Rhinitis as an associated factor for anxiety and depression amongst adults

Bedolla-Barajas, Martín; Morales-Romero, Jaime; Pulido-Guillén, Norma Angélica; Robles-Figueroa, Martín; Plascencia-Domínguez, Brenda Renata

doi:10.1016/j.bjorl.2016.05.008

Cited by 28 publications

(34 citation statements)

References 24 publications

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“…Forty studies were further excluded after full-text reading, leaving 24 primary studies included in the systematic review . Among the included papers, 13 studies solely reported results on depression (19,(21)(22)(23)(28)(29)(30)(31)(32)36,37,39,41) , one study solely reported results on anxiety (35) and 10 studies presented results on both depression and anxiety (18,20,(24)(25)(26)(27)33,34,38,40) . Of these 24 primary studies, 12 studies (20,(26)(27)(28)(29)(30)(34)(35)(36)38,39,41) presented OR from multivariable regression models and were included in our main analyses -11 studies (20,(26)(27)(28)(29)(30)34,36,38,39,41) provided results from multivariable models assessing the association between A...…”

Section: Discussionmentioning

confidence: 99%

“…Table 1 summarizes the characteristics of the 23 included primary studies assessing the association between AR and depression (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(36)(37)(38)(39)(40)(41) . These studies were published between 1991 and 2019 and their sample sizes ranged from 88 to 240 million participants, resulting in a total of more than 243 million participants.…”

Section: Studies Characteristicsmentioning

confidence: 99%

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Anxiety and depression risk in patients with allergic rhinitis: a systematic review and meta-analysis

Rodrigues¹,

Franco-Pego²,

Sousa‐Pinto³

et al. 2021

Rhin

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Background: Allergic diseases appear to be associated with mood disorders. However, particularly regarding allergic rhinitis (AR), such association has not been adequately systematically reviewed. Therefore, we conducted a systematic review and meta-analysis to quantify the association between AR and depression and anxiety. Methodology: We performed an electronic search of PubMed, Web of Science and Scopus for observational studies assessing the association between AR and depression and anxiety. Such association was quantified by means of random-effects meta-analysis, with estimation of pooled odds ratio (OR). Sources of heterogeneity were explored by subgroup analysis. Results: We included a total of 24 primary studies, of which 23 assessed depression and 11 assessed anxiety. Of these, 12 studies presented OR from multivariable regression models and were included in our meta-analysis. AR was associated with higher odds of depression and anxiety. Conclusions: AR appears to be associated with high risk of depression and anxiety. While our results point to the importance of mental comorbidities among patients with AR, longitudinal studies are needed adopting uniform definitions and presenting results stratified by AR severity.

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Section: Discussionmentioning

confidence: 99%

Section: Studies Characteristicsmentioning

confidence: 99%

Anxiety and depression risk in patients with allergic rhinitis: a systematic review and meta-analysis

Rodrigues¹,

Franco-Pego²,

Sousa‐Pinto³

et al. 2021

Rhin

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“…[110] Circulating cytokines can also lead to increased glucocorticoid output and receptor dysfunction under stressful situations[111], which has been shown to be associated with MDD [112]. Some cytokines (i.e., IL-1β, IL-2, frequently elevated in AR patients [113] can induce expression of the CNS enzyme indoleamine 2,3-dioxygenase [114], which induces production of kynurenine from tryptophan. The kynurenine: tryptophan ratio in turn is linked to depression and suicidal behavior through neurotoxic, glutamatergic and possibly serotonergic dysregulation in the CNS [115••–117].…”

Section: Ar and Depressionmentioning

confidence: 99%

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Amritwar

Lowry

Brenner³

et al. 2017

Curr Treat Options Allergy

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Opinion Statement A high proportion of suicides visit their medical provider in the month prior to death, but depression, suicidal thoughts, and substance use are seldom addressed. For the clinicians routinely treating a substantial patient population with allergic diseases, there are additional concerns, as allergy has been linked with both depression and suicidal behavior. While psychotropic medications may affect diagnosis of allergies, medications used to treat allergies impact mood and behavior. Thus, we present an overview of the overlap of allergic rhinitis with depression and suicidal behavior in adults, based on clinical and epidemiological data, and our research and clinical experience. In summary, we suggest: 1) inquiring among patients with allergies about personal and family history of depression, substance use disorders, suicidal ideation and attempts 2) increased mindfulness regarding the potential effects of allergy medications on mood and behavior; and 3) for people identified with certain types of depression or increased suicide risk, a systematic multilevel collaborative approach. While for practical reasons the majority of patients with depression will continue to be treated by general or family practitioners, the allergy-treating provider should always consider integrated care for bipolar, psychotic or suicidal depression and incomplete remission, or relapsing and highly recurrent course. While awaiting results of much needed basic and clinical research to guide clinical approach for patients with comorbid allergic rhinitis and depression, the simple steps recommended here are expected to improved clinical outcomes in depression, including, on a large scale, reduced premature deaths by suicide.

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“…However, it can cause significant morbidity, through both the physical symptoms and its impact on quality of life and well-being [ 1 ]. It has a profound effect on many aspects of daily life such as sleep [ 2 ], work/school [ 3 ], and social life, having been shown to result in fatigue and mood changes [ 4 ], to impair cognitive function [ 5 ], and to lead to depression and anxiety [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The clinical burden of allergic rhinitis in five Middle Eastern countries: results of the SNAPSHOT program

Al-Digheari

Mahboub

Tarraf

et al. 2018

Allergy Asthma Clin Immunol

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BackgroundThe SNAPSHOT program provides current data on the allergic rhinitis burden in the adult general population of five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia and the United Arab Emirates, the latter three grouped into a Gulf cluster).MethodsA multi-country, cross-sectional, epidemiological program conducted by telephone in a random sample of the adult general population; quotas were defined per country demographics. Subjects were screened for allergic rhinitis using the Score For Allergic Rhinitis questionnaire. Current prevalence (last 12 months) was estimated. Disease severity and control were assessed using the Allergic Rhinitis and its Impact on Asthma classification and Rhinitis Control Assessment Test respectively. Quality of sleep, impact on daily activities and quality of life were measured using the Epworth Sleepiness Scale, Sheehan Disability Scale and EuroQol Five-Dimension questionnaire respectively. Multivariate logistic regression analyses were used to investigate risk factors and co-morbidities.Results1808 of 33,486 subjects enrolled in the SNAPSHOT program fulfilled the case definition for allergic rhinitis. Prevalence was 3.6% [95% CI 3.2–4.0%] in Egypt, 6.4% [95% CI 5.9–6.9%] in Turkey and 6.4% [95% CI 6.0–6.9%] in the Gulf cluster. Risk factors identified were country, co-morbid asthma and income. Subjects with allergic rhinitis reported a significantly lower quality of life compared to the general population (p < 0.0001). Overall, 55% of allergic rhinitis subjects were moderate/severe and 33% were uncontrolled. Both these groups reported impaired quality of life and quality of sleep and increased impairment of daily activities compared to mild/well-controlled subjects (p < 0.0001).ConclusionsAlthough the observed prevalence of allergic rhinitis in these Middle Eastern countries is low compared to western countries, its burden is considerable. Allergic rhinitis in general, and specifically uncontrolled and severe disease, results in a negative impact on quality of life, quality of sleep and daily activities.

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Rhinitis as an associated factor for anxiety and depression amongst adults

Abstract: AR and NAR are diseases associated to anxiety and depression, at least in women.

Cited by 28 publications

References 24 publications

Anxiety and depression risk in patients with allergic rhinitis: a systematic review and meta-analysis

Anxiety and depression risk in patients with allergic rhinitis: a systematic review and meta-analysis

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

The clinical burden of allergic rhinitis in five Middle Eastern countries: results of the SNAPSHOT program

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