Alkaloids and biological activity of beribá (Annona hypoglauca)

Rinaldi, Maria Valéria Nani; Díaz, Ingrit Elida Collantes; Suffredini, Ivana Barbosa; Moreno, Paulo Roberto Hrihorowitsch

doi:10.1016/j.bjp.2016.08.006

Cited by 34 publications

(17 citation statements)

References 41 publications

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“…SF32-33 had a dose- and time-dependent effect on P. aeruginosa ATCC 27853. Indeed, these effects were observed as soon as 6 h post-incubation of SF32-33 and lasted for 24 h. Although antibacterial activity has been attributed to fractions obtained from other plants of the Annona genus ( A. vepretorum and A. hypoglauca ), their MIC and MBC were much higher (≤100 mg/ml; Almeida et al, 2014; Rinaldi et al, 2016) in comparison to those observed for the EAF of A. glabra in our study (≤16 μg/ml).…”

Section: Discussioncontrasting

confidence: 70%

“…The hexane and chloroform fractions obtained from Annona vepretorum leaves display antimicrobial activity against Escherichia coli, Klebsiella pneumoniae , and Staphylococcus aureus (Almeida et al, 2014). Additionally, Rinaldi and collaborators showed that the methanol, dichloromethane, and ethyl acetate fractions (EAFs) obtained from Annona hypoglauca stems inhibited the growth of Staphylococcus aureus and Enterococcus faecalis (Rinaldi et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

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Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls

et al. 2016

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Pseudomonas aeruginosa is an important pathogen in opportunistic infections in humans. The increased incidence of antimicrobial-resistant P. aeruginosa isolates has highlighted the need for novel and more potent therapies against this microorganism. Annona glabra is known for presenting different compounds with diverse biological activities, such as anti-tumor and immunomodulatory activities. Although other species of the family display antimicrobial actions, this has not yet been reported for A. glabra. Here, we investigated the antimicrobial activity of the ethyl acetate fraction (EAF) obtained from the leaf hydroalcoholic extract of A. glabra. EAF was bactericidal against different strains of P. aeruginosa. EAF also presented with a time- and concentration-dependent effect on P. aeruginosa viability. Testing of different EAF sub-fractions showed that the sub-fraction 32-33 (SF32-33) was the most effective against P. aeruginosa. Analysis of the chemical constituents of SF32-33 demonstrated a high content of flavonoids. Incubation of this active sub-fraction with P. aeruginosa ATCC 27983 triggered an endothermic reaction, which was accompanied by an increased electric charge, suggesting a high binding of SF32-33 compounds to bacterial cell walls. Collectively, our results suggest that A. glabra-derived compounds, especially flavonoids, may be useful for treating infections caused by P. aeruginosa.

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Section: Discussioncontrasting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls

et al. 2016

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“…3). 43 The crude extract showed a lethal effect against MCF-7 and KM-12 tumor cells. The isoboldinecontaining fraction, which also contains nornuciferine and anonaine, exhibited cytotoxic activity, with a lethality of 11.6% against MCF-7 cells and 14.4% against KM-12 cells.…”

Section: Other Constituentsmentioning

confidence: 95%

“…Four aporphine alkaloids—actinodaphnine, anonaine, isoboldine, and nornuciferine—were identified in A. hypoglauca dried steam extract (Fig. ) . The crude extract showed a lethal effect against MCF‐7 and KM‐12 tumor cells.…”

Section: Other Constituentsmentioning

confidence: 99%

Annona species (Annonaceae): a rich source of potential antitumor agents?

Tundis

Xiao

Loizzo

2017

Annals of the New York Academy of Sciences

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Plants have provided the basis of traditional medicine systems throughout the world for thousands of years and continue to yield molecules for new remedies. We analyzed studies published from 2009 to 2016 on the Annona species (Annonaceae), including A. coriacea, A. crassifolia, A. hypoglauca, A. muricata, A. squamosa, A. sylvatica, and A. vepretorum, as sources of potential antitumor agents. Here, we report and discuss the mechanisms of action and structure-activity relationships of the most active Annona constituents. Annonaceous acetogenins are one of the most promising classes of natural products, owing to their potential antitumor activity. However, their neurotoxicity should not be underestimated.

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“…Nevertheless, it is possible to take advantages of the agrowaste by converting it into human food and manufacturing it to achieve horizontal agriculture, protect the environment from pollution, improve agricultural products, and provide employment opportunities in the agricultural sector. Thus, improvement of the economic situation, environment as well as rise in the health and social level, especially in rural areas, can be witnessed [4]. Furthermore, the highest amount of agrowaste was obtained during harvest, collection of crops, and preparation for marketing.…”

Section: Introduction mentioning

confidence: 99%

Investigation on the Antibacterial Activity and Phytochemical Screening of the Fruit Seed Extracts of Agro Waste

Asaad¹,

Desa²,

Baharum³

et al. 2019

UCMS

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The primary objective of this study is to evaluate the seed extracts from agro waste to examine the effectiveness of antimicrobial. Therefore, by using the disc diffusion assay, the antibacterial activity was evaluated along with two medically important bacterial pathogens such as methicillin resistant Staphylococcus aureus (S. aureus) (MRSA) and Escherichia coli (E. coli) in the seed extracts of Cucurbita sp., Carica papaya L., Nephelium lappaceum, Mangifera indica, Durio zibethius and Artocarpus heterphyllus Lam seeds. Seed extracts of agro waste were analyzed for the phytochemical constituents. Analysis of the qualitative phytochemical indicated the importance of phytochemical compounds for instance glycosides, saponins, flavanoids, tannins and alkaloids. Variations had been seen in the inhibition zone depending on the species and different seed extracts concentrations used for bacteria, the highest inhibition zone observed for M. indica and C. papaya L. The obtained data of this study presented greater insights which allow the use of seed extracts that were obtained from the agro-waster, to be used as raw materials for food, chemical, and pharmaceutical industries.

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Alkaloids and biological activity of beribá (Annona hypoglauca)

Cited by 34 publications

References 41 publications

Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls

Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls

Annona species (Annonaceae): a rich source of potential antitumor agents?

Investigation on the Antibacterial Activity and Phytochemical Screening of the Fruit Seed Extracts of Agro Waste

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