The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx

Şahin, Akın; Enver, Necati; Ercetin, Selim; Cinel, Zeliha Leyla; Batman, Abdullah Çağlar

doi:10.1016/j.bjorl.2021.05.009

Cited by 4 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, there is no reliable prognostic marker for OVCA patients hence the urgent need to discover novel markers with significant prognostic utility. Previous studies have demonstrated that pGSN is a useful prognostic marker for OVCA, but not for osteosarcoma and prostate, colon, and head and neck cancers [ 51 , 106 , 107 , 108 ]. In OVCA, multivariate Cox regression analysis showed that pGSN is a remarkable predictor of progression-free survival (PFS) [ 95 ].…”

Section: Clinical Significance Of Pgsnmentioning

confidence: 99%

Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance

Onuma

Asare-Werehene

Yoshida

et al. 2022

Cells

View full text Add to dashboard Cite

Ovarian Cancer (OVCA) is the most fatal gynecologic cancer and has a 5-year survival rate less than 45%. This is mainly due to late diagnosis and drug resistance. Overexpression of plasma gelsolin (pGSN) is key contributing factor to OVCA chemoresistance and immunosuppression. Gelsolin (GSN) is a multifunctional protein that regulates the activity of actin filaments by cleavage, capping, and nucleation. Generally, it plays an important role in cytoskeletal remodeling. GSN has three isoforms: cytosolic GSN, plasma GSN (pGSN), and gelsolin-3. Exosomes containing pGSN are released and contribute to the progression of OVCA. This review describes how pGSN overexpression inhibits chemotherapy-induced apoptosis and triggers positive feedback loops of pGSN expression. It also describes the mechanisms by which exosomal pGSN promotes apoptosis and dysfunction in tumor-killing immune cells. A discussion on the potential of pGSN as a prognostic, diagnostic, and therapeutic marker is also presented herein.

show abstract

Section: Clinical Significance Of Pgsnmentioning

confidence: 99%

Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance

Onuma

Asare-Werehene

Yoshida

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…According to relevant data, the mortality rate of malignant tumors has increased by 83.1% compared with the mid-1970s, and the incidence rate of tumors has increased at a rate of 3%–5% per year ( Asahi et al, 2018 ; Li et al, 2020 ; Ohashi et al, 2022 ; Hosny et al, 2023 ). Laryngeal carcinoma (LC) is the second most common malignant tumor of the head and neck, and diseases such as atypical hyperplasia of the larynx, leukoplakia of the vocal cords, and papilloma are prone to transform into laryngeal cancer ( Wiegand et al, 2020 ; Li and Cheng, 2021 ; Sahin et al, 2022 ; Teng et al, 2022 ). The 5-year relative survival rate for patients with LC varies widely according to tumor site and stage.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive detection of CYFRA21-1 with a SERS sensing platform based on the MBs enrichment strategy and antibody-DNA-mediated CHA amplification

Bao

Wang

Liu

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Laryngeal carcinoma (LC) is the second most common malignant tumor of the head and neck. Due to its insidious nature, most patients have developed to the middle and late stages by the time they are diagnosed, missing the best treatment period. Thus, early detection, diagnosis and treatment are crucial to improve the prognosis of LC and enhance the quality of life of patients. In this study, a surface-enhanced Raman (SERS) sensing platform was developed by combining the magnetic beads (MBs) enrichment strategy and the antibody-DNA-mediated catalytic hairpin self-assembly (CHA) signal amplification technology. 4-Mercaptobenzoic acid (4-MBA) and hairpin DNA 1 (hpDNA1) were modified onto the surface of gold nanobipyramids (GNBPs) as SERS nanotags. Hairpin DNA 2 (hpDNA2) modified MBs were used as capture nanoprobes. Under the action of CHA and magnet-induced MBs enrichment, GNBPs can be assembled on the surface of MBs, forming high-density “hot spots” for the SERS signal enhancement. The results showed that the SERS sensing platform has the advantages of high sensitivity, high specificity and high reproducibility, with the limit of detection (LOD) low to pg/mL level. The expression level of CYFRA21-1 in serum of LC patients and healthy controls was successfully detected by the SERS sensing platform. The accuracy of the SERS results was verified by enzyme linked immunosorbent assay (ELISA). Therefore, this SERS sensor can be used for the detection of CYFRA21-1 in serum, providing a simple and reliable new method for the early diagnosis of LC.

show abstract

Gelsolin and Rac1 Cytoskeleton Protein Microarray Biomarkers in Colon Cancer Metastasis

Çelik

Sapmaz²,

Kılıç³

et al. 2023

Indian J Surg

View full text Add to dashboard Cite

The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx

Cited by 4 publications

References 30 publications

Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance

Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance

Highly sensitive detection of CYFRA21-1 with a SERS sensing platform based on the MBs enrichment strategy and antibody-DNA-mediated CHA amplification

Gelsolin and Rac1 Cytoskeleton Protein Microarray Biomarkers in Colon Cancer Metastasis

Contact Info

Product

Resources

About