Pterodon pubescens oil nanoemulsions: physiochemical and microbiological characterization and in vivo anti-inflammatory efficacy studies

Lecithin-based nanocapsule loading sucupira (Pterodon emarginatus) oil effects in experimental mucositis

“…In this sense, it has been demonstrated that nanocarriers containing anti-inflammatory molecules are considered potential treatments approach since they are able to accumulate in the inflammed sites [19] . In addition, the presence of lipid excipients or bioactive oils in those systems is reported to have anti-inflammatory effect in vivo [17] , [19] , [37] . Regarding its chemical composition, all the annotated compounds by LC-HRMS/MS and HPLC in SO, especially vouacapane diterpenoids and β-caryophyllene, match those already reported in the literature and are putative candidates as the main anti-inflammatory compound in sucupira oil [16] .…”

“…Sucupira oil (SO) has an amber color and can be extracted from the seeds. Its phytochemical composition demonstrates the presence of diverse terpenes, among them β-caryophyllene (CAR) and 6α,7β-Dihydroxyvouacapan-17β-oic acid may be associated with the anti-inflammatory activity [14] , [16] , [17] , [18] . However, whether SO works and its mechanism in treating intestinal mucositis have not been reported yet.…”

Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

“…Nanoemulsions containing optimized P. pubescens ethanolic extracts of the fruits were developed by Hoscheid et al [ 138 ]. To assess their efficiency and safety, another study by the same group [ 139 ], evaluated the anti-inflammatory activities of NE in a model of carrageenan-induced peritonitis. The NE containing ethanolic extracts of P. pubescens showed a significant inhibitory effect on leukocyte migration, even after 1 year of storage, indicating potential use in anti-inflammatory therapies, as well as in the treatment of arthritis [ 142 ].…”

Eficiência de sabonetes comerciais antissépticos contra bactérias patogênicas e análise dos rótulos

“…A análise do pH de uma formulação é de relevante importância, pois o pH de um produto deve manter-se igual durante todo o seu prazo de validade, uma vez que a alteração do pH pode significar alteração da estabilidade da formulação e levar o produto a causar sensibilidade. Sendo assim, o pH do produto é importante não somente para evitar irritações e exposição da pele a agentes agressores, principalmente bactérias (Blaak & Peter, 2018), mas para predizer a estabilidade química (Hoscheid, et al, 2017). Segundo a legislação brasileira, o pH dos sabonetes em barra deve ser em torno de 10,4, não ultrapassando 11,5 (Anvisa, 2008).…”