Comparative study of the hypocholesterolemic, antidiabetic effects of four agro-waste Citrus peels cultivars and their HPLC standardization

Fayek, Nesrin M.; El-Shazly, Amani H.; Abdel-Monem, Azza R.; Moussa, Mohamed Y.; Abdelwahab, Sherif; El-Tanbouly, Nebal D.

doi:10.1016/j.bjp.2017.01.010

Cited by 27 publications

(23 citation statements)

References 34 publications

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“…Literature showed that citrus genus was able to counteract the effect of high cholesterol level (Favela-Hernández et al, 2016). Recently, the hypocholesterolemic effects of mandarin peels' aqueous and n-hexane extracts was demonstrated (Fayek et al, 2017). The results showed that these extracts decrease the cholesterol level by 59.3% and 56.8%, respectively.…”

Section: Antibacterial Potentialmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Antibacterial Potentialmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…Indrianingsih et al (2015) have found that L. nobilis methanolic extract at the concentration of 0.2 mg/mL inhibited 47.26% α-glucosidase, which is in agreement with the results obtained in this study for the cultivated L. nobilis. Fayek et al (2017) investigated the antidiabetic potency of different Citrus peel extracts and showed that mandarin peels decreased the glucose level in rats. Oboh and Ademosun (2011) found that α-glucosidase inhibitory effect of the Shaddock (Citrus maxima) peel acetonic extract achieved 89.05% at the tested concentration of 0.32 mg/mL.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

In vitro evaluation of antioxidant, antineurodegenerative and antidiabetic activities of Ocimum basilicum L., Laurus nobilis L. leaves and Citrus reticulata Blanco peel extracts

Duletić-Laušević¹,

Oalđe²,

Alimpić-Aradski³

2019

Lekovite sirovine

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Ocimum basilicum (sweet basil) and Laurus nobilis (bay leaves or laurel) have been used in traditional medicine for centuries, and also extensively employed as spices for adding aroma and flavor to various food products. Citrus reticulata (mandarin) is mainly used in food industry for juice production, while its peel as main byproduct contains high concentration of valuable substances. The samples were collected in Lastva Grbaljska (Montenegrin coast) and purchased from the market. Since the oxidative stress results in development of numerous diseases, among them neurodegeneration and diabetes, the antioxidant activity, antineurodegenerative and antidiabetic activities were analyzed, aiming to compare potential of plants cultivated under natural conditions and commercially purchased from the market, as well as to compare the effect of different solvents applied in the extraction process. Water, methanol and acetone extracts of leaves and peel were tested by DPPH and total reducing power (TRP) methods for determination of antioxidant activity, and by acetylcholinesterase (AChE) and αglucosidase inhibition assays for analyzing the other activities. Total phenolic (TPC) and flavonoid (TFC) contents were also determined. The acetonic extract of L. nobilis from Lastva showed the highest TPC, DPPH, TRP, and α-glucosidase inhibition, while water extract of commercial L. nobilis exhibited the highest AChE inhibition. The leaves of L. nobilis are demonstrated to be promising antioxidant, antineurodegenerative and antidiabetic agent.

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“…Of note, synephrine, an alkaloid from citrus peels has been shown to reduce cholesterol synthesis in liver (Fayek et al, 2017). Further, the citrus fruit peel extracts contain lavonoids, polyphenols, alkaloids, glycosides, steroids, carotenoids, and terpenoids (Pallavi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Though, bioactive principles from citrus fruits are known to exhibit anti-hyperglycemic, anti-obesity, and hypercholesterolemic effects (Kurowska and Manthey, 2004;Ono et al, 2011), it is worth considering the unexploited and wasted citrus fruit peels to discover their health bene its. In this line, so far, citrus fruit peels have been shown to display signi icant antioxidant, anti-in lammatory, anti-proliferative, and cancer prevention activity (Fayek et al, 2017;Pallavi et al, 2017). However, there are no systematic and comparative studies on anti-hyperlipidemic effects of citrus fruit peels.…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperlipidemic effects of citrus fruit peel extracts against high fat diet-induced hyperlipidemia in rats

Pallavi

Siddesha

et al. 2021

ijrps

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The effects of extracts of orange, , lime, citron and sour orange fruit peels (250 and 500 mg kg-1, i.p) were tested in high fat diet-fed rats. The extracts of lime and sour orange peels (250 and 500 mg kg-1, i.p) showed potent effects, as evident by the decreases in total cholesterol (TC), triglycerides (TG), LDL-C, and VLDL-C, in addition to the increases in HDL-C levels. Besides, lime and sour orange peels (250 and 500 mg kg-1) extract significantly decreased LDL-C/HDL-C ratio, while lime, sour orange and peel extracts markedly decreased index. Remarkably, lime peel extract followed by sour orange and orange at 500 mg kg-1 improved hepatic architecture to near normal with less deposition of fat globules and fewer. Altogether, lime and sour orange peel extracts were found to be effective against parameters such as TC, TG, LDL-C, VLDL-C, and TC/HDL-C and LDL-C/HDL-C ratios, and index, in addition to the increased levels of HDL-C. Thus, lime and sour orange peel extracts could be natural supplement in the management of and associated diseases.

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Comparative study of the hypocholesterolemic, antidiabetic effects of four agro-waste Citrus peels cultivars and their HPLC standardization

Cited by 27 publications

References 34 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

In vitro evaluation of antioxidant, antineurodegenerative and antidiabetic activities of Ocimum basilicum L., Laurus nobilis L. leaves and Citrus reticulata Blanco peel extracts

Anti-hyperlipidemic effects of citrus fruit peel extracts against high fat diet-induced hyperlipidemia in rats

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