Pharmacological potential of Maytenus species and isolated constituents, especially tingenone, for treatment of painful inflammatory diseases

Veloso, Clarice C.; Soares, Gutemberg; Perez, Andréa C.; Rodrigues, Vanessa Gregório; Silva, Fernando César

doi:10.1016/j.bjp.2017.02.006

Cited by 35 publications

(15 citation statements)

References 83 publications

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“…32 The opening of a potassium channel present in the membrane of vascular muscle cells causes an increase in ion output, from the intracellular medium into the extracellular medium, causing cell membrane hyperpolarization and then a blockade of voltagedependent Ca 2+ channels and a consequent decrease in the input of Ca 2+ ions into the intracellular medium, causing vascular relaxation. 32,33 Conversely, the closing of potassium channels causes a state of depolarization, opening of voltage-dependent Ca 2+ channels, increase in intracellular Ca 2+ and vasoconstriction. 32 This mechanism of smooth-muscle relaxation and contraction differs regarding the PHE mechanism of action, which directly stimulates the α-adrenergic receptors of the G protein, acting via phospholipase C, increasing the levels of IP3, and resulting in the release of intracellular Ca 2+ , causing muscular contraction.…”

Section: Discussionmentioning

confidence: 99%

Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats

Brozzo

Ferreira

Gonçalves

et al. 2019

International Journal of Cardiovascular Sciences

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Background: Curcuma longa has biological effects. Its cardiovascular activities are yet to be scientifically studied.Objectives: To investigate the vasorelaxant effects of the aqueous extract of Curcuma longa (AECL).Methods: Aortic annuli of normotensive rats, with or without endothelium, were set up in a data storage system with nutrient solution in recipients, with scientifically recommended temperature, aeration and tension. Over contraction by Phenylephrine, the AECL (1, 3, 10, 30, 100, 300 and 1000 μg/mL) was incubated before and after incubation with atropine or L-name or indomethacin. An AECL concentration-response curve was also built over contractions caused by elevation of extracellular K + . Data were significant when p < 0.05, with GraphPad Prism 6.0 software resolutions. Results:The AECL induced 100% vasorelaxation also in the endothelium-free annuli. The part of the endotheliumdependent effect had EC 50 = 4.32 ± 0.05 μg/mL. With inhibition of NO production, the EC 50 increased to 126.50 ± 2.35 μg/mL; after inhibition of prostacyclin production, to 124.6 ± 0.05 μg/mL; and after muscarinic blockade, to 437.10 ± 0.2 μg/mL. Opening of K + channels (relaxation of 56.98%) and VOCC blockade (relaxation of 31.56%) were evident. Conclusion:AECL induced significant vasorelaxation, being more significant in the presence of endothelium. The muscarinic pathway seems to be the main one involved in this effect, followed by the NO production and prostacyclin pathways. The activity in K + channels by AECL was more significant than its VOCC blockade. The use of other models and tools to study action mechanisms will be important and elucidating.

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Section: Discussionmentioning

confidence: 99%

Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats

Brozzo

Ferreira

Gonçalves

et al. 2019

International Journal of Cardiovascular Sciences

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“…(bark, leaves, root). 30 The fluoxetine is a drug of the Selective Inhibitors of Serotonin Recaption family, whose site of action its located at the Synaptic cleft producing an increased and prolonged serotonergic transmission by stimulating many postsynaptic receptors. 31 Then, the antidepressant effect observed could be due to secondary metabolites present in the Maytenus macrocarpa's leaves, of which the most abundant are terpenes, among them the sesquiterpenes and terpenoids such as lupeol, friedeline and epifriedelinol, 32 which have been identified with antioxidant, anti-inflammatory, antinociceptive and antitumor properties, which will result in a neuroprotection effect of the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant and Antipsychotic-like Activity of the Ethanolic Extract of the Leaves of Maytenus macrocarpa

Lucia¹,

Jesus²,

Carolina³

et al. 2018

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Introduction: Maytenus macrocarpa (Chuchuhuasi) is an Amazonian Peruvian traditional plant, traditionally used as anti-inflammatory, antipyretic, antihemorrhagic and antidiarrheic agent. Also, chuchuhuasi is known as a master plant, attributing to it properties in the central nervous system. In addition, depression is a disorder of the mood that cause disability to millions of people around the world. For this reason, the aim of this study was to determinate the antidepressant and antipsychotic-like activity of the ethanolic extract of Maytenus macrocarpa. Methods: It was used the ethanolic extract of the leaves of Maytenus macrocarpa (EELMM) in female mice at the experimental model of the Forced Swim Test described by Porsolt. As control, it was used distillate water, fluoxetine and haloperidol. Results: The immobility time of the groups of EELMM has a mean of 38.26 ± 21.57, 84.32 ± 26.68 and 32.17 ± 25.55 for the doses of 750, 1000 and 1250 mg/Kg respectively; and the immobility time had a median of 7. 5 [4.07 -20.3] and 20.93 ± [17.63 -23.75] for the doses of 500 mg/Kg and 1500 mg/Kg. It was seen a positive dose-response between the dose of 500 to 1000 mg/Kg (Pearson correlation of r=0.8339 and R=0.6954) and a negative dose-response between the dose of 1000 to 1500 mg/Kg. (Pearson correlation of r= -0.7590 and R= 0.5760). Conclusion: It was demonstrated the antidepressant-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa with a dose of 500 mg/kg and an antipsychotic-like activity with a dose of 1000 mg/kg.

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“…Estas diferencias de medias (DM) de aproximadamente 1,3 cm son bastante parecidas a las encontradas en estudios con otras plantas medicinales como el Camellia sinensis (32) -té verde-(DM: 3,75±4,63) y Artemisia annua (33) (DM: 2,6±3,84), pero diferentes a otras especies prometedoras como Sambucus ebulus (34) (DM: 0,77±0,58). El efecto analgésico observado a través de los resultados puede ser justificado por la presencia de algunos fitoconstituyentes como alcaloides: mayteína y 6-benzoil-6-deacetylmayteina, los cuales podrían estar inhibiendo la proteincinasa, una proteína que tiene participación en los mecanismos del dolor (24,25) . Se encontró también una disminución del puntaje referente a la capacidad funcional, teniendo un mejor desempeño la dosis de 80 mg/kg p.c.…”

Section: Discussionunclassified

“…Así mismo, se ha encontrado que los extractos derivados de esta especie tienen efectos antiinflamatorios, probablemente debido a sus componentes, entre los que destacan los terpenos y alcaloides como: 6-benzoil-6-deacetilmayteína, catequintaninos, maytansina, mayteína, maytenina (23,24). Estos compuestos inhiben los efectos de la prostaglandina E2 (PGE2) en macrófagos estimulados con endotoxinas bacterianas, y reducen la producción de citoquinas proinflamatorias como TNF-α, IL-6 y IL-1β (25) .…”

Section: Introductionunclassified

Efecto de Maytenus krukovii "Chuchuhuasi" en el tratamiento de osteoartrosis leve-moderada. Ensayo clínico aleatorizado doble-ciego, controlado con placebo.

Mendocilla-Risco¹,

Villar-López²,

Villar-Lopez³

et al. 2017

Rev. per. med. integr.

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21REV PERU MED INTEGRATIVA.2017;2(1):21-9. ResumenObjetivo. Evaluar la seguridad y eficacia de Maytenus krukovii "chuchuhuasi" a diferentes dosis, en pacientes con osteoartrosis leve-moderada. Materiales y métodos. Ensayo clínico aleatorizado, doble ciego. Se incluyeron a 50 pacientes con osteoartrosis leve-moderada (clasificación de KellgrenLawrence) por cuatro semanas; distribuidos aleatoriamente en tres grupos: I (40 mg/kg/día de M. Krukovii); II (80 mg/kg/día de M. Krukovii) y III (15 g/día de Daucus carota como placebo). Se determinó en sangre: alaninoaminotransferasa (ALT), fosfatasa alcalina (FA), depuración de creatinina, hematocrito, tiempo de protrombina, velocidad de sedimentación y recuento leucocitario. Se evaluó la función, dolor y recorrido articular mediante el test de WOMAC antes y después de la intervención. Resultados. En el grupo II se encontró una disminución estadísticamente significativa de los valores de ALT, tiempo de protrombina y velocidad de sedimentación. El tiempo de protrombina (p=0,012) y la velocidad de sedimentación entre el grupo II y el grupo placebo fueron diferentes (p=0,003). El dolor referido fue estadísticamente distinto entre ambos grupos de estudio en comparación con el placebo (p=0,001; diferencia de medias: 1,3±0,89 en ambos casos). En el caso de la capacidad funcional, solo se encontró diferencia significativa entre el grupo II y el placebo (p=0,001, diferencia de medias: 2,1±1,0). El recorrido articular de rodilla fue diferente entre el grupo I y el grupo III (p=0,004). Conclusión. El uso de M. krukovii "chuchuhuasi" a dosis de 40 y 80 mg/kg p.c. por día, mostró disminuir el dolor referido y mejorar la capacidad funcional en pacientes con diagnóstico de osteoartrosis leve a moderada. Palabras clave: Maytenus; Osteoartritis; Ensayo Clínico; Tolerancia a medicamentos (Fuente DeCS)Safety and efficacy of Maytenus krukovii "Chuchuhuasi" decoction in mild to moderate osteoarthritis. A 4-week randomized double-blind placebo-controlled clinical trial Abstract Objective.To evaluate security and efficacy of Maytenus krukovii "chuchuhuasi" in different doses in patients who had mild-moderate osteoarthritis. Materials and Methods. Randomized Clinical Trial. Fifty patients with mild-moderate osteoarthritis (Kellgren-Lawrence classification) were included in a 4-week follow-up. They were distributed in three groups: I (40mg/kg/day of M. Krukovii); II (80 mg/kg/day of M. Krukovii) y III (15 g/day of Daucus carota, which acted like placebo). Alanine aminotransferase (ALT), alkaline phosphatase, creatinine depuration, hematocrit, prothrombin time, velocity of sedimentation and leukocyte count (WBC) were measured. The articular function, pain and join path were evaluated using WOMAC questionnaire before and after intervention. Results. A significate diminution of ALT, prothrombin time and velocity of sedimentation values (before and after intervention) was found in group II. Prothrombin time (p=0.012) and velocity of sedimentation (p=0.003) were statically different between group II ...

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Pharmacological potential of Maytenus species and isolated constituents, especially tingenone, for treatment of painful inflammatory diseases

Cited by 35 publications

References 83 publications

Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats

Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats

Antidepressant and Antipsychotic-like Activity of the Ethanolic Extract of the Leaves of Maytenus macrocarpa

Efecto de Maytenus krukovii "Chuchuhuasi" en el tratamiento de osteoartrosis leve-moderada. Ensayo clínico aleatorizado doble-ciego, controlado con placebo.

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