Sesquiterpene lactones from Hedyosmum brasiliense induce in vitro relaxation of rat aorta and corpus cavernosum

Leitolis, Amanda; Amoah, Solomon Kweku Sagoe; Biavatti, Maique W.; Silva-Santos, José Eduardo da

doi:10.1016/j.bjp.2016.01.005

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…A general characteristic of SLs is the occurrence of the γ-lactone ring, which contains the α-methylene group. The key combinations of the α-methylene-γ-lactone comprise a few ester groups [35,[116][117][118][119][120]. SLs are reputable across the plant kingdom that widespread in the families such as Asteraceae, Cactaceae, Euphorbiaceae, Solanaceae, Apiaceae, Acanthaceae, Amaranthaceae, Polygonaceae, Aristolochiaceae, Burseraceae, Illiciaceae, Magnoliaceae, Menispermaceae, Coriariaceae, Chloranthaceae, Lamiaceae, Lauraceae, and Winteraceae [49,50,55].…”

Section: Sesquiterpene Lactones (Sls)mentioning

confidence: 99%

Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

et al. 2021

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Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto double) significantly upto 2030. The poor cholinergic transmission at the synapse is considered to be one of the main reasons behind the progression and occurrence of this disorder. Natural inhibitors of acetylcholine (ACh) such as galanthamine and rivastigmine are used commercially in the treatmentof AD. The biomolecules such assesquiterpenes, possess a great structural diversity and are responsible for a plethora of pharmacological properties. The potential of various sesquiterpenes as anticholinesterase has been reviewed in this article. For this purpose, the various databases, mainly PubMed, Scopus, and Web of Science were investigatedwith different keywords such as “sesquiterpenes+acetylcholinesterase” and “sesquiterpenes+cholinesterase+inhibitors” in the surveyed time frame (2010–2020). A vast literature was evident in the last decade, which affirms the potential of various sesquiterpenes in the improvement of cholinergic transmission by inhibiting the AChE. After data analysis, it was found that 12 compounds out of a total of 58 sesquiterpenes were reported to possess IC50 < 9μM and can be considered as potential candidates for the improvement of learning and memory. Sesquiterpene is an important category of terpenoids, found to possess a large spectrum of biological activities. The outcome of the review clearly states that sesquiterpenes (such as amberboin, lipidiol,etc) from herbs could offer fresh, functional compounds for possible prevention and treatment of AD.

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Section: Sesquiterpene Lactones (Sls)mentioning

confidence: 99%

Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

et al. 2021

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“…Its leaves have been used in folk medicine to treat migraine, ovarium dysfunction, foot fungi, rheumatism, stomach pain, and as a diuretic [ 1 , 2 ]. Chemical and pharmacological studies with the aerial parts of H. brasiliense indicated analgesic, anxiolytic, antidepressive, and aphrodisiac effects for the crude extracts and for some isolated sesquiterpene lactones [ 11 , 12 , 13 , 14 , 15 , 16 ]. There are also some reports on the antimicrobial activity for the ethanol extract [ 17 ] and the essential oils [ 18 , 19 ], however none of them could attribute the observed bioactivity to a specific compound.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils

et al. 2017

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Background: Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) is a dioecious shrub popularly used in Brazil to treat foot fungi and rheumatism. This work investigated the chemical composition, antifungal, and antioxidant activities of flowers and leaves of H. brasiliense essential oils; Methods: H. brasiliense male and female flowers and leaves were collected at Ilha do Cardoso (São Paulo) and the essential oils were extracted by hydrodistillation and analyzed by GC/MS and their similarity compared by Principal Component Analysis. Antifungal activity was performed by bioautography and antioxidant potential by 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) free radical scavenging and β-carotene/linoleic acid system; Results: The major compounds for all oils were sabinene, curzerene, and carotol, but some differences in their chemical composition were discriminated by Principal Component Analysis (PCA) analysis. Bioautography showed two antifungal bands at Rf’s 0.67 and 0.12 in all samples, the first one was identified as curzerene. The oils presented stronger antioxidant potential in β-carotene/linoleic acid bioassay, with IC50’s from 80 to 180 μg/mL, than in DPPH assay, with IC50’s from 2516.18 to 3783.49 μg/mL; Conclusions: These results suggested that curzerene might be responsible for the antifungal activity of H. brasiliense essential oils. Besides, these essential oils exhibited potential to prevent lipoperoxidation, but they have a weak radical scavenger activity.

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“…However, an important issue is that the traditional uses of preparations derived from Hedyosmum plants do not show relevant toxicological properties, supporting the fact that they can be considered generally recognized as safe; similar to other medicinal plants currently used in modern health products. In particular, preliminary studies on H. orientale and H. sprucei produced promising results, and notably numerous investigations (Martini et al (2007); Tolardo et al (2010); Gonçalves et al (2012); Leitolis et al (2016)) into their antidepressant activities and effects on erectile dysfunction suggest that they deserve further study. This framework highlights the importance of matching ethnobotanical and pharmacological studies to exploit the bioactivities related to human diseases for further modern applications.…”

Section: Critical Assessments Of the Papers Reviewed And Final Discussionmentioning

confidence: 99%

“…The sesquiterpene 13HDS, isolated from the leaves and stems of H. brasiliense, was able (812 μM) to inhibit [ 3 H] glutamate binding and [ 3 H] glutamate uptake by synaptic vesicles in vitro. Leitolis et al (2016) investigated the relaxant effects of two compounds, 13-hydroxy-8,9-dehydroshizukanolide (podoandin) and 15acetoxy-isogermafurenolide (elemanolide), isolated from H. brasiliense and the effects of the hexane fraction of the ethanolic extract of the leaves (15 days) on endothelium-intact and endothelium-denuded rat aortic rings and strips of corpus cavernosum. The results of this study support the aphrodisiac effects of H. brasiliense extracts and its components (ranging from 49.5 to 65.9% at 100 μM) reported in ethnobotanical studies (Reitz et al, 1965).…”

Section: Analgesic and Antinociceptive Effectmentioning

confidence: 99%

Ethnopharmacology, phytochemistry and pharmacology of the genus Hedyosmum (Chlorantaceae): A review

Radice

Tasambay

Pérez

et al. 2019

Journal of Ethnopharmacology

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Sesquiterpene lactones from Hedyosmum brasiliense induce in vitro relaxation of rat aorta and corpus cavernosum

Cited by 8 publications

References 28 publications

Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils

Ethnopharmacology, phytochemistry and pharmacology of the genus Hedyosmum (Chlorantaceae): A review

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