The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats

Özdemir, Doğukan; Özgür, Abdulkadir; Kalkan, Yıldıray; Terzi, Suat; Tümkaya, Levent; Yılmaz, Adnan; Çeliker, Metin; Dursun, Engin

doi:10.1016/j.bjorl.2017.10.009

Cited by 12 publications

(13 citation statements)

References 22 publications

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“…Each group contained eight randomly selected rats. The sample size of the study was determined according to similar studies previously conducted (5,15,16).…”

Section: Experimental Designmentioning

confidence: 99%

Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model

Atalay

Tatar

Dinçer

et al. 2021

Turk Arch Otorhinolaryngol

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Objective: This study aimed to explore whether carvacrol (CV) had a protective effect on paclitaxel-induced ototoxicity from biochemical, functional, and histopathological perspectives.Methods: Forty Wistar albino male rats were randomly separated into five groups of eight rats. Group 1 was the control group, so Paclitaxel or CV was not administered. Group 2 was administered i.p. CV at 25 mg/kg once a week; Group 3, was administered i.p. paclitaxel at 5 mg/kg once a week; Group 4 was administered i.p. paclitaxel at 5 mg/kg followed (30 min later) by CV at 25 mg/kg once a week; and Group 5 was administered i.p. CV at 25 mg/kg followed (1 day later) by paclitaxel at 5 mg/kg. once a week. The drugs were administered intraperitoneally once a week for four consecutive weeks, and distortion product otoacoustic emissions (DPOAE) tests were performed at the beginning of the study before the first drug administration and at the end of the study after the last drug administration. All rats were sacrificed, and cochleae were removed for biochemical and histopathological analysis. Results: Biochemical data indicated that paclitaxel caused oxidative stress in the cochlea. Histopathological findings revealed the loss of outer hair cells in the organ of Corti (CO) and moderate degenerative changes in the stria vascularis (SV). It was observed that DPOAE measurements were significantly reduced at high frequencies. In groups which CV was administered together with paclitaxel, these biochemical, histopathological, and functional changes were favorably reversed. Conclusion: CV may have a protective effect against paclitaxel-induced ototoxicity when given.

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“…Each group contained eight randomly selected rats. The sample size of the study was determined according to similar studies previously conducted (5,15,16).…”

Section: Experimental Designmentioning

confidence: 99%

Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model

Atalay

Tatar

Dinçer

et al. 2021

Turk Arch Otorhinolaryngol

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“…The rats in the sham group received 1 ml of glycerol, one dose per day, for five days before ischemia. Rats in the whortleberry treatment group received 100 ml/kg of IP Vaccinium myrtillus, one dose per day, for five days before ischemia [16,19] . At the end of the experimental period, all rats were sacrificed by exsanguination from the carotid artery.…”

Section: Aortic Clamping Techniquementioning

confidence: 99%

“…Whortleberry (Vaccinium myrtillus L.) exhibits antioxidant and anti-inflammatory capacities due to its high anthocyanin, flavonoid, and phenolic acid content. It has also been reported to suppress enzymatic processes that cause oxidative damage by raising MDA and GSH levels and to effectively eliminate ROS [15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

Ergene¹,

Hemsinli²,

Karakişi³

et al. 2020

Braz J Cardiovasc Surg

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Objective: To examine the biochemical and histopathological renal effects of ischemia/reperfusion (I/R) injury using a ruptured abdominal aortic aneurysm (RAAA) model in rats and to investigate the potential protective effects of whortleberry (Vaccinium myrtillus). Methods: Thirty-two male Sprague-Dawley rats were randomly assigned into four groups-control, sham (I/R+glycerol), I/R, and I/ R+whortleberry. Midline laparotomy alone was performed in the control group. Atraumatic abdominal clamps were attached under anesthesia to the abdominal aorta beneath the level of the renal artery in the groups subjected to I/R. Sixty-minute reperfusion was established one hour after ischemia. The sham group received five intraperitoneal doses of glycerol five days before I/R. The I/ R+whortleberry group received a single intraperitoneal 50 mg/kg dose diluted with saline solution five days before I/R. All animals were finally euthanized by cervical dislocation following 60-min reperfusion. Results: Increases were observed in malondialdehyde (MDA) levels and tubular necrosis scores (TNS) in thin kidney tissues and in numbers of apoptotic renal tubule cells, together with a decrease in glutathione (GSH) levels, in sham and I/R groups. In contrast, we observed a decrease in MDA levels, TNS, and numbers of apoptotic renal tubule cells, and an increase in GSH levels with whortleberry treatment compared to the I/R group. Conclusion: Our findings suggest that whortleberry may be effective against acute kidney injury by reducing oxidative stress and apoptosis.

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“…[13] Vaccinium myrtillus L. (bilberry), commonly known whortleberry (WB), contains a number of phenolic compounds including flavonoids and tannins such as quercetin, myricetin and isorhamnetin, ellagitannins, phenolic acids, and anthocyanins. [14][15][16] The WB, an anthocyanoside and novel free radical scavenger, has been used as an antioxidant in vascular, cardiac, and intestinal tissues. [17] It has been shown to ameliorate oxidative stress in tissues reducing MDA levels, while increasing those of antioxidant enzymes.…”

mentioning

confidence: 99%

“…[17] It has been shown to ameliorate oxidative stress in tissues reducing MDA levels, while increasing those of antioxidant enzymes. [15][16][17][18] Recent studies have also identified no risk of interaction between WB and metabolism of therapeutic drugs. [14] In this experimental study, we aimed to investigate the potential protective effect of WB, the flavonoidand phenolic compound-rich antioxidant, against the deleterious effects on cardiac tissue of infrarenal aortic clamping-related I/R.…”

mentioning

confidence: 99%

The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats

Karakişi

Hemsinli

Ergene

et al. 2020

Turk Gogus Kalp Dama

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Bu çalışmada rüptüre abdominal aort anevrizmasının cerrahi onarımına bağlı iskemi reperfüzyon hasarının moleküler düzeyde kalp dokusu üzerindeki etkileri incelenerek, yaban mersininin muhtemel koruyucu etkisi araştırıldı. Ça lış ma pla nı:Mayıs 2018 -Şubat 2019 tarihleri arasında toplam 32 adet erkek Sprague-Dawley sıçan rastgele olarak kontrol, sham (iskemi-reperfüzyon+gliserol), iskemireperfüzyon ve iskemi-reperfüzyon+yaban mersini gruplarına ayrıldı. İskemi-reperfüzyon gruplarındaki sıçanlara bir saat süreyle hipovolemik şok uygulandı. Abdominal aort midline laparatomi ile eksplore edildi ve infrarenal seviyeden atravmatik mikrovasküler klempler uygulandı. Bir saatlik iskemi sonrasında, klempler kaldırıldı ve iki saat süreyle reperfüzyon uygulandı. Sham grubuna cerrahiden beş gün önce, günde bir kez intraperitoneal gliserol uygulandı. Yaban mersini grubuna, iskemi-repefüzyondan beş gün önce intraperitoneal yoldan yaban mersini tedavisi uygulandı. Bul gu lar:İskemi-reperfüzyon grubunda glutatyon düzeylerinde düşüş ve malondialdehit düzeylerinde artış gözlendi (sırasıyla, p<0.01 ve p<0.01). Kalp miyofibrillerinde kaspaz-3 pozitifliğinde de bir artış gözlendi (p<0.01). Yaban mersini tedavisi, yalnızca iskemi-reperfüzyon grubuna kıyasla, hem malondialdehit düzeylerini hem de kaspaz-3 pozitif kalp miyofibrillerinin sayısal yoğunluğunu azalttı ve kalp dokusundaki glutatyon düzeylerini artırdı (sırasıyla, p<0.01, p=0.011 ve p=0.011). So nuç:Rüptüre abdominal aort anevrizmalarının cerrahi onarımında iskemi-reperfüzyona bağlı kalp dokusu hasarının önlenmesinde yaban mersini yararlı olabilir.

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The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats

Abstract: The results obtained in this study show that whortleberry extract has a protective effect against cisplatin-induced ototoxicity.

Cited by 12 publications

References 22 publications

Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model

Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model

The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats

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