Stevia rebaudiana loaded titanium oxide nanomaterials as an antidiabetic agent in rats

Abstract

Revista Brasileira de Farmacognosia 25 (2015) [145][146][147][148][149][150][151] w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c t Stevia rebaudiana (Bertoni) Bertoni, Asteraceae, is a plant with hypoglycemic and antihyperlipidemic properties. S. rebaudiana (SrB) has become a lead candidate for the treatment of the diabetes mellitus. However, chronic administrations of S. rebaudiana are required to cause the normoglycemic effect. Importantly, nanomaterials in general and titanium dioxide (TiO 2 ) in particular have become effective tools for drug delivery. In this work, we obtained TiO 2 nanomaterials with SrB at different concentrations (10, 20 and 30 M) by sol-gel method. After this nanomaterials were characterized by Fourier transform infrared spectroscopy and transmission electron microscopy. Where it was demonstrated, the presence of the S. rebaudiana in TiO 2 nanomaterials, which were observed as hemispherical agglomerated particles of different sizes. The nanomaterials were evaluated in male rats whose diabetes mellitusphenotype was induced by alloxan (200 mg/kg, i.p.). The co-administration of TiO 2 -SrB (20 and 30 M) induced a significant and permanent decrease in the glucose concentration since 4 h, until 30 days post-administration. Likewise, the concentrations of insulin, glycosylated hemoglobin, cholesterol, and triacylglycerides showed a significant recovery to basal levels. The major finding of the study was that the TiO 2 -SrB (20 and 30 M) has a potent and prolonged activity antidiabetic. TiO 2 can be considered like an appropriated vehicle in the continuous freeing of active substances to treat of diabetes mellitus.

Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

“…The results of α-amylase inhibition as shown in Figure 11 demonstrate undoped TiO 2 nanoparticles and N-doped TiO 2 nanoparticles to be the potent candidates against diabetes mellitus. Previously, Stevia rebaudiana loaded TiO 2 nanoparticles have been proved potential antidiabetic agents via in vivo studies performed in rats [40]. N-doped TiO 2 nanoparticles possess more significant α-amylase inhibition (38.2%) as compared to bare TiO 2 nanoparticles (24.8%).…”

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

“…After 31 days of treatment, there was a significant and permanent decrease in blood glucose, glycosylated hemoglobin, TC, and TAG, along with a higher insulin concentration (P < 0.01) in animals treated with extract-loaded nanomaterial (20 and 30 µM) compared to the diabetic group treated with TiO 2 nanomaterial alone. TiO 2 nanomaterial could provide a sustained and controlled release of the plant extract which resulted in prolonged stimulation of insulin secretion (Langle et al, 2015). The previous study has shown nanoencapsulated stevioside in pluronic-F-68-poly-lactic acid (PLA) interestingly increased intestinal absorption, bioavailability, and provided a controlled release of the active component (Barwal et al, 2013).…”

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

“…Titanium nanoparticles have been produced by using titanium n-butoxide (Ti(OCH 2 CH 2 CH 2 CH 3 ) 4 ), metatitanic acid (TiO(OH) 2 ), titanium dioxide powder (TiO 2 ), or titanium tetraisopropoxide (Ti[OCH(CH 3 ) 2 ] 4 ) as a source of titanium ions and mixed with plant extracts [ 275 , 276 , 297 , 301 ]. Samyuktha et al prepared them using Azadirachta indica leaf aqueous extract and titanium dioxide powder.…”

“…Their investigations on diabetic rats showed powerful and prolonged antidiabetic activity. Thus, they concluded that TiO 2 can be considered a suitable vehicle for the continuous release of active compounds in the treatment of diabetes [ 276 ].…”