Anti-inflammatory and antioxidant activities of the Impatiens noli-tangere and Stachys officinalis polyphenolic-rich extracts

Păun, Gabriela; Neagu, Elena; Moroeanu, Veronica; Albu, Camelia; Ursu, Tudor‐Mihai; Zanfirescu, Anca; Negreş, Simona; Chiriţă, Cornel; Radu, Gabriel Lucian

doi:10.1016/j.bjp.2017.10.008

Cited by 39 publications

(35 citation statements)

References 36 publications

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“…[ 29 ] reported the presence of malvidin and peonidine derived in samples of I. noli-tangere . [ 30 ] observed malvidin glucosides in flowers of the species I. textorii Miq., while [ 31 ] identified derivatives of pelargonidine, peonidine, and malvidin in petals of I. balsamina .…”

Section: Resultsmentioning

confidence: 99%

“…No studies were found in the literature regarding the anti-inflammatory activity of I. walleriana . However, [ 29 ] evaluated the anti-inflammatory activity of the ethanolic extract (50:50, v / v ) of dry leaves and stems of the I. noli-tangere species against the inflammatory enzymes lipoxygenase (LOX) and cyclooxygenase (COX-1 and COX-2). The authors stated that the bioactive extracts found are promising sources for the treatment of inflammatory diseases [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

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Chemical Composition and Bioactive Characterisation of Impatiens walleriana

Pires

Pereira

et al. 2021

Molecules

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The attractive colour characteristics of the flowers of the species Impatiens walleriana have been arousing great interest in the food industry, which is looking for potential natural sources of colouring ingredients. In this sense, the present work focused on the chemical and bioactive characterization of pink and orange flowers of I. walleriana. The phenolic compounds were determined by HPLC-DAD-ESI/MS; in addition, different bioactivities (antioxidant, antimicrobial, anti-inflammatory and cytotoxicity) were also analysed. Both samples studied showed significant amounts of phenolic compounds, especially phenolic acids, flavonoids, and anthocyanins, which justifies the excellent performance in the different bioactivities studied. The orange variety, despite having a greater variety of phenolic compounds, showed a total amount of compounds lower than the pink variety. Overall, the flowers of I. walleriana emerge as a promising resource to be explored by the food industry.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Bioactive Characterisation of Impatiens walleriana

Pires

Pereira

et al. 2021

Molecules

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“…Development and use of efficient technologies for the bioactive compound's extraction and concentration represent a current priority. Nowadays, ultrasonic-assisted extraction (UAE) and membrane technology have become the most important and efficient technique for extraction [ 7 , 8 ], separation, and concentration of the phenolic compounds from various plant sources [ 8 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Bioactivity Evaluation ofEryngium planumandCnicus benedictusPolyphenolic-Rich Extracts

Păun

Neagu

Moroeanu

et al. 2019

BioMed Research International

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This study evaluated the biological activities of Eryngium planum and of Cnicus benedictus extracts enriched in polyphenols obtained by nanofiltration. The HPLC-MS analysis showed that E. planum contains mainly flavonoids, especially rutin, while in C. benedictus extracts show the high concentration of the phenolic acids, principally the chlorogenic acid and sinapic acid. Herein, there is the first report of ursolic acid, genistin, and isorhamnetin in E. planum and C. benedictus. C. benedictus polyphenolic-rich extract showed high scavenging activity (IC50=0.0081 mg/mL) comparable to that of standard compound (ascorbic acid) and a higher reducing power (IC50= 0.082 mg/mL), with IC50 having a significantly lower value than IC50 for ascorbic acid. Both extracts were nontoxic to NCTC cell line. Among the investigated herbs, E. planum polyphenolic-rich extract showed the highest inhibitory activities with the IC50 value of 31.3 μg/mL for lipoxygenase and 24.6 μg/mL for hyaluronidase. Both polyphenolic-rich extracts had a higher inhibitory effect on α-amylase and α-glucosidase than that of the acarbose. The synergistic effect of ursolic acid, rutin, chlorogenic acid, rosmarinic acid, genistin, and daidzein identified in polyphenolic-rich extracts could be mainly responsible for the pharmacological potentials of the studied extracts used in managing inflammation and diabetes.

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“…Moreover, the activity of fractions originated from the same plant material also may be divergent, e.g., for two ethanolic fractions isolated from Stachys officinalis extract undergoing the micro- or nanofiltration, the IC 50 values amounted to 38.8 and 1.2 μg/mL, respectively. The IC 50 for quercetin (a reference compound) was 35.2 μg/mL [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonaria obscura and Pulmonaria officinalis Extracts as Mitigators of Peroxynitrite-Induced Oxidative Stress and Cyclooxygenase-2 Inhibitors–In Vitro and In Silico Studies

Krzyżanowska-Kowalczyk

Kowalczyk

Ponczek

et al. 2021

Molecules

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The Pulmonaria species (lungwort) are edible plants and traditional remedies for different disorders of the respiratory system. Our work covers a comparative study on biological actions in human blood plasma and cyclooxygenase-2 (COX-2) -inhibitory properties of plant extracts (i.e., phenolic-rich fractions) originated from aerial parts of P. obscura Dumort. and P. officinalis L. Phytochemical profiling demonstrated the abundance of phenolic acids and their derivatives (over 80% of the isolated fractions). Danshensu conjugates with caffeic acid, i.e., rosmarinic, lithospermic, salvianolic, monardic, shimobashiric and yunnaneic acids were identified as predominant components. The examined extracts (1–100 µg/mL) partly prevented harmful effects of the peroxynitrite-induced oxidative stress in blood plasma (decreased oxidative damage to blood plasma components and improved its non-enzymatic antioxidant capacity). The cellular safety of the extracts was confirmed in experimental models of blood platelets and peripheral blood mononuclear cells. COX-2 inhibitor screening evidently suggested a stronger activity of P. officinalis (IC50 of 13.28 and 7.24 µg/mL, in reaction with synthetic chromogen and physiological substrate (arachidonic acid), respectively). In silico studies on interactions of main components of the Pulmonaria extracts with the COX-2 demonstrated the abilities of ten compounds to bind with the enzyme, including rosmarinic acid, menisdaurin, globoidnan A and salvianolic acid H.

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Anti-inflammatory and antioxidant activities of the Impatiens noli-tangere and Stachys officinalis polyphenolic-rich extracts

Cited by 39 publications

References 36 publications

Chemical Composition and Bioactive Characterisation of Impatiens walleriana

Chemical Composition and Bioactive Characterisation of Impatiens walleriana

Chemical and Bioactivity Evaluation ofEryngium planumandCnicus benedictusPolyphenolic-Rich Extracts

Pulmonaria obscura and Pulmonaria officinalis Extracts as Mitigators of Peroxynitrite-Induced Oxidative Stress and Cyclooxygenase-2 Inhibitors–In Vitro and In Silico Studies

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