Leaf venation pattern to recognize austral South American medicinal species of “cow's hoof” ( Bauhinia L., Fabaceae)

Fortunato, Renée H.; Varela, Beatriz; Castro, María Águeda; Nores, Manuel

doi:10.1016/j.bjp.2016.10.007

Cited by 8 publications

(10 citation statements)

References 15 publications

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“…2015; Fortunato et al. 2017). Several studies have suggested new organizations of this large genus, and historical factors have complicated its taxonomy and nomenclature (Wunderlin et al.…”

Section: Introductionmentioning

confidence: 99%

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Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation

Camaforte

Saldanha

Vareda

et al. 2019

Pharmaceutical Biology

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Context: Bauhinia L. species, including Bauhinia holophylla (Bong.) Steud. (Fabaceae), have traditionally been used to treat diabetes. Bauhinia is a complex botanical genus, and the indiscriminate use of the diverse Bauhinia species is reflected in the experimental divergence of their medicinal potential. Objective: The hypoglycaemic and hypolipidaemic effects, molecular mechanism of action and phytochemical properties of an authentic extract of B. holophylla leaves were evaluated. Materials and methods: A phytochemical study of a 70% EtOH extract was performed using FIA-ESI-IT-MS/MS n and HPLC-PAD-ESI-IT-MS. The extract (200 or 400 mg/kg b.w.) was administered for 14 days to streptozotocin-induced diabetic Swiss mice. Glucose tolerance and insulin sensitivity, blood parameters, gene and protein expression, and the in vivo and in vitro inhibition of intestinal glucosidases were assessed. Results: HPLC-PAD-ESI-IT-MS analysis identified flavonoid derivatives of quercetin, myricetin, luteolin and kaempferol. Treatment with 400 mg/kg of the extract reduced blood glucose (269.0 ± 32.4 mg/dL vs. 468.0 ± 32.2 mg/dL for diabetic animals), improved glucose tolerance, decreased cholesterol and triglyceride levels, and increased the mRNA expression of proteins involved in glucogenesis in the liver and muscle, such as PI3-K/Akt, GS, GSK3-β (ser-9), AMPK and Glut4. The activity of intestinal maltase was inhibited in vitro (IC 50 : 43.0 µg/mL for the extract compared to 516.4 µg/mL for acarbose) and in vivo . Discussion and conclusions: Treatment with B. holophylla was associated with a marked hypoglycaemic effect through the stimulation of glycogenesis and inhibition of gluconeogenesis and intestinal glucose absorption, without increasing basal insulinaemia.

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“…2015; Fortunato et al. 2017). Several studies have suggested new organizations of this large genus, and historical factors have complicated its taxonomy and nomenclature (Wunderlin et al.…”

Section: Introductionmentioning

confidence: 99%

“…1999; Fortunato et al. 2017). The correct identification of species is difficult, and inaccuracies can cause misidentification of species, resulting in reduced effectiveness of the extracts (Ferreres et al.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation

Camaforte

Saldanha

Vareda

et al. 2019

Pharmaceutical Biology

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“…Fruits are dehiscent legumes with several flattened, oval, bright, and blackish seeds. It is used as ornamental and the leaves and young stems are consumed in infusions mainly as antidiabetic or hypoglycemic agent [20][21][22][23][24][25]. Anti-inflammatory, diuretic, and analgesic activities have also been reported in this species [26,27].…”

Section: Propagationmentioning

confidence: 99%

Novel Therapeutic Uses of Legume Crops in Southern South America

Fortunato¹,

Baluzzi²,

Diego³

et al. 2019

Legume Crops - Characterization and Breeding for Improved Food Security

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The Argentine flora comprises more than 10,000 species, and many of them have been recorded as having medicinal, antimicrobial, and nutraceutical uses in humans as well as veterinary uses. In this chapter, native species/populations from the north of Argentina have been identified, selected, and characterized using morphological, chemical, and molecular techniques. Bauhinia forficata subsp. pruinosa was found to have anti-inflammatory, antidiabetic, diuretic, and analgesic activity and Senna spectabilis var. spectabilis has been found to have antibacterial, antibiofilm, antifungal, and antioxidant properties. The characterization and conservation of the native germplasm will allow us to propose future protocols of adaptation and technological processes to improve the quality of life in the rural areas and sustainable growth. This process will be achieved through a future integral and rational use that contemplates the conservation of the wild populations and their habitat. Thus, new resources will be generated, and the native flora of the country will gain value, strengthening the regional and territorial development of the agricultural and agroindustrial system. In addition, the domestication practices oriented to an integral management of the crop without extraction of the biological resource from the natural habitat minimize the impact of ecosystem degradation by overexploitation associated with landscape fragmentation.

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“…4,5 According to Soares and co-workers 4 , B. candicans is used synonymously to indicate the subspecies pruinosa of B. forficata L. 4 Additionally, medicinal properties have been reported for B. bauhinioides, B. cheilantha, B. holophylla, B. microstachya, B. rufa and B. ungulate. 6 A comparative study with B. forficata, B. candicans, and B. variegata was performed by Soares and Scarminio who used multivariate analysis and mixture designs to verify the authenticity of the species based on fingerprints obtained by high performance liquid chromatography (HPLC). 4 Through Principal Component Analysis (PCA), species were discriminated into four groups and the authors suggested that B. candicans was different from other species; therefore, it could not be regarded as synonymous of B. forficata as affirmed earlier.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, quick, and low-cost auxiliary tools to assist with the correct identification of these plants are necessary since current taxonomic classifications are not infallible, especially concerning the differentiation between species and/or subspecies that have subtle morphological differences. [5][6][7][8] Taking this into consideration, the aim of the current study was to perform an exploratory analysis of commercial and certified noncommercial samples of plants belonging to the Bauhinia genus. To accomplish this, the fingerprints obtained by spectroscopic and spectrometric methods were analyzed using chemometric tools.…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Bauhinia Species by Spectroscopic and Spectrometric Fingerprints

Pianoski¹,

Turco²,

Soares³

et al. 2020

Rev. Virtual Quim.

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Resumo: Algumas espécies de plantas do gênero Bauhinia são plantas medicinais com relevantes propriedades diuréticas, digestivas, anti-inflamatórias, analgésicas, sendo popularmente usadas no tratamento da hipertensão e do diabetes. As plantas deste gênero são conhecidas como "pata-de-vaca" devido ao formato de suas folhas; essa similaridade morfológica entre espécies e/ou subespécies torna sua diferenciação taxonômica um desafio. Buscando uma ferramenta auxiliar para discriminar espécies de Bauhinia, as impressões digitais espectroscópicas e espectrométricas dos extratos das folhas foram comparadas usando a análise de componentes principais (PCA). As amostras foram diferenciadas de acordo com o tipo (comercial ou não comercial), região de origem e espécie. A análise indicou que existem diferenças de perfil químico entre as amostras comerciais e não comerciais possivelmente originadas pela mistura de diferentes espécies de Bauhinia nas amostras comerciais. Desta forma, a PCA é uma ferramenta auxiliar na autenticação de amostras comerciais e não comerciais, rastreamento de origem e classificação taxonômica. Além disso, a atividade antirradicalar foi estatisticamente superior para amostras não comerciais (p<0,05), sugerindo que essa atividade diminui durante o armazenamento na prateleira. Some species of plants of the genus Bauhinia are medicinal plants with relevant pharmaceutical properties such as diuretic, digestive, anti-inflammatory, analgesic and are popularly used to treat hypertension and diabetes. They are widely known as "cow's foot" ("pata-de-vaca") due to the shape of their leaves; this morphological similarity among species and/or subspecies makes their taxonomic differentiation a challenge. Seeking for an auxiliary tool to discriminate Bauhinia species, spectroscopic and spectrometric fingerprints of extracts of Bauhinia leaves were compared using principal component analysis (PCA). Samples were distinguished according to their type (commercial or non-commercial), geographic origin, and specie. Multivariate data analysis indicated that there are differences between the chemical profile of commercial and non-commercial samples possibly due to the mixture of different species of Bauhinia in commercial samples. Thus, PCA may help to authenticate commercial and non-commercial samples, to trace their origin and indicate taxonomic classification. Additionally, the antiradical activity was statistically higher for non-commercial samples (p<0.05), suggesting that this activity diminishes during shelf storage.

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Leaf venation pattern to recognize austral South American medicinal species of “cow's hoof” ( Bauhinia L., Fabaceae)

Cited by 8 publications

References 15 publications

Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation

Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation

Novel Therapeutic Uses of Legume Crops in Southern South America

Identification and Characterization of Bauhinia Species by Spectroscopic and Spectrometric Fingerprints

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