Impact of changing classification systems on prevalence and frequency distribution of odontogenic tumors in tertiary care center of Nagpur

Kaur, Harpreet; Gosavi, Suchitra; Hazarey, Vinay K.; Gupta, Vandana; Bhadauria, Upendra Singh; Kherde, Pooja

doi:10.1016/j.bjorl.2021.02.006

Cited by 5 publications

(5 citation statements)

References 43 publications

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“…The unicystic ameloblastoma was the most prevalent histopathologic pattern reported by Gill et al with a mean age of 25.9 years, which was lower than the patients with solid/multicystic ameloblastoma, who had a mean age of 33.2 years (Gill et al, 2011). Similarly, unicystic pattern was more frequently reported in the study sample of Chawla et al, (2013) Regardless of the fact that desmoplastic and peripheral ameloblastoma was generally considered to be rare (Chae et al, 2015;Hendra et al, 2020;Intapa, 2017), eleven of the included studies found desmoplastic variants (Anila K et al, 2021;Effiom et al, 2018;Gill S et al, 2011;Kadashetti V et al, 2014;Kaur et al, 2021;Mullapudi et al, 2011;Pandiar et al, 2015;Selvamani et al, 2014;Varkhede et al, 2011) and peripheral ameloblastoma in six studies (Kiruthika et al, 2021;Krishnapillai et al, 2010;Page et al, 2021;Pandiar et al, 2015;Varkhede et al, 2011).…”

Section: Histopathological Appearancementioning

confidence: 87%

“…Proliferating odontogenic epithelial cells are organized in islands in the follicular type, whereas epithelial cells are structured in continuous anastomosing strands in the plexiform type. Other histologic variants include granular, acanthomatous, desmoplastic and basal cell (Anila et al, 2021;Bansal et al, 2015;Effiom et al, 2018;Gill et al, 2011;Gotur et al, 2017;Kadashetti et al, 2014;Kaur et al, 2021;Pandiar et al, 2015;Selvamani et al, 2014;Varkhede et al, 2011). The unicystic ameloblastoma was the most prevalent histopathologic pattern reported by Gill et al with a mean age of 25.9 years, which was lower than the patients with solid/multicystic ameloblastoma, who had a mean age of 33.2 years (Gill et al, 2011).…”

Section: Histopathological Appearancementioning

confidence: 94%

“…Thirty-three articles were excluded then, as they did not fit our inclusion criteria. For the final review, a total of 27 studies were considered (Ahire et al, 2018;Anila et al, 2021;Bansal et al, 2015;Bhagwat et al, 2017;Deepa et al, 2016;Deepthi et al, 2016;Ebenezer et al, 2010;Gill et al, 2011;Gotur et al, 2017;Kadashetti et al, 2014;Kaur et al, 2021;Kiruthika et al, 2021;Krishnapillai et al, 2010;Mehngi et al, 2018;Mullapudi et al, 2011;Nalabolu et al, 2017;Nazir et al, 2019;Page et al, 2021;Pandiar et al, 2015;Parashar et al, 2018;Saxena et al, 2012;Selvamani et al, 2014;Sharma et al, 2017;Singhal et al, 2013;Syed et al, 2019;Varkhede et al, 2011Varkhede et al, ) [, #2038. Figure 1 illustrates the study sequence.…”

Section: Study Selectionmentioning

confidence: 99%

“…Selvmani et al, (2014) and Nazir and Usman (2019) concluded that mandibular predisposition was present in 96.8% and 92.7% of their samples respectively. The mandible to maxilla ratio has been reported to be as high as 24.1:1 by Kaur et al, (2021) (Table 2).…”

Section: Anatomic Site Of the Tumormentioning

confidence: 99%

“…All of the documented malignant tumors were mostly detected in the mandible and mostly appeared after the sixth decade (Kaur et al, 2021) cited malignant lesions in the included studies were ameloblastic carcinoma and ameloblastic fibrosarcoma/ odontogenic sarcoma (Gill et al, 2011;Gotur et al, 2017;Kiruthika et al, 2021;Selvamani et al, 2014). Table 4 shows other malignant lesions that have been identified in the review.…”

Section: Malignant Transformationmentioning

confidence: 99%

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Prevalence and Epidemiological Profile of Ameloblastoma in India: A Systematic Review and Meta-Analyses

Yoithapprabhunath

Kumar

Janardhanam

et al. 2022

Asian Pac J Cancer Prev

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Introduction: Ameloblastoma is regarded as the second most prevalent odontogenic tumor in the light of its prevalence, clinical characteristics, greater incidence of tumor recurrence, and therapeutic challenges. The aim of this systematic review was to establish the prevalence of ameloblastoma in the Indian subcontinent and to establish a national epidemiologic profile for these lesions. Material and Methods: A systematic review was undertaken based on the PRISMA guidelines in search of epidemiologic studies concerning odontogenic tumors and ameloblastoma that are listed by PubMed, EBSCO, and Google Scholar embracing the period from January 2010 to December 2021, to evaluate the prevalence rate in India. A total of 277 publications were retrieved, of which 27 articles were selected, based on the World Health Organization classification of odontogenic tumors. Results: The affected individuals were on average in the third decade of life, with a higher male predominance. The majority of the tumors were multilocular radiolucencies in the posterior mandible, with follicular and plexiform histopathological features. The most common type of malignant lesion is ameloblastic carcinoma. Over 60% of follicular ameloblastoma recurred more frequently than the other types of ameloblastoma. Conclusion: The systematic study indicates a slight male predisposition to ameloblastoma, with a peak incidence in the third decade of life and the mandible as the preferred anatomical site. The solid/multicystic ameloblastoma is the most prevalent histopathologic pattern. More epidemiological research on the prevalence rate of ameloblastoma is required, particularly in India, in an effort to accurately determine the national epidemiological profile of ameloblastoma.

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Section: Histopathological Appearancementioning

confidence: 87%

Section: Histopathological Appearancementioning

confidence: 94%

Section: Study Selectionmentioning

confidence: 99%

Section: Anatomic Site Of the Tumormentioning

confidence: 99%

Section: Malignant Transformationmentioning

confidence: 99%

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Prevalence and Epidemiological Profile of Ameloblastoma in India: A Systematic Review and Meta-Analyses

Yoithapprabhunath

Kumar

Janardhanam

et al. 2022

Asian Pac J Cancer Prev

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Targeted therapies in ameloblastomas and amelobastic carcinoma—A systematic review

Bologna‐Molina,

Schuch,

Magliocca

et al. 2024

Oral Diseases

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Targeted therapy has the potential to be used in the neoadjuvant setting for odontogenic tumors, reducing the morbidities associated with major surgery. In this regard, the aim of this study was to summarize the current evidence on the different forms of targeted therapy, effectiveness, and drawbacks of this course of treatment. Four databases were searched electronically without regard to publication date or language. Grey literature searches and manual searches were also undertaken. Publications with sufficient clinical data on targeted therapy for odontogenic tumors were required to meet the criteria for eligibility. The analysis of the data was descriptive. A total of 15 papers comprising 17 cases (15 ameloblastomas and 2 ameloblastic carcinomas) were included. Numerous mutations were found, with BRAF V600E being most common. Dabrafenib was the most utilized drug in targeted therapy. Except for one case, the treatment reduced the size of the lesion (16/17 cases), showing promise. Most of the adverse events recorded were mild, such as skin issues, voice changes, abnormal hair texture, dry eyes, and systemic symptoms (e.g., fatigue, joint pain, and nausea). It is possible to reach the conclusion that targeted therapy for ameloblastoma and ameloblastic carcinoma may be a useful treatment strategy, based on the findings of the included studies.

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Frequency and Demographic Analysis of Odontogenic Tumors in Three Tertiary Institutions: An 11-Year Retrospective Study

Almazyad,

Alamro,

Almadan

et al. 2024

Diagnostics

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Odontogenic tumors (OTs) are distinct conditions that develop in the jawbones, exhibiting diverse histopathological features and variable clinical behaviors. Unfortunately, the literature on this subject in Saudi Arabia remains sparse, indicating a pressing need for more comprehensive data concerning the frequency, demographics, treatment modalities, and outcomes of OTs. Objectives: The study aims to evaluate the frequency, demographic features, treatment, and outcomes of OTs across three tertiary medical centers. Methods and Material: OT cases were identified in King Abdulaziz Medical City (KAMC), King Fahad Medical City (KFMC), and Prince Sultan Military Medical City (PSMMC) from January 2010 to December 2021. Results: Ninety-two OT cases were identified from the anatomical pathology laboratories of three tertiary hospitals. KFMC contributed the highest number of cases (43.5%), followed by KAMC (30.4%) and PSMMC (26.1%). The median age of OT patients was 29 years (range: 5–83), with males representing more than half of the patients (56.5%). The mandible was the most frequent site of OT occurrence (72.5%), with ameloblastoma being the predominant OT (63.0%), followed by odontoma (19.5%). Among the treatment modalities, bone resection was employed the most (51.0%), followed by enucleation (25.6%). Notably, 11.5% of OT cases with available follow-up data exhibited recurrence, with ameloblastoma accounting for eight recurrent cases. Conclusions: Although OTs are relatively common in the jaws, they are rare in anatomical pathology laboratories and the general population. This study contributes valuable insights into the epidemiology characteristics, treatment trends, and recurrence rates of OTs in Saudi Arabia.

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Impact of changing classification systems on prevalence and frequency distribution of odontogenic tumors in tertiary care center of Nagpur

Cited by 5 publications

References 43 publications

Prevalence and Epidemiological Profile of Ameloblastoma in India: A Systematic Review and Meta-Analyses

Prevalence and Epidemiological Profile of Ameloblastoma in India: A Systematic Review and Meta-Analyses

Targeted therapies in ameloblastomas and amelobastic carcinoma—A systematic review

Frequency and Demographic Analysis of Odontogenic Tumors in Three Tertiary Institutions: An 11-Year Retrospective Study

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