Heliopsis longipes : anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents

Escobedo-Martínez, Carolina; Guzmán-Gutiérrez, Silvia Laura; Hernández-Méndez, María de los Milagros; Cassani, Julia; Trujillo-Valdivia, Alfonso; Castellanos, Luis Manuel Orozco; Enríquez, Raúl G.

doi:10.1016/j.bjp.2016.09.003

Cited by 11 publications

(8 citation statements)

References 16 publications

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“…The antiarthritic activity of DAC and curcumin was assessed in independent experiments. The Freund’s complete adjuvant (FCA) injection in the footpad of the right rear limb of rats in the control group (vehicle) used in the curcumin experiment caused an edema that reached its maximum volume within the acute phase, that is, the first 3–5 days [27] (Figure 1A). In the following days, the edema showed a sudden increase on day 2 and decreased slowly from day 3 to day 10.…”

Section: Resultsmentioning

confidence: 99%

Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model

et al. 2019

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The present study aims to evaluate the antiarthritic activity of diacetylcurcumin (DAC), a synthetic derivative where the free phenolic groups of curcumin are derivatized by acetylation, thereby conferring greater lipophilicity to the parent molecule and partially overcoming the limited systemic bioavailability of curcumin. Antiarthritic activity was evaluated on a Freund’s complete adjuvant (FCA)-induced murine model of arthritis. Oral administration of DAC (60 and 120 mg/kg) resulted in a significant inhibition of inflammation in the acute and chronic phases, respectively, demonstrating an improved and sustained anti-inflammatory effect, comparable to that of curcumin (150 mg/kg) in the chronic stage at a lower dose. Phenylbutazone (80 mg/kg) was used as a reference drug. The pharmacological consequence of DAC or curcumin treatment is the prevention of secondary lesions commonly associated with this biological model.

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Section: Resultsmentioning

confidence: 99%

Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model

et al. 2019

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“…It has antibacterial activity against Escherichia coli, as well as antifungal and anti-aflatoxigenic activity (Molina-Torres et al 1999, Buitimea-Cantúa et al 2020. The anti-inflammatory, antinociceptive, and anti-arthritic activities of H. longipes have been demonstrated in animal models (Acosta-Madrid et al 2009, Hernández et al O n l i n e f i r s t 2009, Cariño- Cortés et al 2010, Cilia-López et al 2010, Arriaga-Alba et al 2013, Escobedo-Martínez et al 2017, de la Rosa-Lugo et al 2017. It has been demonstrated that its anti-inflammatory and anti-arthritic activities are higher than the reference drug phenylbutazone.…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacology of the Asteraceae family in Mexico

Cilia-López¹,

Cariño-Cortés

Zurita-Salinas

2021

Bot. Sci.

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Background: In Mexico, the Asteraceae are part of traditional knowledge where its members have several uses, but they are particularly remarkable in traditional medicine and are used for different purposes. Questions: What pharmacologically studies have been carried out with Asteraceae species used in Mexican traditional medicine? What pharmacological activities have been tested? What compounds are responsible for the tested activities? Species studied: Asteraceae species used in Mexican traditional medicine pharmacologically tested. Methods: A database including scientific studies on Asteraceae species which studies on pharmacological activity or phytochemical characterization was compiled and analyzed. Results: From 249 reviewed studies only 202 fulfilled the criteria for our analysis. A total of 101 species distributed in 65 genera and 16 tribes were registered. The tribes Heliantheae and Senecioneae were the most studied. Ageratina pichinchensis, Artemisia ludoviciana, Heliopsis longipes, and Heterotheca inuloides were the most studied species. In Mexico, the Asteraceae family is mainly used in the treatment of diseases or symptoms related to the digestive and respiratory systems. In 48 % of the studies some biocidal activity was evaluated but only 21.8 % included phytochemical characterizations. Conclusions: The antimicrobial activity and phytochemical characterizations are the main kind of ethnopharmacological studies for Asteraceae in Mexico. Most of the compounds responsible for the activities have not been identified yet. The uses of Asteraceae in Mexico are similar to other countries emphasizing its cultural importance in the world. Mexican Asteraceae should be prioritized in conservation and bioscreening schemes.

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“…A model of induced arthritis was also successful in the response of the species Heliopsis longipes when its hexane extract rich in espilantol was evaluated in rodents [65].…”

Section: Comparison Between Methods Used For Pharmacological Evaluatimentioning

confidence: 99%

“…Carrageenan-induced paw edema [132] Croton oil-induced ear edema [132] Peritonitis induced by lipopolysaccharide [132] Pleurisy induced by carrageenan [89] Model of induced arthritis [65] Model of induced asthma [50] Induced mucositis [37] Wound healing assay [102] Formalin test (inflammatory phase) [93] Psoriasis treatment (clinical trial) [36] Percentage ( The search for more classic pharmaceutical forms, such as drug solutions, found ethanolic or aqueous extracts, among others, of Smallanthus sonchifolius for direct application as topical use, for example, in ear edema as described by Oliveira et al [88]. Among the assayed extracts, the extract obtained by rinsing the leaves with acetone presented the highest percentage of ear edema inhibition (44 %) when applied in mice induced by croton oil.…”

Section: In Vitromentioning

confidence: 99%

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Lopes

Oliveira²,

Viçosa³

et al. 2020

Planta Med

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Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

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Heliopsis longipes : anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents

Cited by 11 publications

References 16 publications

Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model

Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model

Ethnopharmacology of the Asteraceae family in Mexico

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

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