Antischistosomal activity from Brazilian marine algae

Stein, Erika Mattos; Machado, Levi Pompermayer; Roffato, Henrique K.; Miyasato, Patrícia A.; Nakano, Eliana; Colepicolo, Pio; Andreguetti, Daniel Xavier

doi:10.1016/j.bjp.2015.09.005

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…L. dendroidea extracts were previously selected for bioguided fractionation together with other algal species in our trial studies [9,10]. In the present study, extracts of L. dendroidea, as shown in the GC-MS chromatograms in the 20-60 min range (Figure 2), revealed samples to be complex mixtures that contained a wide variety of volatile compounds from different chemical classes according to searches of various GC-MS libraries.…”

Section: Bioguided Fractionation Of Laurencia Dendroidea Led To Elatolmentioning

confidence: 54%

“…Recently, we detected the in vitro activity of seaweed extracts against S. mansoni. Three out of the thirteen tested extracts induced lethal effects in the exposed worms [9]. In a more comprehensive screening, in addition to the effects on S. mansoni, the molluscicidal activity was evaluated, indicating the activity of 22 out of 37 species in at least one of the models [10].…”

Section: Introductionmentioning

confidence: 99%

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Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control

et al. 2022

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Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (−)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos.

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Section: Bioguided Fractionation Of Laurencia Dendroidea Led To Elatolmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control

et al. 2022

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“…Recently, we detected the in vitro activity of seaweed extracts against S. mansoni . Three out of the 13 tested extracts induced lethal effects in the exposed worms [ 19 ]. In the present study, a more comprehensive trial was performed with the screening of 37 species of Brazilian macroalgae for schistosomicidal and molluscicidal activity searching for compounds of potential use in the treatment and control of schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control

et al. 2021

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Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against Biomphalaria glabrata embryos and schistosomicidal activities against Schistosoma mansoni. Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC–MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against B. glabrata veliger embryos in the Laurencia/Laurenciella set, 5 hits against B. glabrata blastula embryos, and 31 against S. mansoni in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identification.

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“…Sources of new drugs for the treatment of protozoal infections can be natural products, synthetic molecules, or existing drugs with an extended spectrum of indications. A combination of new methods, including genetic modification of pathogens, bioimaging, molecular docking [7], and robotics has led to the standardization of high-throughput screening platforms for drug discovery [8]. For the treatment of protozoal infections, new effective agents are needed which do not cause at all or cause a minimum of side effects and to which protozoa will not develop resistance in a short time.…”

Section: Introductionmentioning

confidence: 99%

Antiparasitic Effects of Sulfated Polysaccharides from Marine Hydrobionts

et al. 2021

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This review presents materials characterizing sulfated polysaccharides (SPS) of marine hydrobionts (algae and invertebrates) as potential means for the prevention and treatment of protozoa and helminthiasis. The authors have summarized the literature on the pathogenetic targets of protozoa on the host cells and on the antiparasitic potential of polysaccharides from red, brown and green algae as well as certain marine invertebrates. Information about the mechanisms of action of these unique compounds in diseases caused by protozoa has also been summarized. SPS is distinguished by high antiparasitic activity, good solubility and an almost complete absence of toxicity. In the long term, this allows for the consideration of these compounds as effective and attractive candidates on which to base drugs, biologically active food additives and functional food products with antiparasitic activity.

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Antischistosomal activity from Brazilian marine algae

Cited by 7 publications

References 23 publications

Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control

Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control

The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control

Antiparasitic Effects of Sulfated Polysaccharides from Marine Hydrobionts

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