Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer

Trevisani, Lorenzo Fernandes Moça; Kulcsar, Isabelle Fernandes; Leite, Ana Kober Nogueira; Kulcsar, Marco Aurélio Vamondes; Lima, Gabrielle Gimenes; Dedivitis, Rogério Aparecido; Kowalski, Luiz Paulo; Matos, Leandro Luongo de

doi:10.1016/j.bjorl.2021.11.003

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…The ratio of Hb to RDW (HRR) is a convenient prognostic marker for small cell lung cancer (SCLC), non‐small cell lung cancer (NSCLC), and pulmonary large cell neuroendocrine carcinoma (PLCNEC) (Zhao et al, 2022). The combination of RDW, weight loss, and the metastatic lymph nodes were risk factors for the poor survival of patients with advanced oral cancer independent of other clinical and pathological characteristics (Trevisani et al, 2021). Although shorter overall survival and disease‐free survival are associated with Hb ≤ 12.3 g/dL, hematocrit ≤ 38.5%, neutrophil–lymphocyte ratio > 2.9, platelet–lymphocyte ratio > 184.9, and higher fasting glucose level, (Mota et al, 2022) the increased RDW‐to‐albumin ratio is independently associated with increased all‐cause mortality in cancer patients (Lu et al, 2022).…”

Section: The Application Of Rdw In the Diagnosis Of Nonanemic Diseasesmentioning

confidence: 99%

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Yang

Wang

Gao

et al. 2023

Cell Biology International

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Many indicators, including red cell distribution width (RDW) and iron metabolism, are sensitive to a variety of risk factors, and are associated with the pathological alterations and disease onset. RDW reflects the degree of heterogeneous volumes of peripheral red blood cells (RBCs). It has been well‐known that increased RDW indicates iron deficiency anemia, hemolytic anemia, ineffective erythropoiesis, and shorten lifespan of RBCs. Increased RDW is also prevalent in various non‐anemic pathological conditions and diseases. We here review the factors affecting RDW, particularly disordered iron metabolism, chronic inflammation, and oxidative stress, and recapitulate the interplays among these factors. Furthermore, we review the application of increased RDW together with disordered iron homeostasis and the deregulations of hepcidin expression and ferritin levels in the diagnoses and prognosis of anemic and nonanemic diseases. RDW is inexpensive and readily available and may be valuable in adding to the diagnosis and monitoring of many pathological conditions. RDW combined with other indicators, for example, hepcidin and ferritin levels, should be utilized more frequently in clinical practice.

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Section: The Application Of Rdw In the Diagnosis Of Nonanemic Diseasesmentioning

confidence: 99%

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Yang

Wang

Gao

et al. 2023

Cell Biology International

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Management of Older Patients with Head and Neck Cancer: A Comprehensive Review

et al. 2023

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Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma

Trevisani,

Kulcsar,

Kulcsar

et al. 2023

Cancers

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Introduction: Oral squamous cell carcinoma (OSCC) remains a significant public health concern. The variables utilized to determine appropriate treatment for this disease also represent its most unfavorable prognostic factors, with these parameters solely determined by the neoplasm and its behavior. However, a lack of well-established indices is evident in the literature that specifically relate to the patient and indicate a worse prognosis. Objective: To assess the prognostic impact of hematological indices in patients with OSCC. Methods: This retrospective cohort study included patients with oral squamous cell carcinoma (OSCC) who underwent curative-intent treatment. Treatment encompassed surgery, followed by adjuvant therapy, as necessary. Laboratory tests were conducted immediately prior to surgery, and demographic information was obtained from medical records. Results: The cohort comprised 600 patients, with 73.5% being male subjects. Adjuvant treatment was recommended for 60.3% of patients. Throughout the follow-up period, 48.8% of participants died. Univariate analysis indicated that perineural invasion, angiolymphatic invasion, pT4 tumors, lymph node metastases, extranodal extravasation, RDW > 14.3%, NLR (neutrophil–lymphocyte ratio) > 3.38, PLR (platelet–lymphocyte ratio) > 167.3, and SII (systemic inflammatory/immune response index) > 416.1 were factors associated with increased mortality. These threshold values were established through ROC curve analysis. In the multivariate analysis, angiolymphatic invasion (HR = 1.43; 95% CI: 1.076–1.925; p = 0.014), pT4a/b tumors (HR = 1.761; 95% CI: 1.327–2.337; p < 0.001), extranodal extravasation (HR = 1.420; 95% CI: 1.047–1.926; p = 0.024), and RDW (HR = 1.541; 95% CI: 1.153–2.056; p = 0.003) were identified as independent risk factors for decreased overall survival. Conclusions: RDW > 14.3% was proven to be a reliable parameter for assessing overall survival in patients with OSCC. Further studies are required to evaluate the clinical applicability of other hematological indices.

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Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer

Cited by 3 publications

References 41 publications

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Management of Older Patients with Head and Neck Cancer: A Comprehensive Review

Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma

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