Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus

Ekinci, Adnan; Kamaşak, Kaan

doi:10.1016/j.bjorl.2019.01.009

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…According to a study using total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON), which are oxidative stress markers traditionally used as indicators of oxidant/antioxidant balance, TAS and PON of patients with tinnitus were lower than those of the control group, but TOS and OSI were higher [ 108 ]. Although the number of subjects was small, the study of idiopathic tinnitus with normal hearing also showed higher TOS and OSI in patients with tinnitus than that in the control group, but there was no difference in TAS [ 109 ].…”

Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

“…Prolidase, which belongs to the family of hydrolases and is involved in collagen degradation and synthesis, has been demonstrated as a causative factor in various diseases, such as nasal polyps and asthma [ 116 , 117 ]. In a study of 25 patients with chronic tinnitus with normal hearing, low serum prolidase enzyme activity was noted in patients with tinnitus [ 109 ]. This is considered to be evidence of oxidative stress in tinnitus, considering the relationship between proline and oxidative stress observed in animal studies.…”

Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

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Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Kang

Kim

Park

et al. 2021

IJMS

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Tinnitus is associated with increased social costs and reduced quality of life through sleep disorders or psychological distress. The pathophysiology of chronic subjective tinnitus, which accounts for most tinnitus, has not been clearly elucidated. This is because chronic subjective tinnitus is difficult to evaluate objectively, and there are no objective markers that represent the diagnosis or therapeutic effect of tinnitus. Based on the results of studies on patients with chronic subjective tinnitus, objective and measurable biomarkers that help to identify the pathophysiology of tinnitus have been summarized. A total of 271 studies in PubMed, 303 in EMBASE, and 45 in Cochrane Library were found on biomarkers related to chronic subjective tinnitus published until April 2021. Duplicate articles, articles not written in English, review articles, case reports, and articles that did not match our topic were excluded. A total of 49 studies were included. Three specimens, including blood, saliva, and urine, and a total of 58 biomarkers were used as indicators for diagnosis, evaluation, prognosis, and therapeutic effectiveness of tinnitus. Biomarkers were classified into eight categories comprising metabolic, hemostatic, inflammatory, endocrine, immunological, neurologic, and oxidative parameters. Biomarkers can help in the diagnosis, measure the severity, predict prognosis, and treatment outcome of tinnitus.

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Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Kang

Kim

Park

et al. 2021

IJMS

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“…Vücutta üretilen ROS'ların pek çok dejeneratif hastalığa neden olduğu bilinmektedir (11). Sürekli olarak ROS ataklarıyla karşı karşıya olan organizma (12), bu duruma karşı koymak için çeşitli antioksidan savunma mekanizmaları geliştirir (13). Nonoksidanlar ROS'un etkilerini minimalize ederek nötrleştirilmesini sağlar (14).…”

Section: Discussionunclassified

İnfantlarda Serum Prolidaz Aktivitesinin Oksidatif ve Nonoksidatif Durumda Gelişimsel Kalça Displazi Hastalığı ile İlişkisi

Vatansever

Çetin

Altay

et al. 2021

Harran Üniversitesi Tıp Fakültesi Dergisi

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Öz.Amaç: Gelişimsel kalça displazili (GKD) hastaların tedavi sürecinde serum prolidaz aktivitesinin oksidatifnonoksidatif durumlarda takip edilerek, tedavi ve takip parametresi olarak serum prolidaz aktivitesinin kullanımını araştırmayı amaçladık. Materyal ve Metod: Prospektif olarak gerçekleştirilen bu çalışma, 0-6 ay arasındaki 30 GKD'li bebek ve 0-6 ay arasındaki 30 sağlıklı bebekten oluşan iki grubu içermektedir. Hasta grubunda yer alan bebeklerden 3 kez, kontrol grubundaki bebeklerden 1 kez olmak üzere kan örnekleri alındı. Bu kanlarda total antioksidan stres (TAS), total oksidatif stres (TOS), oksidatif stres indeksi (OSI) ve prolidaz enzim aktvitesine bakıldı. Sonuçlar kendi aralarında karşılaştırıldı. Bulgular: Tedaviye başlamadan önce hasta ve sağlıklı bebeklerden alınan kanlarda bakılan TOS, OSI ve serum prolidaz seviyelerinin kontrol grubundaki bebeklere kıyasla hasta grubunda yer alan bebeklerde anlamlı bir şekilde daha yüksek olduğu tespit edildi. TAS seviyesinin ise kontrol grubuna oranla düşük olduğu tespit edildi. Hasta bebeklere uygulanan 6 haftalık pavlik bandaj tedavisinin ardından hasta bebeklerin TAS, TOS, OSI ve serum prolidaz seviyelerinde istatistiksel olarak kontrol grubu ile uyumlu olacak şekilde düzelme gözlemlendi. Sonuç: Artan TOS ve OSI seviyelerinin bu hastalık bağlamında oksidatif strese neden olduğu ve dejeneratif hastalıklarda görüldüğü gibi artmış prolidaz aktivitesinin artmış kolajen metabolizmasına neden olduğu sonucuna varılmıştır. GKD şiddetini değerlendirmede ve tedavinin takibinde serum prolidaz aktivitesi ve oksidatif-nonoksidatif durum parametrelerinin yardımcı birer araç olabileceğini söyleyebiliriz.

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“…The cell-specific effects of ROS and the specificity of activators of TPAM1 may explain the relevance of data that correlate oxidative stress with the presence of tinnitus, as documented by the levels of total antioxidant status (TAS), thiols (antioxidant molecules that react with free radicals to prevent oxidative damage), and paraoxonase-1 (PON) activity (an enzyme preventing lipid peroxidation) [38,50,51].…”

Section: The Specific Mechanisms Altering Ohc Sc Structure 711 Oxidat...mentioning

confidence: 99%

The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes

Lazzeri,

Biagioni,

Ferrucci

et al. 2023

IJMS

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Tinnitus is the perception of noise in the absence of acoustic stimulation (phantom noise). In most patients suffering from chronic peripheral tinnitus, an alteration of outer hair cells (OHC) starting from the stereocilia (SC) occurs. This is common following ototoxic drugs, sound-induced ototoxicity, and acoustic degeneration. In all these conditions, altered coupling between the tectorial membrane (TM) and OHC SC is described. The present review analyzes the complex interactions involving OHC and TM. These need to be clarified to understand which mechanisms may underlie the onset of tinnitus and why the neuropathology of chronic degenerative tinnitus is similar, independent of early triggers. In fact, the fine neuropathology of tinnitus features altered mechanisms of mechanic-electrical transduction (MET) at the level of OHC SC. The appropriate coupling between OHC SC and TM strongly depends on autophagy. The involvement of autophagy may encompass degenerative and genetic tinnitus, as well as ototoxic drugs and acoustic trauma. Defective autophagy explains mitochondrial alterations and altered protein handling within OHC and TM. This is relevant for developing novel treatments that stimulate autophagy without carrying the burden of severe side effects. Specific phytochemicals, such as curcumin and berberin, acting as autophagy activators, may mitigate the neuropathology of tinnitus.

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Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus

Cited by 11 publications

References 32 publications

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

İnfantlarda Serum Prolidaz Aktivitesinin Oksidatif ve Nonoksidatif Durumda Gelişimsel Kalça Displazi Hastalığı ile İlişkisi

The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes

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