Yeast extract elicitation increases vinblastine and vincristine yield in protoplast derived tissues and plantlets in Catharanthus roseus

Maqsood, Mehpara; Mujib, A.

doi:10.1016/j.bjp.2017.05.008

Cited by 43 publications

(14 citation statements)

References 53 publications

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“…Jasmonic acid, which is a lipid-derived plant compound and a plant phytohormone, also acts as an elicitor inducing secondary metabolism of many plants when applied exogenously [10,11]. Complex biological preparations such as yeast extract and microbial cell-wall preparations have often been used as biotic elicitors in in vitro plant cultures [12]. Jasmonic acid is an abiotic elicitor: it is exactly one compound while some biotic elicitors like yeast extract are elicitors where the molecular structure of active compound is not fully known, but there are many studies confirm that they can act as elicitor.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative and Potentially Anti-inflammatory Activity of Phenolics from Lovage Leaves Levisticum officinale Koch Elicited with Jasmonic Acid and Yeast Extract

et al. 2019

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The effect of elicitation with jasmonic acids (JA) and yeast extract (YE) on the production of phenolic compounds as well as the antioxidant and anti-inflammatory properties of phenolic extracts of lovage was evaluated. The analysis of phenolic compounds carried out with the UPLC-MS technique indicated that rutin was the dominant flavonoid, while 5-caffeoylquinic acid was the main component in the phenolic acid fraction in the lovage leaves. The application of 10 µM JA increased the content of most of the identified phenolic compounds. The highest antioxidant activities estimated as free radical scavenging activity against ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and reducing power were determined for the sample elicited with 10 µM JA, while this value determined as iron chelating ability was the highest for the 0.1% YE-elicited lovage. The 0.1% and 1% YE elicitation also caused significant elevation of the lipoxygenase (LOX) inhibition ability, while all the concentrations of the tested elicitors significantly improved the ability to inhibit cyclooxygenase 2 (COX2) (best results were detected for the 10 µM JA and 0.1% YE2 sample). Thus, 0.1% yeast extract and 10 µM jasmonic acid proved to be most effective in elevation of the biological activity of lovage.

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Section: Introductionmentioning

confidence: 99%

Antioxidative and Potentially Anti-inflammatory Activity of Phenolics from Lovage Leaves Levisticum officinale Koch Elicited with Jasmonic Acid and Yeast Extract

et al. 2019

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“…There are reports on the isolation of fungal endophytes from C. roseus but there are only a few reports on the isolation of endophytic bacteria and optimization of the components of nutrient agar medium. Yeast extract has been reported as biotic elicitor; it has been recognized as a signaling element in enriching indole alkaloids in various protoplastderived tissues and plantlets of C. roseus [34]. But yeast extract is mainly known to provide carbon and nitrogen to the bacteria, and such elicitation activities for the production of useful secondary metabolites has not been studied yet in endophytes.…”

Section: Discussionmentioning

confidence: 99%

Endophytic bacteria of Catharanthus roseus as an alternative source of Vindoline and application of response surface methodology to enhance its production

Anjum

Chandra

2019

ARCH BIOL SCI BELGRA

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The requirement for novel, cost-effective pharmaceutical compounds is growing. We screened endophytic bacteria of Catharanthus roseus for the production of vinca alkaloids. Vindoline-producing endophytic bacteria was identified as Microbacterium sp. Vindoline was purified and characterized using column chromatography, TLC, HPLC and electrospray ionization mass spectrometry. The subsequent aim of this study was to design a cost-efficient media that can maximize vindoline production from Microbacterium sp. Initial optimization of the nutritional requirement and of the process parameters were carried out by monothetic analysis. Key factors obtained were optimized by the central composite design of response surface methodology. This model was also validated by repeating the experiment under the optimized conditions, which resulted in maximum production of 82 μg/L (predicted response was 76.21 μg/L). Reliability of the experiments was confirmed by ANOVA analysis, regression coefficient, prediction vs actual chart and a 3D response plot, which determined the fit of the model. This study should serve as a reference point for the use of statistical techniques in bacterial systems for production of bioactive, anticancer compounds by plant endophytes.

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“…Other study also reported that the addition of fungus elicitor of Aspergillus flavus lead to a significant stimulation of cell growth and increase in both vinblastine and vincristine production (Tonk et al, 2016). Recent research reported on the positive effect of yeast extract supplementation to culture medium on increasing the vinblastine and vincristine when added in concentration as low as 1.5g/L in suspension culture of C. roseus (Maqsood and Abdul, 2017).…”

Section: Production Of Anticancer Compounds Of C Roseus In Submergedmentioning

confidence: 93%

Anticancer Molecules from Catharanthus roseus

Taher

Agouillal

et al. 2019

Indonesian J. Pharm.

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Catharanthus roseus is an important medicinal plant found in various parts of the world and the bioactive compound has been extracted and used as anticancer agent to treat the cancer over decades. However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. Toxic pollution occurs when synthetic chemicals are discharged or natural chemicals accumulate to toxic levels in the environment, causing reductions in wildlife numbers, degrading ecosystem functions and threatening human health. This review covers the extraction and phytochemical obtained leading to chemical compounds related to anti-cancer property of C. roseus. Additionally, recent advances of using biological cell cultures were also addressed. Thus, this work can be used for further investigation of C. roseus to be undertaken in future for its anticancer property further development and efficient production in drug industry.

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Yeast extract elicitation increases vinblastine and vincristine yield in protoplast derived tissues and plantlets in Catharanthus roseus

Cited by 43 publications

References 53 publications

Antioxidative and Potentially Anti-inflammatory Activity of Phenolics from Lovage Leaves Levisticum officinale Koch Elicited with Jasmonic Acid and Yeast Extract

Antioxidative and Potentially Anti-inflammatory Activity of Phenolics from Lovage Leaves Levisticum officinale Koch Elicited with Jasmonic Acid and Yeast Extract

Endophytic bacteria of Catharanthus roseus as an alternative source of Vindoline and application of response surface methodology to enhance its production

Anticancer Molecules from Catharanthus roseus

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