Functional magnetic resonance and swallowing: critical literature review

Lima, Maíra Santilli de; Mangilli, Laura Davison; Sassi, Fernanda Chiarion; Andrade, Cláudia Regina Furquim de

doi:10.1016/j.bjorl.2015.08.006

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…not applicable. 45 . Neuroimaging studies show that the motor cortex and the basal ganglia as extrapyramidal motor network are involved in the central control of swallowing [46][47][48] .…”

Section: Discussionmentioning

confidence: 99%

Effects of cognitive and motor dual-tasks on oropharyngeal swallowing assessed with FEES in healthy individuals

Muhle

Claus

Labeit

et al. 2020

Sci Rep

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Dysphagia is frequent in many neurological diseases and gives rise to severe complications such as malnutrition, dehydration and aspiration pneumonia. Therefore, early detection and management of dysphagia is essential and can reduce mortality. This study investigated the effect of cognitive and motor dual-task interference on swallowing in healthy participants, as dual-task effects are reported for other motor tasks such as gait and speech. 27 participants (17 females; 29.2 ± 4.1 years) were included in this prospective study and examined using flexible endoscopic evaluation of swallowing (FEES). Using a previously established FEES-based score, the paradigms “baseline swallowing”, “cognitive dual-task” and “motor dual-task” were assessed. Scores of the three paradigms were compared using a repetitive measures ANOVA and post-hoc analysis. Mean baseline swallowing score in single task was 5 ± 3. It worsened to 6 ± 5 in the cognitive (p = 0.118), and to 8 ± 5 in the motor dual-task condition (p < 0.001). This change was driven by subclinical worsening of premature bolus spillage and pharyngeal residue. Oropharyngeal swallowing is not exclusively reflexive in nature but requires attention, which leads to motor dual-task interference. This has potential diagnostic and therapeutic implications, e.g. in the early screening for dysphagia or in avoiding dual-task situations while eating.

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“…not applicable. 45 . Neuroimaging studies show that the motor cortex and the basal ganglia as extrapyramidal motor network are involved in the central control of swallowing [46][47][48] .…”

Section: Discussionmentioning

confidence: 99%

Effects of cognitive and motor dual-tasks on oropharyngeal swallowing assessed with FEES in healthy individuals

Muhle

Claus

Labeit

et al. 2020

Sci Rep

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“…Swallowing is a coordinated physiological process, involving complex neuromuscular interactions (Ertekin and Aydogdu, 2003). Extensive research has shown that the swallowing network includes the brain regions of the primary sensorimotor system, supplementary motor area (SMA), insula, cingulate cortex, IFG, IPL, temporal lobe, precuneus, cerebellum, and brain stem (Hamdy et al, 1999a;Lang, 2009;Soros et al, 2009;Lima et al, 2015;Toogood et al, 2017). When any area of the swallowing network is damaged, dysphagia occurs (Domenech and Kelly, 1999;Gonzalez-Fernandez and Daniels, 2008).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Activation Patterns in Mirror Neurons and the Swallowing Network During Action Observation and Execution: A Task-Based fMRI Study

Jing

Lin

et al. 2020

Front. Neurosci.

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Background: Observation of a goal-directed motor action can excite the respective mirror neurons, and this is the theoretical basis for action observation (AO) as a novel tool for functional recovery during stroke rehabilitation. To explore the therapeutic potential of AO for dysphagia, we conducted a task-based functional magnetic resonance imaging (fMRI) study to identify the brain areas activated during observation and execution of swallowing in healthy participants. Methods: Twenty-nine healthy volunteers viewed the following stimuli during fMRI scanning: an action-video of swallowing (condition 1, defined as AO), a neutral image with a Chinese word for "watching" (condition 2), and a neutral image with a Chinese word for "swallowing" (condition 3). Action execution (AE) was defined as condition 3 minus condition 2. One-sample t-tests were performed to define the brain regions activated during AO and AE. Results: Many brain regions were activated during AO, including the middle temporal gyrus, inferior frontal gyrus, pre-and postcentral gyrus, supplementary motor area, hippocampus, brainstem, and pons. AE resulted in activation of motor areas as well as other brain areas, including the inferior parietal lobule, vermis, middle frontal gyrus, and middle temporal gyrus. Two brain areas, BA6 and BA21, were activated with both AO and AE. Conclusion: The left supplementary motor area (BA6) and left middle temporal gyrus (BA21), which contains mirror neurons, were activated in both AO and AE of swallowing. In this study, AO activated mirror neurons and the swallowing network in healthy participants, supporting its potential value in the treatment of dysphagia.

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“…The traditional rTMS stimulation site is roughly determined by locating the hot-spot area of a single swallowing muscle, e.g., the mylohyoid or pharyngeal muscle (Khedr et Numerous previous studies have shown that fMRI is a useful imaging technique for investigating changes in neuronal activity in the brain during swallowing, including motor, sensory and autonomic components (Lima et al, 2015). We believe that peak voxels activated by saliva swallowing in fMRI scans could be better stimulation sites than those identi ed by traditional route.…”

Section: Brain Areas Of Saliva Swallowing Task Fmri Activation In Exp...mentioning

confidence: 99%

“…Mylohyoid is only one of the representative muscles involved in the oral phase of swallowing. Swallowing is a complex sensory-motor process(Lima et al, 2015), one single muscle cannot represent the entire swallowing process. Functional brain imaging may be able to detect the neuronal patterns that govern this complicated sensory-motor process, elucidating the key neural mechanisms(Lima et al, 2015).…”

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confidence: 99%

Activation in the Swallowing Network by task-based fMRI: a seed-based Functional Connectivity Study

Chen,

Wang

et al. 2023

Preprint

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Background Task-based functional magnetic resonance imaging (fMRI) is an effective method for noninvasively studying brain activity. We aim to find representative brain areas of the swallowing movement and compare the functional connectivity differences in these areas. Methods A total of 23 participants were recruited to undergo task-based fMRI scans. Subject-level statistical analysis and group-level activation analysis were conducted using SPM12. Seed-based Functional Connectivity (FC) analyses were conducted to construct FC in brain level. We used the two-sample t-test to identify distinctive FC patterns in various seeds. The relationship between FC values and swallowing frequency was also explored. Results In experiment I, activation patterns were observed in swallowing-related brain regions in the 30-second saliva swallowing trial task, but not in 18s-on task at the group level. The peak voxels and coordinates of brain regions activated by saliva swallowing in experiment II were used as the seeds in resting-state fMRI FC analysis. Two sample t-tests showed that the seed located in right pericentral area (Seed3) had significantly more intensive FC than the seed located in cingulum (Seed5) in left postcentral gyrus, the seed located in left pericentral area(Seed4) had significantly more intensive FC than the seeds located in cerebellum(Seed1,Seed2) or in cingulum(Seed5) in right postcentral gyrus, Seed5 had significantly more intensive FC than Seed1,Seed2,Seed4 in right middle frontal gyrus, right superior frontal gyrus and left supplementary motor area separately. No significant positive or negative correlations between swallowing frequency and FC values were found based on Seed 3,4,5. Conclusions Saliva swallowing trail task with self-paced rhythm in sufficient time can activate the swallowing-related brain regions effectively. The activation peaks in the bilateral pericentral area are representative in the swallowing process and could be new therapeutic targets for poststroke dysphagia instead of traditional route. Trial registration number (TRN) ChiCTR2100054835; Date of registration: 28 December 2021. https://www.chictr.org.cn/

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Functional magnetic resonance and swallowing: critical literature review

Cited by 5 publications

References 29 publications

Effects of cognitive and motor dual-tasks on oropharyngeal swallowing assessed with FEES in healthy individuals

Effects of cognitive and motor dual-tasks on oropharyngeal swallowing assessed with FEES in healthy individuals

Comparison of Activation Patterns in Mirror Neurons and the Swallowing Network During Action Observation and Execution: A Task-Based fMRI Study

Activation in the Swallowing Network by task-based fMRI: a seed-based Functional Connectivity Study

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