Outcome of different facial nerve reconstruction techniques

Mohamed, Abdimajid; Omi, Eigo; Honda, Kazuo; Suzuki, Shinsuke; Ishikawa, Kazuo

doi:10.1016/j.bjorl.2015.12.010

Cited by 20 publications

(17 citation statements)

References 18 publications

(14 reference statements)

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“…Neurorestorative surgery may generally be divided into three categories: (i) neural reconstruction [35], such as bridging peripheral nerves between, above, and below the injury site, end-to-side facial-hypoglossal anastomosis [36]; (ii) neural decompression, such as cordotomy or myelotomy [25], and decompression for compression impairment of peripheral nerve fibers [37]; (iii) surgical revascularization [38]. Further evidence in support of functional recovery through neurorestorative surgery appeared this year [39,40].…”

Section: Neurorestorative Surgerymentioning

confidence: 99%

2017 Yearbook of Neurorestoratology

Huang¹,

Skaper

Mao³

et al. 2018

Journal of Neurorestoratology

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In 2016 we published the first Yearbook of Neurorestoratology, which summarized pathogenesis in nervous system disease and damage, as well as neurorestorative mechanisms and neurorestorative therapeutic results. Given the progress and achievements occurring in 2017, we have put together those major progresses as the “2017 Yearbook of Neurorestoratology”, which can help readers to easily follow the latest developments in Neurorestoratology.

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Section: Neurorestorative Surgerymentioning

confidence: 99%

2017 Yearbook of Neurorestoratology

Huang¹,

Skaper

Mao³

et al. 2018

Journal of Neurorestoratology

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“…Yang 49 reported that revascularization in sickle cell disease patients with Moyamoya syndrome could prevent stroke recurrence. Comparing various reanimation techniques such as facial nerve interpositional graft, hypoglossal-facial nerve transfer, and direct end-to-side facial-hypoglossal anastomosis, Mohamed et al 50 concluded that the latter technique through epineural suture is the most effective method with excellent outcomes for facial reanimation. Kochhar et al 51 reported that facial nerve direct end-to-end coadaptation to the hypoglossal nerve was effective in restoring facial tone and symmetry after facial paralysis.…”

Section: Neurorestorative Surgerymentioning

confidence: 99%

2016 yearbook of neurorestoratology

Huang¹,

Mao²,

Feng³

et al. 2017

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Neurorestoratology, a new interdisciplinary field, has gradually become a popular clinical discipline. Physicians and scientists in the neurorestoration field have discovered new pathogeneses of nervous system diseases and damage, explored new neurorestorative mechanisms, and obtained improving neurorestorative effects in clinical trials (or therapies). This paper summarizes the major progress achieved over the past year.

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“…However, the importance and usefulness of the remaining or few spontaneously regenerated FN fibers in regaining facial function when using HN-FN neurorrhaphy to treat facial paralysis remain controversial. Some authors considered that the injured FN could be completely sacrificed for HN-FN neurorrhaphy if facial paralysis needs to be surgically treated even if a few regenerated or remaining FN fibers existed, stressing that regenerated HN fibers alone could effectively induce facial reanimation (4,5). However, several other studies have mentioned the importance of the remaining or regenerated FN fibers (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Effects of the Remaining and/or Spontaneously Regenerated Facial Axons After Hypoglossal–Facial Nerve Neurorrhaphy for Facial Paralysis

Zhuang

Ling

et al. 2020

Front. Neurol.

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Background: The incidence of incomplete facial paralysis is now relatively higher in clinical practice, and surgical intervention is still desirable for patients with significant facial paralysis. However, the importance and usefulness of the remaining and/or spontaneously regenerated facial axons for regaining facial function when using hypoglossal-facial nerve (HN-FN) neurorrhaphy or other nerve-transferring methods to treat facial paralysis remain controversial. Objective: We designed a rat FN injury model with preservation of the anatomical structure followed by HN-FN side-to-side neurorrhaphy to investigate the effects of the remaining and/or spontaneously regenerated FN axons on restoration of facial function. Methods: After the evident return of facial function in 3 months following FN injury and HN-FN side-to-side neurorrhaphy, the FN was cross-sectioned again according to different ratios (0, 30, 70, and 100%) at the site rostral to the initial FN injury to retain, partially abolish, or completely abolish the spontaneously regenerated FN axons that had successfully reinnervated the paralyzed facial muscles. Then, FN function was assessed using clinical evaluation methods and electrophysiological examinations, as well as retrograde labeling and axonal counting assessments of the reconstructed nerve pathways. Results: The evaluations show that the remaining facial axons not only influenced the extent of regained function, such as facial symmetry, eye blinking activity, and vibrissae motion, but also had an impact on regeneration and innervation of hypoglossal motoneurons. Conclusion: Participation of remaining or spontaneously regenerated facial axons plays an important role in innervating paralyzed facial muscles by both facial and hypoglossal motoneurons, thus, reestablishing facial function.

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Outcome of different facial nerve reconstruction techniques

Cited by 20 publications

References 18 publications

2017 Yearbook of Neurorestoratology

2017 Yearbook of Neurorestoratology

2016 yearbook of neurorestoratology

Effects of the Remaining and/or Spontaneously Regenerated Facial Axons After Hypoglossal–Facial Nerve Neurorrhaphy for Facial Paralysis

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