Hearing of neonates without risk indicators for hearing loss and use of antimalarial drugs during pregnancy: a historical cohort study in the Northern Region of Brazil

Patatt, Fernanda Soares Aurélio; Sampaio, André Luiz Lopes; Tauil, Pedro Luíz; Oliveira, Carlos Augusto Costa Pires de

doi:10.1016/j.bjorl.2019.06.005

Cited by 3 publications

(3 citation statements)

References 32 publications

(55 reference statements)

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“…Also, when administered during pregnancy, chloroquine is capable of crossing the placental barrier causing lesions in the inner ear of the fetuses. In Aurelio et al [29] and Silva et al [30] studies, the prevalence of hearing loss in children whose mothers used chloroquine during pregnancy ranged from 3% to 6.7%, with a 5 times higher risk of developing SNHL. However, Patatt et al [31] and Borba et al [18] have not shown this relationship in their studies.…”

Section: Discussionmentioning

confidence: 97%

A Systematic Review of the Auditory and Vestibular Effects of Chloroquine and Hydroxychloroquine

Costa¹

2022

JCO

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Introduction: chloroquine and hydroxychloroquine are antimalarial drugs that, although normally well tolerated, have side effects, such as gastrointestinal intolerance, retinopathy and arrhythmias. There are reports of sensorineural hearing loss, tinnitus and vertigo related to the two drugs. However, the ototoxic potential of these medications is routinely not researched. With the significant increase in the use of these drugs in the face of the COVID-19 pandemic, the study of their ototoxic effects becomes even more important. Objective: to evaluate the ototoxic potential of chloroquine and hydroxychloroquine through a systematic review of the articles available in the literature. Method: a search for articles published until April 2020 was carried out in the PubMed, Web of Science, SciELO and Lilacs databases, with descriptors registered in MeSH. Articles that associated the use of chloroquine or hydroxychloroquine with auditory and / or vestibular effects were included. Result: the search resulted in 161 articles, of which 18 met the inclusion criteria. Of these, 16 demonstrated ototoxic effects of chloroquine and / or hydroxychloroquine. Chloroquine was considered the second main drug involved in ototoxicity in 2 studies. A 5-fold higher risk of hearing loss has also been reported in neonates whose mothers used chloroquine during pregnancy. Conclusion: studies have shown that chloroquine and hydroxychloroquine have ototoxic action, which may initially go unnoticed if there is no active investigation. The significant increase in the use of chloroquine and hydroxychloroquine in the face of the COVID-19 pandemic may represent an escalation in ototoxicity, which should not be neglected.

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Section: Discussionmentioning

confidence: 97%

A Systematic Review of the Auditory and Vestibular Effects of Chloroquine and Hydroxychloroquine

Costa¹

2022

JCO

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“…En ese sentido, las complicaciones fetales incluyen aborto espontáneo, feto de bajo peso al nacer (menor a 2500 gramos) producto de la restricción del crecimiento intrauterino, y parto pretérmino (menos de 37 semanas de gestación) (10,(64)(65)(66)(67)(68)(69). La parasitemia materna periférica también se encuentra asociada con efectos adversos en el infante, incluyendo anemia, mortalidad neonatal e infantil, y malaria congénita.…”

Section: Manifestaciones Clínicas Y Complicaciones Maternofetalesunclassified

Malaria asociada al embarazo: revisión narrativa

Núñez-Troconis¹,

Ruiz²,

Núñez³

2023

RSOGV

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Malaria infections increase the risk of complications in the mother-fetus binomial. In Venezuela, the casuistry of this vulnerable group has not been updated in recent years. The objective of this narrative review was to comprehensively describe what pregnancy-associated malaria is and its maternal, fetal and neonatal effects; trying to answer the following research question. All forms of pregnancy-associated malaria, including gestational, placental and congenital malaria, cause maternal-fetal and neonatal alterations that, if they progress, could lead to the death of this binomial. Physiopathology and immunopathology can explain the symptoms of pregnant women and the fetus, as well as their complications; depending on the parasitic form affecting. There are new updates in the diagnosis, prevention and treatment of this entity.

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“…63 In this sense, fetal complications include miscarriage, fetus with low birthweight (less than 2500grams) resulting from intrauterine growth restriction, and preterm delivery (less than 37 weeks gestation). 10,[64][65][66][67][68][69] Peripheral maternal parasitemia is also associated with adverse effects on infants, including anemia, neonatal and infant mortality, and congenital malaria. Symptoms of the latter tend to appear after 10 to 30 days post-labor and include fever, hepatosplenomegaly, hemolytic anemia, thrombocytopenia, and food intolerance.…”

Section: Clinical Manifestations and Maternal-fetal Complicationsmentioning

confidence: 99%

Malaria and pregnancy: a Venezuelan approach. Review article

Ruiz¹,

Núñez²,

Martín-Castelli³

et al. 2022

OGIJ

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Aim: to review and describe exhaustively the implications of malaria in pregnancy, including its maternal, fetal, and neonatal clinical manifestations and effects; immunopathology and pathophysiology; advancements in its diagnostics, histopathology, and treatment options; and epidemiology, particularly in Venezuela, a country where its data is almost non-existent. Methods: the information used to write this manuscript was obtained during a three-month period, between June and September 2022, from specialized literature, written in English and Spanish, related to malaria associated with pregnancy, mainly published during the last five years, using journals found in the most relevant medical digital archives, including PubMed, SciELO, Elsevier, Google Scholar, Latindex, and Cochrane Plus. Among the keywords used for obtaining this updated information were malaria; malaria in pregnancy; gestational malaria; placental malaria; congenital malaria. Results: all the clinical forms related to malaria in pregnancy, including gestational, placental, and congenital malaria, can cause maternal-fetal alterations, that, in case of progressing, could lead to the death of this binomial. Their pathophysiology and immunopathology can explain the gestational and fetal symptomatology, as well as their complications, depending on the parasite form that affected them. There are new updates regarding the diagnostics, prevention, and treatment of this medical entity. Conclusion: it is imperative to exalt the relevance of studying this disease in pregnant patients, especially in the Venezuelan topography, a focus of infection with a plethora of cases of said entity, whose lack of updated epidemiological data, regarding its prevalence and incidence, is profoundly preoccupying. Pregnant patients are not only one of the most vulnerable risk groups of this parasitosis, but also have the capacity of duplicating the risk of infecting the fetus.

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Hearing of neonates without risk indicators for hearing loss and use of antimalarial drugs during pregnancy: a historical cohort study in the Northern Region of Brazil

Cited by 3 publications

References 32 publications

A Systematic Review of the Auditory and Vestibular Effects of Chloroquine and Hydroxychloroquine

A Systematic Review of the Auditory and Vestibular Effects of Chloroquine and Hydroxychloroquine

Malaria asociada al embarazo: revisión narrativa

Malaria and pregnancy: a Venezuelan approach. Review article

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