigra) Using a Metabolomics Approach

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