Protective effect of Rheum turkestanikum root against doxorubicin-induced toxicity in H9c2 cells

Hosseini, Azar; Rajabian, Arezoo

doi:10.1016/j.bjp.2016.02.004

Cited by 15 publications

(19 citation statements)

References 24 publications

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“…cum administration improved renal toxicity following cisplatin [20], mercuric chloride [21] and STZ-induced renal toxicity [8]. The recent studies have reported, R.turkestanicum scavenged free radical and reduced oxidative stress in cardiac cells [9]. According to different studies, R.turkestanicun has high antioxidant activity, therefor reduction of HCBD toxicity may be related to its anti-oxidant potential.…”

Section: Discussionmentioning

confidence: 99%

“…tenuated the nephrotoxicity of HCBD such as safranal [5], rutin [6], pomegranate seed oil [7]. Our recent studies have shown Rheum turkestanicum has antidiabetic effect [8] and cardio protective effect against doxorubicin [9,10]. These effects are related due to the presence of different ingredients which are found in R.turkestanicum and have anti-oxidant activity.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

et al. 2019

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Hexachlorobutadien is nephrotoxic agent in rodents. The mechanism of toxicity includes generation of free radicals, depletion of thiol groups and production of toxic metabolites. Antioxidant compounds may reduce HCBD-nephrotoxicity. In this research we investigated the effect of Rheum turkeatanicum extract against HCBD-toxicity. The animals were divided to 4 groups which were including control (saline, 1 mL/kg), HCBD (100 mg/kg) and treatment groups which received extract at doses 100 and 200 mg/kg. The extract were administered as intraperitoneally (i.p.) 1 h before HCBD injection (i.p.). The animals were anesthetized by ether, 24 h after HCBD administration. The results showed elevation of serum creatinine, serum urea, urinary protein, urinary glucose, malondialdehyde levels in kidney and reduction of thiol in kidney by HCBD. The histopathological studies showed that there was apoptosis and necrosis in HCBD treated groups. Administration of R.turkestanicum reduced HCBD toxicity. The extract reduced hitopathological changes in kidney. It may be concluded that the nephroprotective effect of extract may be due to different mechanisms such as antioxidant activity or by decreasing the toxic metabolites of HCBD or inhibition of enzymes which are involved in the bioactivation of HCBD such as glutathione-S-transferase (GST) or cysteine-S-conjugate β-lyase.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

et al. 2019

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“…R. turkestanicum root was traditionally used as an antihypertensive, anticancer, and antidiabetic compound [12]. R. turkestanicum reduces doxorubicin toxicity in H9c2 cardiomyocyte cells via reduction of ROS generation [13]. According to recent studies, there are antioxidant compounds in Rheum species.…”

Section: Introductionmentioning

confidence: 99%

Rheum turkestanicum reduces glutamate toxicity in PC12 and N2a cell lines

Rajabian¹,

Sadeghnia²,

Moradzadeh³

et al. 2018

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Glutamate is considered to be responsible for the pathogenesis of many neurodegenerative diseases. Reactive oxygen species (ROS) production is considered to be involved in the glutamate-induced apoptosis process. In this study, we investigated the neuroprotective effects of Rheum turkestanicum in the glutamate-induced rat pheochromocytoma (PC12 cells) and mouse neuroblastoma (N2a) cell lines. Rutin as an antioxidant was used as positive control. Glutamate cytotoxicity was accompanied by an increment of malondialdehyde (MDA) content, ROS generation and apoptosis induction. However, pretreatment with the root extract of R. turkestanicum significantly reduced MDA content, ROS generation and apoptotic cell death. Also rutin at a dose of 100 µM reduced ROS production and protected against glutamate toxicity. Also the quantification of rutin in R. turkestanicum extract was achieved and was about 0.11% ± 0.01 w/w. All these findings indicated that R. turkestanicum protected PC12 and N2a cells against glutamate-induced oxidative cell death and apoptosis and might raise the possibility of R. turkestanicum usage as a neuroprotective agent.

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“…Recent studies have suggested that medicinal herbs may attenuate cardiotoxicity of doxorubicin due to having anti-oxidant ingredients [61] . Our previous work showed that exposure of H9C2 cells to Soxhlet extract of R. turkestanicum at doses of 25–200 μg/mL reduced doxorubicin cardiotoxicity through reducing free radicals, lipid peroxidation and apoptosis [62] . This effect was comparable to N-acetylcysteine, as a control antioxidant.…”

Section: Introductionmentioning

confidence: 98%

Pharmacological properties of Rheum turkestanicum Janisch

Ghorbani

Amiri

Hosseini

2019

Heliyon

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Medicinal herbs have been increasingly used worldwide for diseases prevention and treatment. Rheum turkestanicum Janisch. is a perennial shrub of the Polygonaceae family. Genus Rheum includes more than 60 species growing around the world which are used in foods and traditional medicines. R. turkestanicum is believed to be able to improve different kinds of disorders including diabetes, hypertension, jaundice and cancer. In recent years, this medicinal plant has been a subject of many experimental studies to document its health-beneficial properties. These studies have revealed antidiabetic, anticancer, nephroprotective, cardioprotective, and hepatoprotective properties of R. turkestanicum. The presence of flavonoids (e.g. epicatechin and quercetin) and anthraquinones (e.g. chrysophanol, physcion, and emodin) in R. turkestanicum justifies its health-beneficial effects. Nevertheless, possible therapeutic applications and safety of this plant still need to be elucidated in further clinical studies.

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Protective effect of Rheum turkestanikum root against doxorubicin-induced toxicity in H9c2 cells

Cited by 15 publications

References 24 publications

Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

Rheum turkestanicum reduces glutamate toxicity in PC12 and N2a cell lines

Pharmacological properties of Rheum turkestanicum Janisch

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