Maytenus distichophylla and Salacia crassifolia : source of products with potential acetylcholinesterase inhibition

Ferreira, Fernanda Lopes; Rodrigues, Vanessa Gregório; Silva, Fernando C.; Matildes, Bibiane Lindsay Guimarães; Takahashi, Jacqueline A.; Silva, Grácia D. F.; Duarte, Lucienir Pains; Oliveira, Djalma Menezes de; Filho, Sidney Augusto Vieira

doi:10.1016/j.bjp.2016.12.006

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…Acetylcholinesterase inhibition potential by extracts obtained from leaves of Maytenus distichophylla and Salacia crassifolia contained triterpenes was evaluated by Ferreira et al [ 29 ]. The in vitro anti-acetylcholinesterase activity of extracts and their constituents was determined using a 96-well microtiter plate following the Ellman’s method.…”

Section: Determination Of Anti-neurodegenerative Disease Activity Of ...mentioning

confidence: 99%

“…The in vitro anti-acetylcholinesterase activity of extracts and their constituents was determined using a 96-well microtiter plate following the Ellman’s method. For both investigated chloroform extracts, 3β,24-dihydroxyfriedelane, 3-oxo-28,29-dihydroxyfriedelane and 3 β-palmityloxy-urs-12-ene acetylcholinesterase inhibitory activities were observed [ 29 ]. The results showed that the crude extracts and some isolated terpenes have an acetylcholinesterase inhibition property similar to that presented by physostigmine and can be considered for further investigations.…”

Section: Determination Of Anti-neurodegenerative Disease Activity Of ...mentioning

confidence: 99%

“…The accumulation of aggregated proteins at neurons has been correlated with Alzheimer’s disease patients, who show the presence of amyloid fibrils in the brain, which indicates the relationship between amyloid fibrils and the disease [ 19 ]. The accumulation of this toxic peptide leads to the deposition of β-amyloid into plaques and is thought to drive a pathologic cascade, which culminates in neuronal death [ 29 ]. These fibrils accumulate in the brain cells and central nervous system of Alzheimer’s disease patients and contribute to the symptoms of dementia.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Anti-Alzheimer’s Disease Activity of Selected Plant Ingredients

Tuzimski

Petruczynik

2022

Molecules

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Neurodegenerative diseases, among which one of the more common is Alzheimer’s disease, are the one of the biggest global public health challenges facing our generation because of the increasing elderly population in most countries. With the growing burden of these diseases, it is essential to discover and develop new treatment options capable of preventing and treating them. Neurodegenerative diseases, among which one of the most common is Alzheimer’s disease, are a multifactorial disease and therefore demand multiple therapeutic approaches. One of the most important therapeutic strategies is controlling the level of acetylcholine—a neurotransmitter in cholinergic synapses—by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. However, these drugs can cause some adverse side effects, such as hepatotoxicity and gastrointestinal disorder. Thus, the search for new, more effective drugs is very important. In the last few years, different active constituents from plants have been tested as potential drugs in neurodegenerative disease therapy. The availability, lower price and less toxic effects of herbal medicines compared with synthetic agents make them a simple and excellent choice in the treatment of neurodegenerative diseases. The empirical approach to discovering new drugs from the systematic screening of plant extracts or plant-derived compounds is still an important strategy when it comes to finding new biologically active substances. The aim of this review is to identify new, safe and effective compounds that are potential candidates for further in vivo and clinical tests from which more effective drugs for the treatment of Alzheimer’s disease could be selected. We reviewed the methods used to determine anti-Alzheimer’s disease activity. Here, we have discussed the relevance of plant-derived compounds with in vitro activity. Various plants and phytochemical compounds have shown different activity that could be beneficial in the treatment of Alzheimer’s disorders. Most often, medicinal plants and their active components have been investigated as acetylcholinesterase and/or butyrylcholinesterase activity inhibitors, modifiers of β-amyloid processing and antioxidant agents. This study also aims to highlight species with assessed efficacy, usable plant parts and the most active plant components in order to identify species and compounds of interest for further study. Future research directions are suggested and recommendations made to expand the use of medicinal plants, their formulations and plant-derived active compounds to prevent, mitigate and treat Alzheimer’s disease.

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Section: Determination Of Anti-neurodegenerative Disease Activity Of ...mentioning

confidence: 99%

Section: Determination Of Anti-neurodegenerative Disease Activity Of ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of Anti-Alzheimer’s Disease Activity of Selected Plant Ingredients

Tuzimski

Petruczynik

2022

Molecules

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“…It is estimated that this family comprises a total of 1350 species belonging to 96 different genera . Many Celastraceae species present pharmacological activities such as antitumor, anti‐inflammatory, antimicrobial, antioxidant, antiviral, analgesic, and acetylcholinesterase inhibitor …”

Section: Introductionmentioning

confidence: 99%

Chemodiversity of Essential Oils from Nine Species of Celastraceae

Camargo

Duarte

Vidal

et al. 2020

Chemistry & Biodiversity

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Extracts and compounds obtained from several species of Celastraceae family are reported as potential sources of drugs due to their diverse pharmacological properties. Nevertheless, essential oil composition from these species is still little known. This work aimed at the analysis of essential oils obtained from different Brazilian Celastraceae species. A total of seventeen oils were obtained using hydrodistillation process and analyzed by gas chromatography/mass spectrometry (GC/MS). Principal component analysis (PCA) allowed the identification of a chemical composition pattern among the analyzed essential oils. Some compounds were more frequent among Celastraceae species, such as cis‐ and trans‐linalool oxide (14/17 oil samples), nerylacetone (13/17), linalool (11/17), β‐ionone (10/17), α‐ionone (9/17), nerolidol (10/17), decanal (10/17), and dodecanoic acid (10/17). These results contribute to the chemophenetics of Celastraceae species.

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“…The following are available online, Table S1: Pentacyclic triterpenoids isolated from Celastraceae species (2001–2021) [ 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 ,…”

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Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

et al. 2022

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The Celastraceae family comprises about 96 genera and more than 1.350 species, occurring mainly in tropical and subtropical regions of the world. The species of this family stand out as important plant sources of triterpenes, both in terms of abundance and structural diversity. Triterpenoids found in Celastraceae species display mainly lupane, ursane, oleanane, and friedelane skeletons, exhibiting a wide range of biological activities such as antiviral, antimicrobial, analgesic, anti-inflammatory, and cytotoxic against various tumor cell lines. This review aimed to document all triterpenes isolated from different botanical parts of species of the Celastraceae family covering 2001 to 2021. Furthermore, a compilation of their 13C-NMR data was carried out to help characterize compounds in future investigations. A total of 504 pentacyclic triterpenes were compiled and distinguished as 29 aromatic, 50 dimers, 103 friedelanes, 89 lupanes, 102 oleananes, 22 quinonemethides, 88 ursanes and 21 classified as others.

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Maytenus distichophylla and Salacia crassifolia : source of products with potential acetylcholinesterase inhibition

Cited by 8 publications

References 24 publications

Determination of Anti-Alzheimer’s Disease Activity of Selected Plant Ingredients

Determination of Anti-Alzheimer’s Disease Activity of Selected Plant Ingredients

Chemodiversity of Essential Oils from Nine Species of Celastraceae

Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

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