Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model

Escobedo-Martínez, Carolina; Guzmán-Gutiérrez, Silvia Laura; Carrillo-López, María Isabel; Devezé-Álvarez, Martha Alicia; Trujillo-Valdivia, Alfonso; Meza-Morales, William; Enríquez, Raúl G.

doi:10.3390/molecules24142643

Cited by 6 publications

(5 citation statements)

References 32 publications

(40 reference statements)

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“…65 Oral administration with 150 mg/kg curcumin significantly reduced paw oedema. 55 Instead, Jain et al 58 found that 62.5 mg/kg curcumin has a poor effect on the thickness of ankle joints and tail. Oral gavage and intrathecal treatment with curcumin significantly decreased mechanical allodynia and heat hyperalgesia.…”

Section: Curcumin Effect On Radiographic Scorementioning

confidence: 99%

“…(n = 6) 57,68,69,72,75,78 ; and Balb/c (n = 1) 58 ) or rats (Wistar (n = 1 9) 47,49,51,52,53,54,55,56,60,62,63,64,65,66,67,70,71,82,83 ; Sprague-Dawley (n = 9) 48,50,61,74,76,77,79,80,81 ; Charles Foster (n = 1) 73 and in one study there was no information about the kind of rats 59 ). The induction of RA was performed by injection of complete Freund's adjuvant (CFA) (n = 19), 47,48,49,50,51,52,54,55,63,64,65,66,67,70,73,…”

Section: Study Characteristicsmentioning

confidence: 99%

“…None of the studies provided sample size calculations, and eight studies expressed the number of animals per cages 48,51,61,65,68,78,79,80. Finally, according to OHAT's tier system, 20 studies of the total were classified as tier 147,51,54,57,58,61,63,65,66,68,6 9,70,74,75,76,77,79,80,81,83 and 17 as tier 2 48,49,50,52,53,55,56,59,60,62,64,67,71,72,73,78,82.…”

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confidence: 99%

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Curcumin and rheumatoid arthritis: A systematic review of literature

2021

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Background: Curcumin is a natural polyphenol and the main compound from the rhizome of Turmeric (Curcuma longa) and other Curcuma species. It has been widely used for different medical purposes, such as improvement of pain and inflammatory conditions in various diseases.Purpose: This systematic review was aimed to assess all studies regarding the efficacy of the pure form of curcumin (unformulated curcumin) on rheumatoid arthritis (RA). Methods: The comprehensive search of the literature was done until September 2020 on the MEDLINE, Embase, Scopus and Web of Knowledge databases. Out of 2079 initial records, 51 articles (13 in vitro and 37 animal and one human) were met our inclusion criteria. Results: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family, extracellular signal-regulated protein kinase, activator protein-1 and nuclear factor kappa B are the main mechanisms associated with the anti-inflammatory function of curcumin in RA. The results of the only human study showed that curcumin significantly improved morning stiffness, walking time and joint swelling. Conclusion:In conclusion, curcumin seems to be useful, and it is recommended that more human studies be performed to approve the cellular and animal results and determine the effective and optimal doses of curcumin on RA patients. Review criteria• The MEDLINE database (PubMed), Embase, Scopus, and Thomson Reuters Web of Knowledge were systematically and comprehensively searched until September 2020, using related keywords.• All English written original in vitro, animal, and human studies on the effects of curcumin on RA were included.

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Section: Curcumin Effect On Radiographic Scorementioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Curcumin and rheumatoid arthritis: A systematic review of literature

2021

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“…Benzyl bromide was 98% reagent grade; anhydrous potassium carbonate, dry acetone, BF 3 (Et 2 O) and ethyl ether were purchased from Sigma-Aldrich. Curcumin was obtained from natural source by usual extractive procedures and purified by crystallization [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Non-Cytotoxic Dibenzyl and Difluoroborate Curcuminoid Fluorophores Allow Visualization of Nucleus or Cytoplasm in Bioimaging

et al. 2020

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Curcumin, the most important secondary metabolite isolated from Curcuma longa, is known for its numerous purported therapeutic properties and as a natural dye. Herein, based on curcumin’s intrinsic fluorescence, a search for improved curcumin-based fluorophores was conducted. Within the set of semi-synthetic curcumin derivatives i.e. mono (1), di (2), tri (3), tetra (4) benzylated and dibenzyl-fluoroborate (5), the fluorescence properties of 2 and 5 in solution outstood with a two-fold quantum yield compared to curcumin. Furthermore, all benzylated derivatives showed a favorable minimal cytotoxic activity upon screening at 25 μM against human cancer and non-tumoral COS-7 cell lines, with a reduction of its cytotoxic effect related to the degree of substitution. Fluorophores 2 and 5 are versatile bioimaging tools, as revealed by Confocal Fluorescence Microscopy (CFM), and showed permeation of living cell membranes of astrocytes and astrocytomas. When 2 is excited with a 405- (blue) or 543-nm (green) laser, it is possible to exclusively and intensively visualize the nucleus. However, the fluorescence emission fades as the laser wavelength moves towards the red region. In comparison, 5 allows selective visualization of cytoplasm when a 560-nm laser is used, showing emission in the NIR region, while it is possible to exclusively observe the nucleus at the blue region with a 405-nm laser.

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“…Diacetylcurcumin is a synthetic derivative of curcumin, where the free phenolic groups of curcumin have been derivatized by acetylation to confer greater lipophilicity and partially overcome the limited systemic bioavailability of curcumin [ 9 ]. The diacetylcurcumin manganese complex was a diacetylcurcumin derivative synthesized with Mn (II) as a low molecular weight compound with more potent superoxide radical scavenging activity [ 10 ] ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Diacetylcurcumin Manganese Complex on Rotenone-Induced Oxidative Stress, Mitochondria Dysfunction, and Inflammation in the SH-SY5Y Parkinson’s Disease Cell Model

Pirunkaset,

Boonyarat,

Maneenet

et al. 2024

Molecules

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Diacetylcurcumin manganese complex (DiAc-Cp-Mn) is a diacetylcurcumin (DiAc-Cp) derivative synthesized with Mn (II) to mimic superoxide dismutase (SOD). It exhibited superior reactive oxygen species (ROS) scavenging efficacy, particularly for the superoxide radical. The present study investigated the ROS scavenging activity, neuroprotective effects, and underlying mechanism of action of DiAc-Cp-Mn in a cellular model of Parkinson’s disease. This study utilized rotenone-induced neurotoxicity in SH-SY5Y cells to assess the activities of DiAc-Cp-Mn by measuring cell viability, intracellular ROS, mitochondrial membrane potential (MMP), SOD, and catalase (CAT) activities. The mRNA expression of the nuclear factor erythroid 2 p45-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1), inducible nitric oxide synthase (iNOS), and Interleukin 1β (IL-1β), which are oxidative and inflammatory genes, were also evaluated to clarify the molecular mechanism. The results of the in vitro assays showed that DiAc-Cp-Mn exhibited greater scavenging activity against superoxide radicals, hydrogen peroxide, and hydroxyl radicals compared to DiAc-Cp. In cell-based assays, DiAc-Cp-Mn demonstrated greater neuroprotective effects against rotenone-induced neurotoxicity when compared to its parent compound, DiAc-Cp. DiAc-Cp-Mn maintained MMP levels, reduced intracellular ROS levels, and increased the activities of SOD and CAT by activating the Nrf2-Keap1 signaling pathway. In addition, DiAc-Cp-Mn exerted its anti-inflammatory impact by down-regulating the mRNA expression of iNOS and IL-1β that provoked neuro-inflammation. The current study indicates that DiAc-Cp-Mn protects against rotenone-induced neuronal damage by reducing oxidative stress and inflammation.

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Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund’s Complete Adjuvant-Induced Murine Model

Cited by 6 publications

References 32 publications

Curcumin and rheumatoid arthritis: A systematic review of literature

Curcumin and rheumatoid arthritis: A systematic review of literature

Non-Cytotoxic Dibenzyl and Difluoroborate Curcuminoid Fluorophores Allow Visualization of Nucleus or Cytoplasm in Bioimaging

Effect of Diacetylcurcumin Manganese Complex on Rotenone-Induced Oxidative Stress, Mitochondria Dysfunction, and Inflammation in the SH-SY5Y Parkinson’s Disease Cell Model

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