Is there any association between Helicobacter pylori and otitis media with effusion?

Damghani, Mohammad Ali; Dehghan, E Khaleghi

doi:10.1016/j.bjorl.2018.11.002

Cited by 11 publications

(8 citation statements)

References 17 publications

(20 reference statements)

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“…Although abdominal pain, nausea, vomiting, anorexia, weight loss, or heartburn are commonly encountered in children with H. pylori infection, the clinical picture remains unspecific[ 2 ]. Recent studies have also noted several extra-digestive manifestations such as thrombocytopenia, anemia, eosinophilic esophagitis, or otitis media that might be related to the presence of H. pylori in children[ 3 - 5 ]. Nevertheless, taking into account the difficulties related to performing endoscopic studies in children and therefore the scarcity of information in this age group, a precise cause-effect relationship between these manifestations and H. pylori has been difficult to establish.…”

Section: Introductionmentioning

confidence: 99%

Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

Meliţ

Mărginean

Săsăran

et al. 2021

WJCC

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BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori (H. pylori) infection and increased risk of gastric cancer. AIM To identify the risk factors associated with H. pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children. METHODS We performed a study of 155 children with digestive symptoms, who were divided into two groups according to the histopathological exam: Group 1 – 48 children with H. pylori -induced chronic gastritis, and Group 2 – control group. RESULTS Rural area and poor living conditions were significantly associated with H. pylori chronic gastritis ( P = 0.0042/ P < 0.0001). Both positive immunoglobulin A anti H. pylori and the rapid urease test were significantly associated with H. pylori infection ( P < 0.0001). Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H. pylori chronic gastritis ( P = 0.111/ P = 0.284). We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils ( P = 0.0225/ P = 0.0292). CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation.

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Section: Introductionmentioning

confidence: 99%

Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

Meliţ

Mărginean

Săsăran

et al. 2021

WJCC

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“…It is also known to be active in non-gastrointestinal diseases such as IgA nephropathy 8 . The presence of HP in the middle ear suggests that it may play a role in the pathogenesis of otitis media with effusion 9 .…”

Section: Discussionmentioning

confidence: 99%

Colonization of Helicobacter pylori in Tonsillectomy Materials

Gunizi¹,

Gunizi²

2022

jamp

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To detect the presence of Helicobacter pylori in tonsillar tissue, and to investigate the difference in Helicobacter pylori colonization in patients with tonsillary hypertrophy and chronic tonsillitis. One hundred twenty-two patients underwent tonsillectomy due to chronic tonsillitis. or tonsillary hypertrophy was included in our retrospective study. The tonsillectomy materials of the patients were stained with the Giemsa stain and evaluated under light microscopy. The data obtained in the study were evaluated statistically and results with a p-value of <0.05 were accepted as significant. The mean age of the patients included in the study was 11.9 years. Ninety-three (76.2%) patients were in the pediatric age group, and 29 (23.8%) were adults. Fifty-five (45.1%) patients were female and 67 (54.9) were male. Eighty patients underwent tonsillectomy due to tonsillary hypertrophy and 42 due to chronic tonsillitis. In our study, the presence of Helicobacter pylori was detected in 21 (17.2%) patients. The presence of Helicobacter pylori colonization in patients with chronic tonsillitis and tonsillary hypertrophy indicates that tonsils are an extra-stomach reservoir for Helicobacter pylori.

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“…24 OME presents multifactorial etiology, contemplating both infectious and non-infectious causes. 21 In to infectious causes, bacterial biofilms adhered to the surface of the tympanal respiratory epithelium would be responsible for triggering pro-inflammatory stimuli, culminating in OME. 25 The main bacteria associated with inflammation of the middle ear mucosa are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, cannot rule out adenoiditis and viral causes.…”

Section: Discussionmentioning

confidence: 99%

“…HP is one of the most frequent causes of infection around the world, and by the age of 10, approximately 75% of children will be infected with H. pylori. 21 In this context, the presence of Helicobacter pylori, detected by several diagnostic methods, in middle ear effusions and nasopharynx structures is discussed, raising the hypothesis that the stomach bacterium may also have some role in the pathogenesis of OME.…”

Section: Discussionmentioning

confidence: 99%

A Relação Entre a Patogênese Da Otite Média Efusiva E Helicobacter Pylori Em Crianças: Uma Revisão Integrativa

PEDRO¹,

VEIGA²,

TSUTIDA³

et al. 2021

Publ. Biologicas

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Objective: To discuss the role of Helicobacter pylori (HP) in the pathogenesis of otitis media with effusion (OME) in children in an integrative literature review.Method: Integrative review made in 2020 performed in the following databases: PUBMED and Biblioteca Virtual em Saúde (BVS), which includes MEDLINE, SciELO and LILACS. The descriptors "Helicobacter pylori", "Otitis Media with Effusion", "Child" and "Children" were used. It was found 66 articles, of which duplicates or without relevance to the theme were excluded, leaving 18 to full-text reading. From these, only 16 complied with the research question.Results: A total of 11 articles showed the presence of Helicobacter pylori in middle ear effusion (MEE) and/or biopsy by different methods, especially PCR, used in 12 of the 16 articles. The positivity of the samples varied between 2.9% and 70% in the analyzed studies, but only 6 of them suggested the middle ear of children with otitis media with effusion and the clinical improvement of the disease with alternative treatment for this bacterium. The other studies question the relationship ear, presence of not viable organisms for OME and non-acidic environment for HP. Conclusions:on the etiopathogenesis of otitis media with effusion.

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Is there any association between Helicobacter pylori and otitis media with effusion?

Cited by 11 publications

References 17 publications

Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

Colonization of Helicobacter pylori in Tonsillectomy Materials

A Relação Entre a Patogênese Da Otite Média Efusiva E Helicobacter Pylori Em Crianças: Uma Revisão Integrativa

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