Ethnopharmacological studies of Lippia origanoides

Oliveira, Danilo Ribeiro de; Leitão, Gilda Guimarães; Fernandes, Patrícia Dias; Leitão, Suzana Guimarães

doi:10.1016/j.bjp.2014.03.001

Cited by 43 publications

(19 citation statements)

References 33 publications

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“…Lippia berteroi Spreng, Lippia schomburgkiana Schauer) is an aromatic shrub up to 3 m in height, known popularly as “alecrim d’angola” and “salva-do-marajó”, growing wild in savanna areas of North Brazil [ 13 ]. Many studies have reported its biological activities such as antimicrobial [ 14 ], anti-hypertensive [ 15 ], antispasmodic, anti-inflammatory, analgesic [ 16 ] and antioxidant [ 17 ]. In addition, its essential oil (EO) presents a number of substances with antioxidant activity such as thymol, carvacrol and 1,8-cineole, which act as captors of free radicals, thus stressing the importance in combating damage from reactive oxygen species leading to premature aging [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Tyrosinase inhibitory activity, molecular docking studies and antioxidant potential of chemotypes of Lippia origanoides (Verbenaceae) essential oils

Silva

Andrade

et al. 2017

PLoS ONE

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The essential oils (EOs) of the aerial parts of Lippia origanoides (LiOr), collected in different localities of the Amazon region, were obtained by hydrodistillation and analyzed by GC and CG-MS. Principle component analysis (PCA) based on chemical composition grouped the oils in four chemotypes rich in mono- and sesquiterpenoids. Group I was characterized by 1,8-cineole and α-terpineol (LiOr-1 and LiOr-4) and group II by thymol (LiOr-2). The oil LiOr-3 showed β-caryophyllene, α-phellandrene and β-phellandrene as predominant and LiOr-5 was rich in (E)-nerolidol and β-caryophyllene. All samples were evaluated for antioxidant activity and inhibition of tyrosinase in vitro and in silico. The highest antioxidant activity by the DPPH free radical method was observed in LiOr-2 and LiOr-5 oils (132.1 and 82.7 mg TE∙mL-1, respectively). The tyrosinase inhibition potential was performed using L-tyrosine and L-DOPA as substrates and all samples were more effective in the first step of oxidation. The inhibition by samples LiOr-2 and LiOr-4 were 84.7% and 62.6%, respectively. The samples LiOr-1, LiOr-4 and LiOr-5 displayed an interaction with copper (II) ion with bathochromic shift around 15 nm. In order to elucidate the mechanism of inhibition of the main compounds, a molecular docking study was carried out. All compounds displayed an interaction between an oxygen and Cu or histidine residues with distances less than 4 Å. The best docking energies were observed with thymol and (E)-nerolidol (-79.8 kcal.mol-1), which suggested H-bonding interactions with Met281 and His263 (thymol) and His259, His263 ((E)-nerolidol).

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Section: Introductionmentioning

confidence: 99%

Tyrosinase inhibitory activity, molecular docking studies and antioxidant potential of chemotypes of Lippia origanoides (Verbenaceae) essential oils

Silva

Andrade

et al. 2017

PLoS ONE

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“…The Lippia genus (Verbenaceae Fam.) has been widely used as seasoning and in traditional medicine for treatments of gastrointestinal, genitourinary and respiratory diseases, as well as anti‐inflammatory and analgesic remedies . EO obtained from Colombian Lippia species exhibit a wide range of biological activities such as antioxidant , antiviral , antimicrobial , antiprotozoal and antigenotoxic .…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic Effect Against Ultraviolet Radiation‐induced DNA Damage of the Essential Oils from Lippia Species

Ruiz

Campo

Stashenko

et al. 2017

Photochem & Photobiology

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The antigenotoxicity against ultraviolet radiation (UV)-induced DNA damage of essential oils (EO) from Lippia species was studied using SOS Chromotest. Based on the minimum concentration that significantly inhibits genotoxicity, the genoprotective potential of EO from highest to lowest was Lippia graveolens, thymol-RC ≈ Lippia origanoides, carvacrol-RC ≈ L. origanoides, thymol-RC > Lippia alba, citral-RC ≈ Lippia citriodora, citral-RC ≈ Lippia micromera, thymol-RC > L. alba, myrcenone-RC. EO from L. alba, carvone/limonene-RC, L. origanoides, α-phellandrene-RC and L. dulcis, trans-β-caryophyllene-RC did not reduce the UV genotoxicity at any of the doses tested. A gas chromatography with flame ionization detection analysis (GC-FID) was conducted to evaluate the solubility of the major EO constituents under our experimental conditions. GC-FID analysis showed that, at least partially, major EO constituents were water-soluble and therefore, they were related with the antigenotoxicity detected for EO. Constituents such as p-cymene, geraniol, carvacrol, thymol, citral and 1,8-cineole showed antigenotoxicity. The antioxidant activity of EO constituents was also determined using the oxygen radical antioxidant capacity (ORAC) assay. The results showed that the antigenotoxicity of the EO constituents was unconnected with their antioxidant activity. The antigenotoxicity to different constituent binary mixtures suggests that synergistic effects can occur in some of the studied EO.

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“…Dentre as espécies do gênero Lippia, L. origanoides Kunth, conhecida popularmente como "alecrim-pimenta" ou "salvade-marajó", é utilizada popularmente para o tratamento de diversas afecções (Costa, Souza, Brito & Fontenelle, 2017 (Brasil, 2009). Esta variedade possui ação antibacteriana, antiespasmódica, anti-inflamatória e antioxidante, decorrente dos seus constituintes fenólicos e não-fenólicos (Botelho et al, 2007;Okhale, Nwanosike, Fatokun & Kunle, 2016;Oliveira, Leitão, Fernandes & Leitão, 2014;Sarrazin et al, 2015). Embora seja uma das espécies de Lippia mais estudadas (Botelho et al, 2008(Botelho et al, , 2016Oliveira, Oliveira, Carneiro, Silva & Costa, 2018), o conhecimento sobre as propriedades biológicas dos seus compostos ainda não está sedimentado e, portanto, ainda possui um grande potencial biotecnológico a ser explorado.…”

Section: Introductionunclassified

Atividade antimicrobiana dos extratos metanólicos de diferentes espécies do gênero Lippia

Trindade

Pereira-Filho

Neto

et al. 2021

RSD

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As espécies do gênero Lippia (Verbenaceae) possuem diversas moléculas bioativas, oriundas do seu metabolismo secundário, que apresentam atividade antimicrobiana, analgésica, antifúngica e imunomoduladora. Este estudo teve como objetivo avaliar a atividade antimicrobiana in vitro do extrato metanólico das folhas de L. alnifolia, L. origanoides, L. insignis e L. thymoides frente a microrganismos de importância clínica. Foi realizada uma triagem fitoquímica dos extratos das plantas e a avaliação da atividade antimicrobiana pelo método de difusão em disco, além da determinação da concentração inibitória mínima (MIC) frente às bactérias Bacillus subtilis, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus e Salmonella choleraesuis, e os fungos Candida albicans e Candida glabrata. A presença de saponinas, terpenos, esteroides, cumarinas, ácidos fenólicos e flavonoides foi observada na análise fitoquímica. Os extratos metanólicos das folhas de L. alnifolia, L. origanoides e L. insignis apresentaram atividade antimicrobiana contra todas os microrganismos testados. O extrato metanólico da L. thymoides apresentou atividade antimicrobiana frente aos microrganismos M. luteus, P. aeruginosa, S. aureus, C. albicans e C. glabrata. A maioria dos extratos apresentou atividade bacteriostática e todos os extratos apresentaram atividade fungistática para C. albicans e fungicida para C. glabrata. A utilização dos extratos de Lippia pode ser uma alternativa viável no tratamento de doenças infecciosas de origem bacteriana e fúngica.

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Ethnopharmacological studies of Lippia origanoides

Cited by 43 publications

References 33 publications

Tyrosinase inhibitory activity, molecular docking studies and antioxidant potential of chemotypes of Lippia origanoides (Verbenaceae) essential oils

Tyrosinase inhibitory activity, molecular docking studies and antioxidant potential of chemotypes of Lippia origanoides (Verbenaceae) essential oils

Antigenotoxic Effect Against Ultraviolet Radiation‐induced DNA Damage of the Essential Oils from Lippia Species

Atividade antimicrobiana dos extratos metanólicos de diferentes espécies do gênero Lippia

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