Comparative central effects of the aqueous leaf extract of two populations of Passiflora edulis

Abstract

Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c t Passiflora edulis Sims, Passifloraceae, has been used in Brazilian traditional folk medicine to the treatment of anxiety and insomnia. P. edulis is commonly known for its economic interests in Brazil. This species exhibits significant variability in the fruit rind color, then two subpopulations has been described (P. edulis fo. flavicarpa O. Deg. (PEF); P. edulis fo. edulis (PEE)). This study compared phytochemical profile and biological actions of aqueous leaf extract of PEE and PEF. HPLC analysis showed marked distinct chromatograms to the P. edulis varieties. However, in both extracts the major compounds observed were flavonoids C-glycosides. Behavioral studies showed that PEE (300 mg/kg, p.o.) and PEF (100 and 300 mg/kg, p.o.) reduced anxiety in the elevated plus maze test. PEE (300 and 1000 mg/kg, p.o.) and PEF (1000 mg/kg, p.o.) also induced antidepressant-like actions in the forced swimming test. PEE 1000 mg/kg significantly reduced distance moved, thus suggesting sedation. No alterations in sleeping time were observed with PEE and PEF extracts. In conclusion, despite the similarities between the biological actions observed for both P. edulis varieties, quite different phytochemical profile was herein reported. These data suggest that the anxiolytic and antidepressant actions are not due to a specific phytochemical component.

Inhibition of Pancreatic Lipase and Characterization by Extracts From Fruit Pomaces Cultivars Grown in Brazilian Semiarid

“…Peaks at Tr 7.03 (λmax 270, 342 nm), 8.19 (λmax 269, 348 nm) and 9.59 (λmax 271 and 339 nm) have comparable UV-DAD spectra to luteoline (λmax 270, 344 nm) suggesting presence of flavonoids derived from this compound. Studies in literature confirm presence of this flavonoid, its derivatives in passion fruit, apigenin, its derivatives were also characterized as belonging to this fruit (Zeraik & Yariwake, 2010;Ayres et al, 2015).…”

Caracterização de compostos bioativos de maracujá (>i<Passiflora tenuifila>/i<) e efeito do seu consumo sobre marcadores bioquímicos, microbiota intestinal em indivíduos eutróficos e obesos

“…Muitas espécies de passifloras estão associadas à atividade ansiolítica, sedativa, antidepresiva e contra distúrbios do sono (AYRES et al, 2015GAZOLA et al, 2018;KIM et al, 2019). Mais recentemente, foram reportados efeito anti-inflamatório, antidiabético, antimicrobiano neuroprotetores e antioxidantes para espécies nativas indicando o grande potencial biológico apresentado pelas mesmas CORRÊA et al, 2016;SHANMUGAM et al, 2018).…”

Phenolic content and antioxidant activity of parts of Passiflora edulis as a function of plant developmental stage

“…The genus Passiflora (family Passifloraceae) includes about 600 plant species (Ayres et al 2015;Wosch et al 2017) distributed in the tropical and subtropical regions around the world (Ayres et al 2015). Over 140 species were described to occur in Brazil, in which 83 of them are considered endemic (Gomes et al 2017) and 60 species produce edible fruits (Pertuzatti et al 2015).…”

“…Extracts of Passiflora species leaves have been used in folk medicine for treating neurosystem disorders, such as anxiety, migraine and insomnia (Zibadi & Watson 2004;Ayres et al 2015). Ethnobotanical studies show that the fruit pulp is used as cardiac tonic, moderate diuretic and digestive stimulant and to treat asthma, bronchitis, whooping cough and urinary infections (Zibadi & Watson 2004).…”