Natural products assessed in animal models for orofacial pain – a systematic review

Siqueira-Lima, Pollyana S.; Silva, Juliane C.; Quintans, Jullyana S.S.; Antoniolli, Ângelo Roberto; Saravanan, S.; Barreto, Rosana S.S.; Santos, Márcio Roberto Viana dos; Almeida, Jackson R.G.S.; Bonjardim, Leonardo Rigoldi; Menezes, Irwin Rose Alencar de; Quintans‐Júnior, Lucindo J.

doi:10.1016/j.bjp.2016.06.005

Cited by 18 publications

(8 citation statements)

References 90 publications

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“…In recent years, some reports relate pathogen infection to the development and progression of chronic inflammation. In this systematic review, we found 9 studies reporting inflammatory conditions induced by microorganisms or their components, including LPS from E. coli , complete Freund's adjuvant, S. flexneri , and P. multocida [22, 31, 34, 36, 39, 40, 44, 50]. LPS is the major cause of endotoxemia and sepsis.…”

Section: Resultsmentioning

confidence: 99%

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Lavor

Fernandes

Teles

et al. 2018

Oxidative Medicine and Cellular Longevity

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Inflammatory diseases result from the body's response to tissue damage, and if the resolution is not adequate or the stimulus persists, there will be progression from acute inflammation to chronic inflammation, leading to the development of cancer and neurodegenerative and autoimmune diseases. Due to the complexity of events that occur in inflammation associated with the adverse effects of drugs used in clinical practice, it is necessary to search for new biologically active compounds with anti-inflammatory activity. Among natural products, essential oils (EOs) present promising results in preclinical studies, with action in the main mechanisms involved in the pathology of inflammation. The present systematic review summarizes the pharmacological effects of EOs and their compounds in in vitro and in vivo models for inflammation. The research was conducted in the following databases: PubMed, Scopus, BIREME, Scielo, Open Grey, and Science Direct. Based on the inclusion criteria, 30 articles were selected and discussed in this review. The studies listed revealed a potential activity of EOs and their compounds for the treatment of inflammatory diseases, especially in chronic inflammatory conditions, with the main mechanism involving reduction of reactive oxygen and nitrogen species associated with an elevation of antioxidant enzymes as well as the reduction of the nuclear factor kappa B (NF-κB), reducing the expression of proinflammatory cytokines. Thus, this review suggests that EOs and their major compounds are promising tools for the treatment of chronic inflammation.

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Section: Resultsmentioning

confidence: 99%

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Lavor

Fernandes

Teles

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…The risk of bias and quality of preclinical evidences were assessed using a checklist adapted from Hooijmans et al [ 26 ] and Siqueira-Lima et al [ 27 ]. This analysis allowed evaluating the methodological quality of the selected manuscripts regarding the outcome measurements, randomization of treatment allocation, blinded drug administration, blinded outcome assessment, appropriate description of the doses and routes of administration used, and appropriately reported statistical analysis of data.…”

Section: Methodsmentioning

confidence: 99%

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Teles

Diniz

Pinto

et al. 2018

Oxidative Medicine and Cellular Longevity

138

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Alzheimer's and Parkinson's diseases are considered the most common neurodegenerative disorders, representing a major focus of neuroscience research to understanding the cellular alterations and pathophysiological mechanisms involved. Several natural products, including flavonoids, are considered able to cross the blood-brain barrier and are known for their central nervous system-related activity. Therefore, studies are being conducted with these chemical constituents to analyze their activities in slowing down the progression of neurodegenerative diseases. The present systematic review summarizes the pharmacological effects of flavonoids in animal models for Alzheimer's and Parkinson's diseases. A PRISMA model for systematic review was utilized for this search. The research was conducted in the following databases: PubMed, Web of Science, BIREME, and Science Direct. Based on the inclusion criteria, 31 articles were selected and discussed in this review. The studies listed revealed that the main targets of action for Alzheimer's disease therapy were reduction of reactive oxygen species and amyloid beta-protein production, while for Parkinson's disease reduction of the cellular oxidative potential and the activation of mechanisms of neuronal death. Results showed that a variety of flavonoids is being studied and can be promising for the development of new drugs to treat neurodegenerative diseases. Moreover, it was possible to verify that there is a lack of translational research and clinical evidence of these promising compounds.

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“…Among the major components found, terpenes were more highlighted, such as fenchone (24.8 %), cubebol (6.9 %) and limonene (5.4 %) (Rolim, 2013[ 44 ]). Such data can contribute to a better understanding of the pharmacological effects of the extract under study since the terpenes have been described for their analgesic and anti-inflammatory properties, mainly to acute and inflammatory pains (Guimarães et al, 2013[ 15 ], 2014[ 16 ]; Quintans-Júnior et al, 2013[ 41 ]; Quintans et al, 2014[ 39 ]; Siqueira-Lima et al, 2014[ 48 ], 2016[ 49 ], 2017[ 50 ]).…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD analysis, antinociceptive and anti-inflammatory properties of the ethanolic extract of Hyptis umbrosa in mice

Anjos

Araújo-Filho

Duarte

et al. 2017

EXCLI Journal; 16:Doc14; ISSN 1611-2156

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Natural products assessed in animal models for orofacial pain – a systematic review

Cited by 18 publications

References 90 publications

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

HPLC-DAD analysis, antinociceptive and anti-inflammatory properties of the ethanolic extract of Hyptis umbrosa in mice

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