Induction of apoptosis by Moutan Cortex Radicis in human gastric cancer cells through the activation of caspases and the AMPK signaling pathway

Park, Cheol; Han, Min‐Ho; Park, Shin‐Hyung; Hong, Su‐Hyun; Kim, Gi‐Young; Moon, Sung‐Kwon; Kim, Wun-Jae; Choi, Yung Hyun

doi:10.1016/j.bjp.2016.11.003

Cited by 5 publications

(7 citation statements)

References 45 publications

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“…A decrease in fatty acid synthesis occurs when the ACC is suppressed, which promotes apoptosis. The phosphorylation of ACC by AMPK is essential for inhibiting the DNL pathway [74,82–85]. Increased AMPK levels were found to inhibit ACC expression and activity, resulting in a decrease in fatty acid synthesis with no change in FASN protein expression, eventually causing cytotoxicity in SKOV3 human ovarian cancer cells after C93 treatment.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

et al. 2022

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The de novo lipogenesis (DNL) pathway has been identified as a regulator of cancer progression and aggressiveness. Downregulation of key lipogenesis enzymes has been shown to activate apoptosis in cancerous cells. Epigallocatechin gallate (EGCG) inhibits cancer cell proliferation without causing cytotoxicity in healthy cells. The present study aimed to investigate the effects of EGCG on the promotion of apoptosis associated with the DNL pathway inhibition in cancer cells, both in vitro and in vivo. We observed that two colorectal cancer cell lines (HCT116 and HT‐29) had a higher cytotoxic response to EGCG treatment than hepatocellular carcinoma cells, including HepG2 and HuH‐7. EGCG treatment decreased cell viability and increased mitochondrial damage‐triggered apoptosis in both HCT116 and HT‐29 cancer cells. Additionally, we treated mice transplanted with HCT116 cells with 30 or 50 mg·kg−1 EGCG for 7 days to evaluate the apoptotic effects of EGCG treatment in a xenograft mouse model of cancer. We observed a decrease in intracellular fatty acid levels, which suggested that EGCG‐induced apoptosis was associated with a decrease in fatty acid levels in cancer. Suppression of ATP synthesis by EGCG indicated that cell death induction in cancer cells could be mediated by shared components of the DNL and energy metabolism pathways. In addition, EGCG‐induced apoptosis suppressed the expression of the phosphorylation protein kinase B and extracellular signal‐regulated kinase 1/2 signaling proteins in tumors from xenografted mice. Cytotoxic effects in unaffected organs and tissues of the mouse xenograft model were absent upon EGCG treatment.

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Section: Discussionmentioning

confidence: 99%

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

et al. 2022

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“…133 Ethanol extract of Moutan Cortex Radicis was investigated for its apoptotic effect in human gastric cancer AGS cells, associated with caspase-dependent apoptosis dosedependently. 53 Heliopsis longipes extract induced caspasedependent apoptosis against various cancer cell lines of HeLa, K-562, and MCF-7 with IC 50 values reported to be 185.32 ± 2.64, 87.14 ± 1.01, and 134.25 ± 0.25 μg/mL, respectively, for 48 h incubation. 134 Camellia sinensis extract exhibited significant cytotoxic activity against colorectal cancer cell line HT-29 with an IC 50 of 87 µg/mL and showed potent caspase-induced apoptosis.…”

Section: Other Compounds Exhibiting Superior Antineoplastic Effects T...mentioning

confidence: 97%

“…52 Combination of carnosic acid and tamoxifen has reported a significant cytotoxic effect by increased activation of caspase-3 in a dose-dependent manner for 24 h treatment in breast cancer cell lines (MCF-7). 53 Erythrofordin B isolated from the leaves of Vietnamese Erythrophleum fordii Oliver was tested for cytotoxic activity against human leukemia cancer cells (HL-60 and KG). It was reported with IC 50 values ranging from 15.2 ± 1.5 to 42.2 ± 3.6 µM and showed apoptotic activity due to the activation of caspase-3 and caspase-9 in a dose-dependent manner for (0-30 µM) for 48 h treatment.…”

Section: Application Of Terpenoids For Programmed Cell Death Involvin...mentioning

confidence: 99%

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Allani,

Akhilesh,

Tiwari

2024

Cell Biochemistry & Function

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Apoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed cell death, which plays an important role in cancer as a classical mechanism of tumor cell death causing minimal inflammation without causing damage to other cells in the vicinity. Induction of apoptosis by activation of caspases is one of the primary targets for cancer treatment. Over the years, a diverse range of natural, synthetic, and semisynthetic compounds and their derivatives have been investigated for their caspase‐mediated apoptosis‐induced anticancer activities. The review aims to compile the preclinical evidence and highlight the critical mechanistic pathways related to caspase‐induced cell apoptosis in cancer treatment. The focus is placed on the key components of the mechanisms, including their chemical nature, and specific attention is given to phytochemicals derived from natural sources and synthetic and semisynthetic compounds. 180+ compounds from the past two decades with potential as anticancer agents are discussed in this review article. By summarizing the current knowledge and advancements in this field, this review provides a comprehensive overview of potential therapeutic strategies targeting apoptosis in cancer cells. The findings presented herein contribute to the ongoing efforts to combat cancer and stimulate further research into the development of effective and targeted anticancer therapies.

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“…Angelicae Sinensis Radix exerts anti‐inflammatory effects by reducing TNF‐α inflammatory cells 322 . Ligusticum Rhizoma inhibits inflammation and reduces PGE 2 production 323 . Moutan Cortex, Glycyrrhizae Radix, Paeoniae Alba Radix, and Bupleuri Radix suppress proinflammatory cytokines via the NF‐κB signaling pathways 324‐327 .…”

Section: Traditional Chinese Medicine (Tcm)mentioning

confidence: 99%

“…Atractylodis Ovatae Rhizoma induces apoptosis by upregulating ROS 333 . Moutan Cortex exerts proapoptotic effects by increasing Bax/Bcl‐2 expression and decreasing MMP via the formation of apoptosome and cytochrome c , activation of CASP, and the adenosine monophosphate‐activated protein kinase pathway 323 . It also induces apoptosis via activation of CASP‐3/‐8 334 .…”

Section: Traditional Chinese Medicine (Tcm)mentioning

confidence: 99%

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

Hung

Zhang

Tan

et al. 2021

Medicinal Research Reviews

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Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and development of endometriotic cells in ectopic sites can be promoted via multiple pathways, including MAPK/MEK/ERK, PI3K/Akt/mTOR, NF‐κB, Rho/ROCK, reactive oxidative stress, tumor necrosis factor, transforming growth factor‐β, Wnt/β‐catenin, vascular endothelial growth factor, estrogen, and cytokines. The underlying pathophysiological mechanisms include proliferation, apoptosis, autophagy, migration, invasion, fibrosis, angiogenesis, oxidative stress, inflammation, and immune escape. Current medical treatments for EM are mainly hormonal and symptomatic, and thus the development of new, effective, and safe pharmaceuticals targeting specific molecular and signaling pathways is needed. Here, we systematically reviewed the literature focused on pharmaceuticals that specifically target the molecular and signaling pathways involved in the pathophysiology of EM. Potential drug targets, their upstream and downstream molecules with key aberrant signaling, and the regulatory mechanisms promoting the growth and development of endometriotic cells and tissues were discussed. Hormonal pharmaceuticals, including melatonin, exerts proapoptotic via regulating matrix metallopeptidase activity while nonhormonal pharmaceutical sorafenib exerts antiproliferative effect via MAPK/ERK pathway and antiangiogenesis activity via VEGF/VEGFR pathway. N‐acetyl cysteine, curcumin, and ginsenoside exert antioxidant and anti‐inflammatory effects via radical scavenging activity. Natural products have high efficacy with minimal side effects; for example, resveratrol and epigallocatechin gallate have multiple targets and provide synergistic efficacy to resolve the complexity of the pathophysiology of EM, showing promising efficacy in treating EM. Although new medical treatments are currently being developed, more detailed pharmacological studies and large sample size clinical trials are needed to confirm the efficacy and safety of these treatments in the near future.

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Induction of apoptosis by Moutan Cortex Radicis in human gastric cancer cells through the activation of caspases and the AMPK signaling pathway

Cited by 5 publications

References 45 publications

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

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