Revista Brasileira de Farmacognosia 25 (2015) [145][146][147][148][149][150][151] w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c t Stevia rebaudiana (Bertoni) Bertoni, Asteraceae, is a plant with hypoglycemic and antihyperlipidemic properties. S. rebaudiana (SrB) has become a lead candidate for the treatment of the diabetes mellitus. However, chronic administrations of S. rebaudiana are required to cause the normoglycemic effect. Importantly, nanomaterials in general and titanium dioxide (TiO 2 ) in particular have become effective tools for drug delivery. In this work, we obtained TiO 2 nanomaterials with SrB at different concentrations (10, 20 and 30 M) by sol-gel method. After this nanomaterials were characterized by Fourier transform infrared spectroscopy and transmission electron microscopy. Where it was demonstrated, the presence of the S. rebaudiana in TiO 2 nanomaterials, which were observed as hemispherical agglomerated particles of different sizes. The nanomaterials were evaluated in male rats whose diabetes mellitusphenotype was induced by alloxan (200 mg/kg, i.p.). The co-administration of TiO 2 -SrB (20 and 30 M) induced a significant and permanent decrease in the glucose concentration since 4 h, until 30 days post-administration. Likewise, the concentrations of insulin, glycosylated hemoglobin, cholesterol, and triacylglycerides showed a significant recovery to basal levels. The major finding of the study was that the TiO 2 -SrB (20 and 30 M) has a potent and prolonged activity antidiabetic. TiO 2 can be considered like an appropriated vehicle in the continuous freeing of active substances to treat of diabetes mellitus.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.