Activity of Fabaceae species extracts against fungi and Leishmania: vatacarpan as a novel potent anti-Candida agent

Santana, Dandara Braga; Costa, Raphaella Correia da; Araújo, Renata Mendonça; Paula, José Elías de; Silveira, Edilberto R.; Braz-Filho, Raimundo; Espindola, Laïla Salmen

doi:10.1016/j.bjp.2015.07.012

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…The minimum inhibitory concentration in hexane and water were low, observed only with Issatchenkia orientalis when their development was stymied with the hexane extract. The minimum inhibitory concentration activity of the extracts against the test fungi agrees with earlier works on several plants'extracts with acetone and ethanol as solvents of maceration (Erturk, 2006;Awouafack et al, 2013;Santana et al, 2015). The minimum fungicidal concentration which is the concentration of the extracts with no observable growth of fungi after incubation presage that acetone and ethanol extracts of the leaves of M. macrostachyum had a low minimum fungicidal concentration on Aspergillus niger, Issatchenkia orientalis, Meyerozyma caribbica, Meyerozyma guilliermondii and Trichoderma harzianum at ≤0.5 mg/ml.…”

Section: Discussionsupporting

confidence: 88%

Chemical Composition, Toxicity and Antifungal Activities of Megaphrynium macrostachyum (K. Schum) Leaf Extract against Foodborne Fungi

Adeogun¹,

Adekunle²,

Adongbede³

et al. 2017

Not Sci Biol

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This study aimed to examine the preservative potential of Megaphrynium macrostachyum on fungi responsible for the deterioration of orange juice and corn Jell-O. The phytochemicals from plants' leaves were extracted with four solvents: acetone, aqueous, ethanol and hexane. The solvents were differently and tested against fungi isolated from orange juice and corn Jell-O using disc diffusion method. Phytochemical screening of the extracts from the leaves was carried out, and the most active extract was tested via GC-MS for the essential oils and HPLC fingerprinting. The toxicity test of the extracts against brine shrimp was carried out after exposure for 24 hours. The toxicity test showed that the extracts were non-toxic on the Brine Shrimps at LC 50 (379.21μg/ml and 107.21μg/ml for aqueous and ethanol extracts). The qualitative phytochemical test reported the presence of alkaloids, tannins, saponins, flavonoids, steroids and terpenoids in different extracts of the plant' leaves. The quantitative phytochemical determination of the most active extract revealed alkaloids with the highest contents of 107.48 mg/100 g. The GC-MS analyses of the fresh leaves of the plants revealed the presence of isodecane with the highest percentage at 15.56%. The GC-MS analyses of the dried leaves revealed isodecane with the highest percentage at 10.43%. The HPLC analysis revealed the presence of various phytochemical constituents in the dried leaves. This study has been able to establish the potency of Megaphrynium macrostachyum leaves on fungi associated with the spoilage of Citrus sinensis (orange) juice and Corn Jell-O ('Eko') which contribute to tremendous research towards the use and acknowledgment of natural antimicrobials for the preservation of food.

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Section: Discussionsupporting

confidence: 88%

Chemical Composition, Toxicity and Antifungal Activities of Megaphrynium macrostachyum (K. Schum) Leaf Extract against Foodborne Fungi

Adeogun¹,

Adekunle²,

Adongbede³

et al. 2017

Not Sci Biol

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“…Despite the large molecular weights of natural products which renders some of them less druglike, structural diversity, large chemical space and safety are characteristics that overrides synthetic alternatives. Treatments using extracts from plant families from endemic regions include Fabaceae [32], Annonaceae, Euphorbiaceae [31,33,34], Rutaceae [35][36][37], Myrsinaceae [31,38], Liliaceae [39], Araliaceae [38], Simaroubaceae [40], as well as endophytes genera Alternaria [41], Arthrinium, Penicillium, Cochloibus, Fusarium, Colletotrichum, and Gibberella [42]. Additionally, the exploration of marine natural products has led to the identification of interesting natural products with diverse biomolecular functions [43,44].…”

Section: Natural Products As Possible Sources Of New Drugs Against Leishmaniasismentioning

confidence: 99%

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

Sakyi

Amewu

Devine

et al. 2021

Nat. Prod. Bioprospect.

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Despite advancements in the areas of omics and chemoinformatics, potent novel biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The socioeconomic burden of leishmaniasis remains alarming in endemic regions. Currently, reports from existing endemic areas such as Nepal, Iran, Brazil, India, Sudan and Afghanistan, as well as newly affected countries such as Peru, Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial treatment. As a result, effective antileishmanial agents which are safe and affordable are urgently needed. Natural products from both flora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical agents. This review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last decade. Furthermore, IC50/EC50, cytotoxicity and suggested mechanisms of action of some of these natural products are provided. The natural product classification includes alkaloids, terpenes, terpenoids, and phenolics. The plethora of reported mechanisms involve calcium channel inhibition, immunomodulation and apoptosis. Making available enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevance. Graphic Abstract

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“…Zamamidine D had an IC 50 of 2 µg/mL against C. neoformans but was weakly active against other fungal and bacterial strains tested [39]. From another Okinawan marine sponge Pseudoceratina sp., ceratinadin A and B (46,47) were isolated with MIC values of 4 and 8 µg/mL, respectively, against C. neoformans and 2 and 4 µg/mL, respectively, against C. albicans [40]. From an extract of the sponge Pseudaxinella reticulata, several crambescin guanidine containing alkaloids were isolated.…”

Section: Natural Product Antifungal Leads From Spongesmentioning

confidence: 99%

“…The isoflavonoid vatacarpan (57) with an MIC of 1 μg/mL against C. albicans was isolated by bioassay-guided fractionation from the roots of Vatairea macrocarpa (Benth.) Ducke [46]. The biaryl ether laevicarpin (58) was isolated from leaves of Piper laevicarpu, known as "falsa-pimenteira" in Brazil [47].…”

Section: Natural Product Antifungal Leads From Plantsmentioning

confidence: 99%

A Decade of Antifungal Leads from Natural Products: 2010–2019

et al. 2019

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In this review, we discuss novel natural products discovered within the last decade that are reported to have antifungal activity against pathogenic species. Nearly a hundred natural products were identified that originate from bacteria, algae, fungi, sponges, and plants. Fungi were the most prolific source of antifungal compounds discovered during the period of review. The structural diversity of these antifungal leads encompasses all the major classes of natural products including polyketides, shikimate metabolites, terpenoids, alkaloids, and peptides.

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Activity of Fabaceae species extracts against fungi and Leishmania: vatacarpan as a novel potent anti-Candida agent

Cited by 10 publications

References 32 publications

Chemical Composition, Toxicity and Antifungal Activities of Megaphrynium macrostachyum (K. Schum) Leaf Extract against Foodborne Fungi

Chemical Composition, Toxicity and Antifungal Activities of Megaphrynium macrostachyum (K. Schum) Leaf Extract against Foodborne Fungi

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

A Decade of Antifungal Leads from Natural Products: 2010–2019

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