Melatonin prevents age-related hearing loss in the murin experimental model

Serra, Lucieny Silva Martins; Araújo, Juliana Gusmão de; Novanta, Gabriela Guenther Ribeiro; Lauand, Lucas; Silva, Eduardo Magalhães da; Kückelhaus, Selma Aparecida Souza; Sampaio, André Luiz Lopes

doi:10.1016/j.bjorl.2022.06.002

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…GRs are widely found in the human inner ear, especially the spiral ligament in the cochlea ( 52 ). Studies have shown that melatonin plays a role in delaying cell loss in spiral ligaments ( 53 ). In other words, the concentration of melatonin affects the efficacy of GCs in the treatment of ISSNHL.…”

Section: Discussionmentioning

confidence: 99%

Reassessment of oxidative stress in idiopathic sudden hearing loss and preliminary exploration of the effect of physiological concentration of melatonin on prognosis

Song,

Ouyang,

Xiong

et al. 2023

Front. Neurol.

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Background and purposeThe pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unclear, and there is no targeted treatment. This research aimed to verify the role of oxidative stress in ISSNHL and explore whether melatonin has a protective effect on hearing.Materials and methodsA total of 43 patients with ISSNHL and 15 healthy controls were recruited to detect the level of melatonin, reactive oxygen species (ROS), and total antioxidant capacity (TAC) in the blood and compared before and after treatment. Multivariate logistic regression models were performed to assess the factors relevant to the occurrence and improvement of ISSNHL.ResultsThe patients with ISSNHL showed significantly higher ROS levels than controls (4.42 ± 4.40 vs. 2.30 ± 0.59; p = 0.031). The levels of basal melatonin were higher (1400.83 ± 784.89 vs. 1095.97 ± 689.08; p = 0.046) and ROS levels were lower (3.05 ± 1.81 vs. 5.62 ± 5.56; p = 0.042) in the effective group as compared with the ineffective group. Logistic regression analysis showed that melatonin (OR = 0.999, 95% CI 0.997–1.000, p = 0.049), ROS (OR = 1.154, 95% CI 1.025–2.236, p = 0.037), and vertigo (OR = 3.011, 95% CI 1.339–26.983, p = 0.019) were independent factors associated with hearing improvement. Besides, the level of melatonin (OR = 0.999, 95% CI 0.998–1.000, p = 0.023) and ROS (OR = 3.248, 95% CI 1.109–9.516, p = 0.032) were associated with the occurrence of ISSNHL.ConclusionOur findings may suggest oxidative stress involvement in ISSNHL etiopathogenesis. The level of melatonin and ROS, and vertigo appear to be predictive of the effectiveness of hearing improvement following ISSNHL treatment.

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Section: Discussionmentioning

confidence: 99%

Reassessment of oxidative stress in idiopathic sudden hearing loss and preliminary exploration of the effect of physiological concentration of melatonin on prognosis

Song,

Ouyang,

Xiong

et al. 2023

Front. Neurol.

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“…Melatonin has strong anti-oxidant capacity that helps prevent or delay the dysfunction of cochlear OHCs [ 98 ], as well as the ototoxicity caused by cisplatin [ 99 ] and noise exposure-induced hearing loss [ 100 ]. However, melatonin cannot completely neutralize the occurrence of ARHL [ 101 ]. α-lipoic acid is a good anti-oxidant that has been shown to successfully prevent ARHL in rats [ 102 ].…”

Section: Pathophysiological Mechanisms and Treatment Strategies Of Arhlmentioning

confidence: 99%

Age-related hearing loss and its potential drug candidates: a systematic review

Hu,

Sun,

et al. 2023

Chin Med

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Background Age-related hearing loss (ARHL) is one of the main illnesses afflicting the aged population and has a significant negative impact on society, economy, and health. However, there is presently no appropriate therapeutic treatment of ARHL due to the absence of comprehensive trials. Objectives The goal of this review is to systematically evaluate and analyze recent statistics on the pathologic classifications, risk factors, treatment strategies, and drug candidates of ARHL, including that from traditional Chinese medicine (TCM), to provide potential new approaches for preventing and treating ARHL. Methods Literature related to ARHL was conducted in databases such as PubMed, WOS, China National Knowledge Infrastructure (CNKI), and Wanfang from the establishment of the database to Jan, 2023. The pathology, causal factor, pathophysiological mechanism, treatment strategy, and the drug candidate of ARHL were extracted and pooled for synthesis. Results Many hypotheses about the etiology of ARHL are based on genetic and environmental elements. Most of the current research on the pathology of ARHL focuses on oxidative damage, mitochondrial dysfunction, inflammation, cochlear blood flow, ion homeostasis, etc. In TCM, herbs belonging to the kidney, lung, and liver meridians exhibit good hearing protection. Seven herbs belonging to the kidney meridian, 9 belonging to the lung meridian, and 4 belonging to the liver meridian were ultimately retrieved in this review, such as Polygonum multiflorum Thunb., Panax ginseng C.A. Mey, and Pueraria lobata (Willd.) Ohwi. Their active compounds, 2,3,4',5-Tetrahydroxystilbene-2-O-D-glucoside, ginsenoside Rb1, and puerarin, may act as the molecular substance for their anti-ARHL efficacy, and show anti-oxidative, neuroprotective, anti-inflammatory, anti-apoptotic, or mitochondrial protective effects. Conclusion Anti-oxidants, modulators of mitochondrial function, anti-inflammation agents, vasodilators, K+ channel openers, Ca2+ channel blockers, JNK inhibitors, and nerve growth factors/neurotrophic factors all contribute to hearing protection, and herbs are an important source of potential anti-ARHL drugs.

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“…Studies by Benkafadar et al (2019) show that EUK-207, a synthetic superoxide dismutase/catalase mimetic, reduced hair cell degeneration and age-related hearing loss in senescence-accelerated mouse-prone 8 (SAMP8) mice. Serra et al (2022) believe that although the antioxidant melatonin cannot completely prevent presbycusis, it can delay its occurrence. Aspirin displays anti-inflammatory and antioxidant properties, and studies have shown that it can effectively reduce hearing loss in aged mice ( Cazals, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Progress on mechanisms of age-related hearing loss

Yang,

Zhao,

Chai

et al. 2023

Front. Neurosci.

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Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly people worldwide. It typically presents as progressive, irreversible, and usually affects the high frequencies of hearing, with a tremendous impact on the quality of life. Presbycusis is a complex multidimensional disorder, in addition to aging, multiple factors including exposure to noise, or ototoxic agents, genetic susceptibility, metabolic diseases and lifestyle can influence the onset and severity of presbycusis. With the aging of the body, its ability to clean up deleterious substances produced in the metabolic process is weakened, and the self-protection and repair function of the body is reduced, which in turn leads to irreversible damage to the cochlear tissue, resulting in the occurrence of presbycusis. Presently, oxidative stress (OS), mitochondrial DNA damage, low-grade inflammation, decreased immune function and stem cell depletion have been demonstrated to play a critical role in developing presbycusis. The purpose of this review is to illuminate the various mechanisms underlying this age-related hearing loss, with the goal of advancing our understanding, prevention, and treatment of presbycusis.

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Melatonin prevents age-related hearing loss in the murin experimental model

Cited by 3 publications

References 24 publications

Reassessment of oxidative stress in idiopathic sudden hearing loss and preliminary exploration of the effect of physiological concentration of melatonin on prognosis

Reassessment of oxidative stress in idiopathic sudden hearing loss and preliminary exploration of the effect of physiological concentration of melatonin on prognosis

Age-related hearing loss and its potential drug candidates: a systematic review

Progress on mechanisms of age-related hearing loss

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