РезюмеЦель исследования. Отразить достижения России и Узбекистана в изучении проблемы пециломикоза. В задачу исследований входила разработка диагностики и лечения пециломикоза легких (ПЦЛ). Материалы и методы. Обследовали 225 лиц, из них 200 больных с поражение бронхолегочной системы грибами рода Paecilomyces и 25 клинически здоровых (контроль). Использовали клинико-анамнестические, лабораторно-диагностические, микологические, иммунологические методы исследования; для дифференциальной диагностики применяли реакцию антигенсвязывания лимфоцитов. Пециломикозную инфекцию диагностировали на основании микроскопического исследования морфологии грибов в патологическом материале (кровь, мокрота) и выделения культуры грибов на питательных средах (Сабуро, Чапека). У 112 больных пециломикозом, осложненным гельминтозом, изучали тяжелое осложнение ПЦЛ -пециломикозный атипичный миокардит (ПАМ). Эти больные обследованы эхокардиографически по общепринятой методике. Результаты. Пециломикоз бронхолегочной системы, возникающий в результате первичного и вторичного инфицирования грибами рода Paecilomyces, клинически проявлялся в виде хронического обструктивного бронхита (11,5%), рецидивирующей пневмонии (13,5%), экзогенного аллергического альвеолита (37%), бронхиальной астмы (26%), осложненной гельминтозами (12%). Распространению пециломикоза способствует йодная недостаточность, а заражению пециломикозом -эхинококкоз, при этом сама капсула гельминта служит питательной средой для развития мицелиальной формы гриба. Тяжелым осложнением ПЦЛ являются ПАМ. Почти у 50% больных ПЦЛ проявлялись кардиты. При ПАМ больные временами испытывают страх и сильнейшую перемежающую боль. Сначала она возникала в грудной клетке, иррадиировала в подмышечную впадину, в левую руку до кончиков пальцев, парализуя руку. У некоторых больных боль появлялась в обеих руках с переходом в живот, сопровождаясь обмороками. Современные обезболивающие средства (мелоксикам, тизанидин, нимесулид, морфий, промедол) в сочетании с флуконазолом давали временный положительный эффект. Заключение. Для разработки схем эффективного снятия боли при ПАМ у больных ПЦЛ необходимы дальнейшие исследования, в которых должны участвовать также неврологи и анестезиологи.Ключевые слова: пециломикоз легких, лучевая диагностика, пециломикозный атипичный миокардит, пециломикоз, ослож-ненный гельминтозом, йодная недостаточность, лечение пециломикозного атипичного миокардита. Aim.To represent the advances of Russia and Uzbekistan in studying the problem of paecilomycosis. The goal of the investigation was to develop the diagnosis and treatment of pulmonary paecilomycosis (PP). Subjects and methods. Two hundred and twenty-five people, including 200 patients with bronchopulmonary infection with fungi of the Paecilomyces genus and 25 clinically healthy individuals (a control group), were examined. Clinico-anamnestic, laboratory diagnostic, mycological, and immunological studies were conducted; a lymphocyte antigen-binding test was used for differential diagnosis. Paecilomyces infection was diagnosed ...

Objective: The bark of walnut is currently poorly understood and is not represented in the Russian State Pharmacopeia. The purpose was to study the quality indicators medicinal plants walnut crust and extracts therefrom were studied: moisture content, total ash, ash insoluble in 10% hydrochloric acid feedstock walnut crust; content of tannins and juglone in walnut crust; GC-mass spectrometric study of the composition petroleum extract from the bark of a walnut. Materials and Methods: Microscopy was prepared by the pharmacopoeial method. The chemical composition of the petroleum extract was investigated by chromatomass spectrometry. Results: The content of glycosides amount in terms of gidroyuglone glucoside and absolutely dry RL was 5.30 ± 0.15. Humidity was 9,41% ± 0,21. total ash content was 10,18% ± 0,1. The ash content insoluble in 10% hydrochloric acid was 4.8 ± 0.16. Gas chromatography-mass spectrometry method in petroleum extraction from the bark of walnut were identified following compounds: oktadetsilgeksanoat (28%) of 4-isopropenyl-1-methyl-2-cyclohexenol-1 (38%), cineole (1,6%), thujone (0.7%), camphor (16.6%), 2benzamidoantrahinone (0.45%), 4,5-dihydroxy-3,4-dihydro-1 (2H)-naftalenon (6.4%) ethyl ester of palmitic acid (8.25%) Toxic effects petroleum extract was TD 50 = 2,5. Chronic absent. All mice in the experimental group had diarrhea. It was established that the extraction has petroleum anthelmintic properties at askaridioze. Conclusions: The analysis of petroleum extraction from walnut partitions was carried out, the content of basic biologically active substances was revealed. The main anatomical and diagnostic signs of walnut bark walls were studied.

Veronica beccabunga L. belongs to the class dicotyledons, order Lamiáles, family Scrophulariaceae. The scientific name of the genus Veronica dates back to antiquity and is already found in Roman and ancient Greek authors. B. N. Golovkin believes that the name Veronica was given in 1542 by the German botanist Leonart Fuchs (1501-1566) in honor of St. Veronica. 1-19 Species numbers vary between two and fifteen with many subspecies. Verоnica beccabunga L. is widespread. Western Europe: all countries south of 65 ° north latitude. Asia: Turkey, China. North America: USA, Canada. On the territory of the former USSR it is found from the western border to the southern part of the Ural Range, in the Caucasus, in Siberia. In the north reaches the Karelian Isthmus, the southern coasts of Lake Ladoga and Onega, the confluence of Sukhona and Vychegda, in the region of Pechora, Arkhangelsk. It is found in Crimea. 1 It grows along the banks of reservoirs, in streams, near springs, on key swamps, in places where groundwater emerges, i.e. is a hydrophyte (Figure 1 A, B). 6,8,20 Representatives of the genus Veronica have long been used in folk medicine as antiinflammatory, antibacterial, antiseptic, wound healing, hemostatic, choleretic and antispasmodic drugs. 14,17 Verоnica beccabunga L. is a member of the semi-aquatic plants. Researchers mentioned this medicinal plant in their scientific work, conducting morphometric and molecular studies based on plastid and nuclear ribosomal DNA groups. MATERIALS AND METHODS Several series of thin sections from the axial organs of the plant were made. Endoderm was also removed ABSTRACT Introduction: Veronica beccabunga L. belongs to the class dicotyledons, order Lamiáles, family Scrophulariaceae. Representatives of the genus Veronica have long been used in folk medicine as antiinflammatory, antibacterial, antiseptic, wound healing, hemostatic, choleretic and antispasmodic drugs. Widely studied species are Veronica officinalis and Veronica chamaedrys. Veronica beccabunga L., which is the object of our study, remains a poorly studied plant. Aim: The study of external signs, microscopy and chemical composition of medicinal plant materials of Verоnica beccabunga L. herb. Materials and Methods: Chromato-mass spectrometry was used in the work. Results and Discussion: When describing external signs and microscopy, diagnostic signs of Verоnica beccabunga were revealed. 27 compounds were identified by chromatography-mass spectrometry. The maximum content falls on: Citronellol epoxide (R or S) (30.5 %), Linolenic acid, ethyl ester (15.18), Diethyl succinate (12.17%), Ethyl palmitate (6.43%), Phytol (4.89%), Acetaldehyde ethyl amyl acetal (3.94%), Dibenzylamine (3.01%), Oleamide (2.77%), 2-(1-Methylbutyl)oxirane (2.7%), Butyl octyl phthalate(1.7%), Ethyl 10-bromodecanoate (1.68), Valeric acid, 4-methyl-, ethyl ester (1.58). Glycoside detected : 1-Benzyl-1Hbenzimidazole 3-oxide (0.76%). Conclusion: The revealed morphological and anatomical signs of Verоnica beccabunga herb can be used to diagnose this sp...

This paper presents the results of the review pharmacognostic study of common toothwort, a perennial plant, parasitizing on the roots of trees. Currently, in Russian traditional medicine, there is considerable experience in the use of сommon toothwort (Lathraea squamaria L.) herb and roots as antitumoral, biligenic, infertility-treatment and diuretic drugs. The chemical composition of L. squamaria has not been quite well determined. Phenylethanoid glycosides (acteoside, isoacteoside), iridoid glycosides (aucubin, and aucuboside ester, 6'-O-glucopyranosyl-aucubin, melampyroside, 6'-O-glucopyranosyl melampyroside), simple sugars, fatty acids, organic acids, β-sitosterol were identified. Further study of L. squamaria raw materials is a very promising field including implementation in official medicine.

Objective: Walnut is a medicinal plant that is widely used in traditional medicine. We believe that the study of the medicinal plant material of walnut-fruit in the stage of milky-wax maturity and walnut bark is relevant. We described outward signs and microscopy, the diagnostic features of both whole and grinded raw materials, powder bark of walnut and fruits of walnut in the stage of milky-wax maturity.Methods: Alcohol extraction which was derived from walnut bark is a transparent liquid of brown color and alcohol extraction which was derived walnut fruits in the stage of milky-waxy maturity is a transparent, green-brown liquid with a fragrant smell. We performed thin-layer chromatography for the walnut cortex and identified gallic acid.Results: A method of chromatography-mass spectrometry in alcohol extraction from walnut fruit in the stage of milky-waxy maturity allowed to identify 17 compounds belonging to different classes of biologically active substances. We identified sugars, flavonoids, phenolic compounds of coumarins and organic acids. In alcohol extraction from the walnut bark we identified marker substances.

Objective: The study was carried out with an objective to characterize the possible bioactive phytochemical constituents from fruits of Schisandra chinensis Bail. by liquid chromatography–mass spectrometry analysis.Methods: Plant material was collected from Schisandra chinensis during August–October. The dried plant fruits were extracted with solvents using ethanol 95% extractor. The results of chromatography–MS analysis performed on the instrument Agilent Technologies established the presence of major and minor components. It was conducted a qualitative and quantitative comparison of infusions using software ChemStationE 02.00 and full library of mass spectra NIST 05.

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Objective: Walnut is a medicinal plant that is widely used in traditional medicine. We believe that the study of the medicinal plant material of walnut-fruit in the stage of milky-wax maturity and walnut bark is relevant. We described outward signs and microscopy, the diagnostic features of both whole and grinded raw materials, powder bark of walnut and fruits of walnut in the stage of milky-wax maturity.Methods: Alcohol extraction which was derived from walnut bark is a transparent liquid of brown color and alcohol extraction which was derived walnut fruits in the stage of milky-waxy maturity is a transparent, green-brown liquid with a fragrant smell. We performed thin-layer chromatography for the walnut cortex and identified gallic acid.Results: A method of chromatography-mass spectrometry in alcohol extraction from walnut fruit in the stage of milky-waxy maturity allowed to identify 17 compounds belonging to different classes of biologically active substances. We identified sugars, flavonoids, phenolic compounds of coumarins and organic acids. In alcohol extraction from the walnut bark we identified marker substances.