Prevalence and Epidemiological Profile of Ameloblastoma in India: A Systematic Review and Meta-Analyses

Abstract

Introduction: Ameloblastoma is regarded as the second most prevalent odontogenic tumor in the light of its prevalence, clinical characteristics, greater incidence of tumor recurrence, and therapeutic challenges. The aim of this systematic review was to establish the prevalence of ameloblastoma in the Indian subcontinent and to establish a national epidemiologic profile for these lesions. Material and Methods: A systematic review was undertaken based on the PRISMA guidelines in search of epidemiologic studies concerning odontogenic tumors and ameloblastoma that are listed by PubMed, EBSCO, and Google Scholar embracing the period from January 2010 to December 2021, to evaluate the prevalence rate in India. A total of 277 publications were retrieved, of which 27 articles were selected, based on the World Health Organization classification of odontogenic tumors. Results: The affected individuals were on average in the third decade of life, with a higher male predominance. The majority of the tumors were multilocular radiolucencies in the posterior mandible, with follicular and plexiform histopathological features. The most common type of malignant lesion is ameloblastic carcinoma. Over 60% of follicular ameloblastoma recurred more frequently than the other types of ameloblastoma. Conclusion: The systematic study indicates a slight male predisposition to ameloblastoma, with a peak incidence in the third decade of life and the mandible as the preferred anatomical site. The solid/multicystic ameloblastoma is the most prevalent histopathologic pattern. More epidemiological research on the prevalence rate of ameloblastoma is required, particularly in India, in an effort to accurately determine the national epidemiological profile of ameloblastoma.

Surgical management of mandibular ameloblastoma and immediate reconstruction with iliac crest and costochondrial bone grafts: A case report

“…Complete surgical removal of the lesion, including the extension of a safe margin with at least 1 cm to 2 cm thickness to reduce the risk of recurrence of the tumor, and restoration of function and appearance are the main goals of treatment. A tumor excision is ideally followed by reconstruction with a bone graft or flap and dental prostheses [ 10 , 11 ]. Reconstruction is easier if done earlier due to a lack of scarring or contracture, and it can be advantageous psychologically [ 12 ].…”

Ameloblastoma

“…This illness is far more common in underdeveloped nations, where the chance of recurrence is greater. 8 Ameloblastoma occurs around five times more frequently in the lower jaw (mandible) than in the upper jaw (maxilla). 4 There is no predilection for sex, and it is most common in the third and fourth decades of life.…”

Ameloblatoma: An aggressive odontogenic neoplasm with altered vickers and gorlin criteria

“…1 Microscopically, follicular and plexiform patterns along with granular, acanthomatous, desmoplastic and basal cell are observed. 2 Ameloblastoma are usually diagnosed based on the Vickers and Gorlin (V and G) criteria featuring the presence of hyperchromatism of basal cell nuclei, basal cell palisading, reversal of polarity and cytoplasmic vacuolization with intercellular spacing of lining epithelium. 3 However, Gardener DG highlighted that not all ameloblastoma show classic V and G criteria, cytoplasmic vacuolations and reverse polarity may not be present in all histological varieties of ameloblastoma.…”