Schinus terebinthifolius : phenolic constituents and in vitro antioxidant, antiproliferative and in vivo anti-inflammatory activities

Silva, Marciane M. da; Iriguchi, Edna K K; Kassuya, Cândida Aparecida Leite; Vieira, Maria do Carmo; Foglio, Mary Ann; Carvalho, João Ernesto de; Ruiz, Ana Lúcia Tasca Góis; Souza, Kely de Picoli; Formagio, Anelise Samara Nazari

doi:10.1016/j.bjp.2016.12.007

Cited by 30 publications

(13 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results indicated that STF exhibits neuroprotective effects against oxidative stress, which is correlated with the previous studies. Silva et al [57] demonstrated in vitro antioxidant, antiproliferative, and in vivo anti-inflammatory activities of Schinus terebinthifolius due to the presence of phenolic constituents. However, Dumitru et al [31] already reported that Schinus polygamus (Cav.)…”

Section: Resultsmentioning

confidence: 99%

Schinus terebinthifoliusEssential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model

Todirascu-Ciornea

El-Nashar

Mostafa

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Schinus terebinthifolius is a plant well recognized for its therapeutic profile such as anti-inflammatory and antitumor activities, promoting antibacterial activity and antioxidant and antidiabetic properties. This study aimed at examining whether Schinus terebinthifolius memory-enhancing activities are mediated by cholinergic and brain antioxidant systems in a scopolamine zebrafish model. Schinus terebinthifolius essential oil (10, 25, and 50 μL/L) was delivered to zebrafish by immersion in water for 8 days. Memory deficits were induced by scopolamine (100 μM) administration. Zebrafish were divided into seven groups (n = 15/group): vehicle group, scopolamine (100 μM) group, Schinus terebinthifolius essential oil groups (STF; 10, 25, and 50 μL/L), the imipramine group (IMP; 20 mg/L, as the positive control in the NTT test), and the donepezil group (DP; 10 mg/L, as the positive control in the Y-maze test). Memory status was estimated by the novel tank diving test (NTT) and the Y-maze test and finally was validated by comparison with imipramine (20 mg/L) and donepezil (10 mg/L). Gas chromatography-mass spectrometry (GC-MS) was used to detect oil compounds. Brain levels of acetylcholinesterase (AChE) and antioxidant enzymes were measured. After being exposed to Schinus terebinthifolius essential oil, the scopolamine zebrafish exhibited an improvement of memory processes in the NTT and Y-maze tests. The essential oil attenuated the elevated level of AChE and brain oxidative stress. Schinus terebinthifolius essential oil was found to support memory formation through the inhibition of the AChE activity and decreasing oxidative stress in the scopolamine-treated zebrafish brains.

show abstract

Section: Resultsmentioning

confidence: 99%

Schinus terebinthifoliusEssential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model

Todirascu-Ciornea

El-Nashar

Mostafa

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In traditional medicine, this plant is used to treat skin wounds and ulcers, tumors, diarrhea, arthritis as well as urinary and respiratory tract infections (Brandão et al, 2006). Various pharmacological activities have been described for this plant, including antimicrobial (Silva et al, 2017a), antiulcerogenic (Carlini et al, 2010), anticancer (Silva et al, 2017b), antihistamine (Nunes-Neto et al, 2017), antihypertensive (Glória et al, 2017), antihyperalgesic (Piccinelli et al, 2015), wound healing (Estevão et al, 2017), anti-inflammatory (Silva et al, 2017b) and antioxidant (Rocha et al, 2017) activities in different models.…”

Section: Introductionmentioning

confidence: 99%

Microbiological quality, chemical profile as well as antioxidant and antidiabetic activities of Schinus terebinthifolius Raddi

Rocha

Boleti

Vieira

et al. 2019

Comparative Biochemistry and Physiology Part C: Toxicology &

View full text Add to dashboard Cite

Schinus terebinthifolius Raddi, commonly known as Brazilian peppertree, is a plant species widely used in Brazilian traditional medicine for various purposes. The objective of this study was to assess the microbiological quality, safety, chemical profile as well as antioxidant and antidiabetic potentials of different parts of S. terebinthifolius. Microbiological analysis of the methanolic extracts of the roots (MESR), stem bark (MESB) and leaves (MESL) of S. terebinthifolius showed no microbial growth. The concentrations of phenolic compounds, phenolic acids and flavonoids were determined by spectrophotometry. The phenolic compounds of the MESL were identified by liquid chromatography coupled to a diode array detector and mass spectrometer (LC-DAD-MS). The antioxidant activities of the extracts were analyzed by 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl radical (DPPH%), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical (ABTS% +), fluorescence recovery after photobleaching (FRAP), reducing power, β-carotene bleaching and malondialdehyde (MDA) assays in human erythrocytes. The antidiabetic properties of the extracts were demonstrated in vitro by their inhibition of the α-glucosidase enzyme and their anti-glycation activity via fructose and glyoxal. After showing no acute toxicity in vivo, MESL was able to lower postprandial glycemia after glucose overload in normoglycemic mice as well as the water and feed intake, liver weight, glycemia and serum levels of glycated hemoglobin, aspartate transaminase (AST) and alanine transaminase (ALT) in diabetic mice. Overall, S. terebinthifolius extracts showed microbiological safety along with antioxidant and antidiabetic activities, likely mediated by its chemical constituents, such as gallic acid, gallotannins and glycosylated flavonols.

show abstract

“…The antioxidant [ 19 , 20 , 21 , 22 , 23 ] and antimicrobial [ 21 , 23 , 24 , 25 , 26 ] activities of different parts of S. terebinthifolius have been described using different pharmacological models. However, only the endophytic fungi of S. terebinthifolius leaves [ 24 , 27 , 28 ] have been identified.…”

Section: Introductionmentioning

confidence: 99%

Diversity, Chemical Constituents and Biological Activities of Endophytic Fungi Isolated from Schinus terebinthifolius Raddi

et al. 2020

View full text Add to dashboard Cite

Schinus terebinthifolius Raddi is a medicinal plant widely used for the treatment of various diseases. The secondary metabolites responsible for the pharmacological properties can be produced directly by the plant or by endophytic fungi. The objective of this study was to evaluate the diversity of endophytic fungi of different parts of S. terebinthifolius and to identify chemical compounds produced by endophytes and their antioxidant and antibacterial activities. For this, fruits, stem bark and roots were dried, ground and placed in fungal growth medium. The selected endophytes were grown and subjected to extraction with ethyl acetate. DPPH, FRAP, β-carotene bleaching and antimicrobial assays were performed. The phylogenetic tree was elaborated, encompassing 15 different species. The fungal extracts showed hydroxybenzoic acids and 1-dodecanol as predominant compounds. All fungal extracts exhibited antioxidant activity. The fungal extracts exhibited bactericidal and bacteriostatic activities against Gram-positive and Gram-negative bacterial ATCC strains and against methicillin-resistant nosocomial bacteria. Among the 10 endophytic fungi evaluated, the extract of the fungus Ochrocladosporium elatum showed higher phenolic content and exhibited higher antioxidant and antibacterial activities in all tests. Together, the results increase the known diversity of S. terebinthifolius endophytic fungi, secondary metabolites produced and their antioxidant and antibacterial activities.

show abstract

Schinus terebinthifolius : phenolic constituents and in vitro antioxidant, antiproliferative and in vivo anti-inflammatory activities

Cited by 30 publications

References 40 publications

Schinus terebinthifoliusEssential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model

Schinus terebinthifoliusEssential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model

Microbiological quality, chemical profile as well as antioxidant and antidiabetic activities of Schinus terebinthifolius Raddi

Diversity, Chemical Constituents and Biological Activities of Endophytic Fungi Isolated from Schinus terebinthifolius Raddi

Contact Info

Product

Resources

About