Insulin resistance is associated with Sfrp5 in obstructive sleep apnea

Sun, Shibo; Zhai, Huifen; Mei, Zhu; Wen, Peili; He, Xin; Wang, Haoyan

doi:10.1016/j.bjorl.2018.07.002

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…The relationship between OSA and these factors however remain unclear. Previous studies on adiponectin and apelin levels in OSA patients report conflicting results (21)(22)(23)(24) while other few focusing on chemerin and SFRP5 in OSA patients, have been limited by the absence of multivariate adjustment or a smaller sample size (25,26). Furthermore, the relationship between these adipokines and IMT among OSA patients was not clarified.…”

Section: Introductionmentioning

confidence: 98%

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Song

et al. 2020

Front. Endocrinol.

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Objective: Obstructive sleep apnea (OSA) results in increased carotid intima-media thickness (IMT) and arterial stiffness; however, the association between adipocytokines and IMT/arterial stiffness in OSA patients is unclear. Methods:We enrolled 95 normal weight and overweight, not obese, participants from May 2018 to December 2018 in this study. All subjects underwent a carotid artery ultrasound examination and polysomnography. Blood samples were used to determine serum chemerin, adiponectin, SFRP5, and apelin levels. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient.Stepwise models of multiple linear regression analysis were performed to assess the independent relationships.Result: IMT in OSA patients was significantly higher than in the non-snorers. There were significant differences in the arterial stiffness parameters such as distensibility coefficient (DC), compliance coefficient (CC), and pulse wave velocity (PWV). SFRP5 level was lower in OSA patients than in non-snorers. Adiponectin correlated with CC, DC, and PWV among OSA patients; however, the relationship disappeared after a multivariable adjustment. Age was independently associated with all quantitative IMT and stiffness indices. AHI and minimum oxygen saturation (Mini SaO 2 ) were independently related to arterial stiffness. Conclusion:The quantitative IMT and carotid arterial elasticity were significantly worse among OSA patients. Age was the main independent factor correlated with quantitative IMT and arterial stiffness, and AHI and mini SaO 2 were associated factors. There were no relationships between aforementioned adipocytokines and quantitative IMT/carotid arterial stiffness.

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Section: Introductionmentioning

confidence: 98%

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Song

et al. 2020

Front. Endocrinol.

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“…Accumulating evidence suggests that hypoxia is an important pathogenic factor for diabetes or insulin resistance [71][72][73]. Sestrin2 is important to maintain insulin sensitivity and glucose metabolism through HIF-1α or AMPKdependent autophagic activation [72,74].…”

Section: Sestrin2 and Other Hypoxia-related Diseasesmentioning

confidence: 99%

Sestrin2 in hypoxia and hypoxia-related diseases

et al. 2021

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Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases. Methods: A review was conducted through an electronic search of PubMed and Medline databases. Keywords included Sestrin2, ROS, hypoxia, and hypoxia-related disease. Articles from 2008 to 2021 were mostly included and older ones were not excluded. Results: Sestrin2 is upregulated under various stress conditions, especially hypoxia. Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway. In addition, Sestrin2 is involved in various hypoxia-related diseases, such as cerebral hypoxic disease, myocardial hypoxic disease, hypoxia-related respiratory disease, and diabetes. Discussion: Sestrin2 is involved in various hypoxia-related diseases and maybe a therapeutic target. Furthermore, most studies focus on cerebral and myocardial ischemia reperfusion. More researches on hypoxia-related respiratory diseases, kidney injury, and diabetes are needed in future.

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“…Obstructive sleep apnea (OSA) is characterized by repeated upper airway obstructions [1,2]. This disorder is highly prevalent and has a considerable influence on the morbidity and mortality of the Brazilian population [2,3]. OSA may be associated with the development of type II diabetes mellitus [2].…”

Section: Rbfex Introductionmentioning

confidence: 99%

“…This disorder is highly prevalent and has a considerable influence on the morbidity and mortality of the Brazilian population [2,3]. OSA may be associated with the development of type II diabetes mellitus [2]. It is also a risk factor for systemic arterial hypertension, stroke, depression, insomnia, anxiety, and cardiovascular diseases [1,3].…”

Section: Rbfex Introductionmentioning

confidence: 99%

Relação da apneia obstrutiva do sono com consumo de oxigênio, atividade física e alimentação

Brito¹,

Guimarães

Fernandes³

et al. 2021

Rev Bras Fisiol Exerc

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Objetivo: Avaliar o consumo máximo de oxigênio (VO2máx), nível de atividade física, consumo alimentar e qualidade de vida em pacientes com apneia obstrutiva do sono (AOS). Métodos: Estudo descritivo quali-quantitativo com análise transversal a partir de aplicação de questionários estruturados, realizado em uma clínica privada de Petrolina, PE. A qualidade de vida foi avaliada pelo WHOQOL-bref, o consumo alimentar pelo formulário de marcadores do consumo alimentar que consta no Protocolo do SISVAN e o nível de atividade física pela versão curta do IPAQ. Resultados: Dos 16 pacientes incluídos, 6 não tinham AOS, 4 apresentaram AOS leve, 2 AOS moderada e 4 AOS grave. Sedentarismo foi prevalente em 20% dos pacientes com AOS leve, em 50% dos com AOS moderada e em 75% dos com AOS grave. Consumo alimentar saudável prevaleceu em todos os grupos, com maior consumo de alimentos não saudáveis por pacientes com AOS grave. Foi identificado predomínio de qualidade de vida regular em todos os grupos, necessitando melhorar especialmente o domínio físico de todos eles. Tanto VO2máx quanto o limiar anaeróbico apresentaram valores reduzidos à medida que a gravidade da doença aumentava, sendo menores os valores nos pacientes com a forma mais grave da doença. Conclusão: Foi constatada relação inversa entre AOS mais grave com o VO2máx e os níveis de atividade física dos pacientes analisados. Há um maior consumo de alimentos não saudáveis com má alimentação e comportamento sedentário que constituem importantes fatores de risco para o desenvolvimento e agravamento da doença.

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Insulin resistance is associated with Sfrp5 in obstructive sleep apnea

Cited by 7 publications

References 32 publications

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Sestrin2 in hypoxia and hypoxia-related diseases

Relação da apneia obstrutiva do sono com consumo de oxigênio, atividade física e alimentação

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Insulin resistance is associated with Sfrp5 in obstructive sleep apnea

Cited by 7 publications

References 32 publications

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Sestrin2 in hypoxia and hypoxia-related diseases

Relação da apneia obstrutiva do sono com consumo de oxigênio, atividade fí­sica e alimentação

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Relação da apneia obstrutiva do sono com consumo de oxigênio, atividade física e alimentação