Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica

Dzoyem, Jean Paul; Melong, Raduis; Tsamo, Armelle Tontsa; Maffo, Timoleon; Kapche, Deccaux G. W. F.; Ngadjui, Bonaventure T.; McGaw, Lyndy Joy; Eloff, Jacobus Nicolaas

doi:10.1016/j.bjp.2016.08.011

Cited by 73 publications

(35 citation statements)

References 12 publications

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“…This finding was consistent with literature report on the antibacterial activity of indole-3carboxylic acid, from which a novel series of indole-3-carboxylic acid derivatives were previously reported to possess potent antibacterial activity against Enterococcus faecalis [104]. In addition, it has been reported that indole-3-carboxylic acid had weak cytotoxic effects on both normal and tumor cells, and its antioxidant activity is weak [103]. Recently, the indole-3-carboxylic acid (IAA) and other auxins have been shown to stimulate cell elongation, resulting in root growth initiation or an enhancement of nutritional elements absorption by the hosts [105,106].…”

Section: Bioactivity Evaluation Of Fungal Endophytessupporting

confidence: 92%

“…Besides, Xylaria species are widely distributed on the temperate to the tropical zones in the terrestrial globe, and fungi of this genus have been proved to be potential sources of novel secondary metabolites, and many of them have biological activities related to drug discovery, including cytotoxic, antimalarial, and antimicrobial activities [102]. μg/mL [103]. This finding was consistent with literature report on the antibacterial activity of indole-3carboxylic acid, from which a novel series of indole-3-carboxylic acid derivatives were previously reported to possess potent antibacterial activity against Enterococcus faecalis [104].…”

Section: Bioactivity Evaluation Of Fungal Endophytesmentioning

confidence: 99%

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Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Duan

Qin

et al. 2019

Preprint

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Background The present study involves diversity and biological activities of the endophytic fungal community from Distylium chinense , a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir. This study has been conducted hypothesizing that the microbial communities in the TGR area would contribute to the host plant tolerating a range of abiotic stress such as summer flooding, infertility, drought, salinity and soil erosion etc., and they may produce new metabolites, which may possess plentiful bioactive property, especially antioxidant activity. Therefore in the current study, the antioxidant, antimicrobial and anticancer activities of 154 endophytes recovered from D. chinense have been investigated. Furthermore, the active metabolites of the most broad-spectrum bioactive strain have also been studied.Results A total of 154 fungal endophytes were isolated from roots and stems. They were categorized into 30 morphotypes based on cultural characteristics and were affiliated with 27 different taxa. Among these, the most abundant fungal orders included Diaporthales (34.4%) and Botryosphaeriales (30.5%), which were predominantly represented by the species Phomopsis sp. (24.7%) and Neofusicoccum parvum (23.4%). Fermentation extracts were evaluated, screening for antioxidant, antimicrobial and anticancer activities. Among the 154 isolates tested, 99 (64.3%) displayed significant antioxidant activity, 153 (99.4%) exhibited inclusive antimicrobial activity against at least one tested microorganism and 27 (17.5%) showed exclusive anticancer activity against one or more cancer cell lines. Specifically, the crude extract of Irpex lacteus DR10-1 exhibited note-worthy bioactivities. Further chemical investigation on DR10-1 strain resulted in the isolation and identification of two known bioactive metabolites, indole-3-carboxylic acid ( 1 ) and indole-3-carboxaldehyde ( 2 ), indicating their potential roles in plant growth promotion and human medicinal value.Conclusion These results indicated that diverse endophytic fungal population inhabits D. chinense . One of the fungal isolate DR10-1 ( Irpex lacteus ) exhibited significant antioxidant, antimicrobial and anticancer potential. Further, its active secondary metabolites 1 and 2 also showed antioxidant, antimicrobial and anticancer potential.

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Section: Bioactivity Evaluation Of Fungal Endophytessupporting

confidence: 92%

Section: Bioactivity Evaluation Of Fungal Endophytesmentioning

confidence: 99%

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Duan

Qin

et al. 2019

Preprint

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“…The dyed fabrics have a "satisfactory effect" as long as any bacterial growth is detected on their surface. Different studies [8] reported the antibacterial activity of the madder dye, the responsible compounds for this effect being considered alizarin, purpurin and quinizarin [30][31][32] wich affect the bacterial cell wall. Due to their redox potential, these molecules form complexes with amino acids, inhibiting the synthesis of proteins and the bacterial growth [33].…”

Section: Antibacterial Activity Evaluationmentioning

confidence: 99%

Multi-functional effects of textiles dyed with madder roots powder (Rubiatinctoria)

et al. 2019

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In this study, 100% cotton knit was premordanted with mimosa tannin and mimosa tannin/alum and dyed with a dyestuff extracted from Madder root. The degree of exhaustion was carry out by UV-Vis spectroscopy. The color fastness to light, wash, rubbing (wet and dry) and perspiration of the mordanted and dyed fabrics were evaluated according to specific ISO standard. The samples were tested for ultraviolet protection and antibacterial activity against Staphylococcus aureus strains. The color fastness to washing and light are poor and the fastness to perspiration and rubbing is moderate. The dyed fabrics demonstrate an excellent UV protective effect and a good antibacterial activity. Even thin, the materials used for summer clothes dyed with madder could provide an effective and common mean to protect the human body against the harmful effects of UV rays.

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“…Gibberella fujikuroi is a fungal plant pathogen that produces a wide variety of secondary metabolites including gibberellins, carotenes, bikaverins, and hydroxylated anthraquinones (mainly pigments). Epicoccum nigrum is a plant pathogen and endophyte which produces metabolites such as colored pigments that can be used as antioxidant, anticancer, antibacterial and antifungal agents against other pathogenic fungi [18,19].…”

Section: Fungal Community Compositionmentioning

confidence: 99%

Field Fungal Diversity in Freshly Harvested Maize

Sun¹,

Shen²,

Li³

et al. 2019

IJBcRR

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Maize is a major crop in China and maize production in Heilongjiang Province ranks No.1 in the country in annual maize production in the whole country. Maize is prone to invasion by fungi and mycotoxins produced by these fungi are proven to be serious threats to animals as well as human health. Through high through-put sequencing we detected the dominant phylum to be Ascomycota; Dothideomycetes, Sordariomycetes, Eurotiomycetes and Tremellomycetes, Saccharomycetes were the dominant classes; Hypocreales, Eurotiales, Capnodiales, Saccharomycetales, Tremellales, and Pleosporales were the main orders; Nectriaceae, Trichocomaceae, Cladosporiaceae, Debaryomycetaceae, Tremellaceae, and Pleosporaceae were major families; Gibberella, Cladosporium, Papiliotrema, Penicillium, Scheffersomyces, Talaromyces, and Epicoccum were the most abundant phylotypes at the genus level. Epicoccum_nigrum, Gibberella_zeae, Papiliotrema_flavescens, and Scheffersomyces_shehatae were the dominant fungal species. Great fungal diversity was observed in the maize samples harvested in the five major maize-growing regions in Heilongjiang Province. Maize-1 in Nenjiang County was observed to have the greatest fungal diversity and abundance among the five regions. Since some of the fungal species are mycotoxin producing, it is necessary to take precautions to ensure the maize is stored under safe conditions to prevent the occurrence of mycotoxins and the growth and reproduction of other fungi which results in deterioration in the quality of maize.

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Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica

Cited by 73 publications

References 12 publications

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Multi-functional effects of textiles dyed with madder roots powder (Rubiatinctoria)

Field Fungal Diversity in Freshly Harvested Maize

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